12^th Annual Pharma Middle East Congress Sep 25-26, 2017 Dubai, UAE

Biography:

Dr. Sawsan Abuhamdah is a Jordanian registered Pharmacist, has completed her PhD from Durham University, UK and postdoctoral studies from Granada Medical School, Department of Pharmacology, Spain and has won postdoctoral Fulbright Research Award at the University of Toledo, Department of pharmacology and experimental therapeutics, Ohio, USA, 2014-2015. Promoted to associate professor in 2014 at the faculty of pharmacy, University of Jordan and now acting as deputy dean, College of Pharmacy, Al Ain University of Science and technology, Abu Dhabi, UAE. Dr. Abuhamdah has published many original research articles in peer-reviewed journals and participated in the preparation of many symposium abstracts. Dr. Abuhamdah is a member of the British Pharmacological Society (BPS), British Neuroscience Association (BNA), Sigma Phi Sigma Pharmaceutical Sciences Honor Society, University of Toledo, USA, Jordan Pharmaceutical Association and has been serving as an editorial board member of reputable pharmaceutical journals.

Abstract:

Agitation is a common clinical challenge; it often precedes the diagnosis of common age-related disorders of cognition such as Alzheimer's disease. More than 80 percentages of people who develop Alzheimer's eventually become agitated or aggressive. Agitation also accompanies dementia, it has been estimated that agitated behaviour occurs in 70-90 percentage of the patients with dementia at some point during their illness. An ideal agent for the acute treatment of agitated patients should be easy to administer and not traumatic; provide tranquilization without excessive sedation; have a rapid onset of action and have low risk for significant adverse reactions and drug interactions. Currently available pharmacologic treatments for agitation do not fulfil all of these criteria; there are significant unmet needs for novel anti-agitation treatments. Several plant species are used for their effect on symptoms such as anxiety, restlessness, and excitability these include Melissa officinalis, commonly known as lemon balm a member of the mint family, has been considered for many centuries as a "calming" herb. It was used as far back as the middle ages to reduce stress and anxiety and promote sleep. In order to elucidate the pharmacological basis for Melissa actions, a pharmacological screen has been conducted using radioligand binding focusing on a range of ligand-gated ion channels, in rat cortical membranes. Melissa oils were sourced from four separate authenticated suppliers. Interactions of the oils with both G-protein coupled receptors (5-HT1A, 5-HT2A, muscarinic M1 and histamine H3) and ligand-gated ion channel receptors (NMDA, nicotinic and GABAA channel, agonist and benzodiazepine sites) implicated in agitation in severe dementia have been examined.

Biography:

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Biography:

Saeed Albaraki completed his PhD from University of Leeds, UK in 2011 in industrial pharmacy and pharmaceutical engineering.  Dr. Albaraki is the Deputy Director of the Scientific Research Centre of the Medical Services of the Armed Forces, KSA. He has published his research work on pharmaceutical formulation, manufacturing, plasma fractionation and pharmaceutical engineering in reputed journals and has also presented his work in national and international scientific conferences and meetings.

Abstract:

Technically, human plasma for fractionation may be obtained by separation of plasma from whole blood (recovered plasma) or by apheresis (source plasma). The use of Apheresis technique is very helpful in the recovery of plasma and yields almost four times more than other techniques. The bulk of the plasma collected for fractionation is provided by paid donors. For example, USA plasma derived yield from whole blood amounted to 3.5 million litres, while 12 million litres was obtained via plasmapheresis. As with other pharmaceutical industries, PDM fractionation investment is based on four aspects, Knowhow, market, high capital and raw material (Plasma). The main obstacle to start local plasma fractionation is the maintenance of a regular, adequate and safe source of supply of around 300K litres of   plasma. In case of shortage of plasma supplies, the alternative project such as self-sufficiency program (SSP) need to be implemented. Finland, Malaysia, Norway and Singapore are good example of self-sufficiency fractionation toll of local plasma. SSP based on local collection of plasma (around 30k-50k litres ) and shifting fractionation through special contracts with international fractionators. Consumption of PDM products such coagulation factors FVIII and FIX, albumin and immunoglobulins (IVIG) shows around 10% annual increment. The recent applications of IVIG in  Alzheimer’s disease  and some other  neurological disorders has created a profound interest and use of PDM products. Unlike pharmaceutical industry, around 40% of the final price for the manufacturing of PDM  goes to raw materials and not to marketing. Collection of local plasma for fractionation will dramatically reduce the final prices of the products. In addition, building up a national  collection program of plasma will increase the local strategic stock for any crisis. The fractionated yield of coagulation factors produced by Self-sufficiency fractionation program is very high and will greatly  help to start a prophylaxis program for haemophilic patients. Local fractionation or SSP will also help in the creation of the much needed  local employment opportunities and support the local economy. SSP will also  help to secure a reglar , uninterrupted  and safe supply for the patients receiving PDM . A better quality control can also be implemented to strenghten the safety standards of the final products and the influence of any possible gene therapy will be excluded.

Biography:

Tuba Aydin is currently working as an assistant professor in the Faculty of Pharmacy at the Agri Ibrahim Cecen University, Turkey where she has been a faculty member since 2013. She completed her PhD at Ataturk University, Turkey. She has expertise in isolation and characterization of phytochemicals from natural products.

Abstract:

Sepsis has a development that can result in death, through the passage into the blood of microorganisms entering the body and spreading to all organ systems. Artemisia dracunculus L., tarragon, which is used in various parts of the world as spice, has long been used in traditional therapy. Tarragon leaves have important coumarin content and contain high amounts of herniarin (HRN).

One of the most frequently used animal models in the study of sepsis is cecal ligation-puncture in rats’. In the present study, effects of HRN, isolated from tarragon, was investigated on sepsis induced rats’ liver tissues. Therefore, 40 male rats were divided into 4 groups as Sham, Control, HRN-150 and HRN-300. HRN was orally given (at doses of 150 and 300 mg/kg), and then rats’ cecums were ligatured and perforated by a cannule. After 24 hours after administration of HRN, rats were euthanized under high dose anesthesia. Both histopathologic and biochemical examinations were performed in the liver tissues of sepsis induced rats.  Lipid peroxidation (LPO) and glutathione (GSH) levels, as well as superoxide dismutase (SOD) and catalase (CAT) activities were measured as biochemical parameters.

In the control group, as compared with sham group, both LPO level and CAT activity increased significantly (p <0.05), in contrast to the decreased amouts of GSH and SOD activity.  In the HRN groups, the LPO and CAT was significantly decreased, and also decreased amouts of GSH and SOD activity was increased dose dependently. According to the results histopathologically, damage findings are decreased as parallel to the biochemical data in a dose-dependent manner. As conclusion HRN dose-dependently decreased sepsis resultant liver damage (p <0.05).

Biography:

Mona Alqahtani is a student in College of Pharmacy- King Saud University, Saudi Arabia.

Abstract:

Biography:

Collins Ovenseri Airemwen bagged a Doctor of Pharmacy (PharmD) degree from the University of Benin, Benin-City, Nigeria and a Master of Philosophy degree in Pharmaceutics and Pharmaceutical Technology with a distinction from the same University in 2016. He is currently pursuing his PhD. He has published more than 8 papers. His research is on controlled drug delivery.

Abstract:

This study was carried out to formulate and evaluate gastro-retentive floating matrix tablets (GRFMTs) of Metformin using Grewia mollis gum.

Grewia polysaccharide gum was obtained from the inner stem bark of the edible plant Grewia mollis, Juss, (Fam. Tiliaceae). Granules were prepared by wet granulation technique using the extracted natural gums at varying concentrations (2, 4, 6 and 8% w/w). Sodium bicarbonate (30%) and tartaric acid (5%) were incorporated as the gas generating agents. All granules were evaluated for micromeritic properties. Granules were compressed at an optimized compression pressure of 35 arbitrary unit on the load scale using a single punch tableting machine. Tablets were evaluated for hardness, friability, floating lag time, in vitro buoyancy test and drug release profiles. Compatibility test of the excipients with the API (metformin) was also done using FTIR.

Results revealed that all formulated GRFM granules were free flowing with angle of repose and Carr’s index ≤ 31^º and ≤ 14% respectively. The floating lag time for GRFM tablets formulated with Grewia mollis was ≤ 850 s. The in vitro buoyancy test of GRFM tablets formulations using the natural gum alone (i.e. without the incorporation of Eudragit^® RL₁₀₀) were <12 h while those formulations with the incorporation of Eudragit^® RL₁₀₀ were >12 h. There was a significant difference in tablet hardness with increase in binder concentration (p<0.05). The % maximum release (m_∞) and time to attain this (t_∞) for all GRFMTs were ≥87% and ≥4 h respectively. All the formulations fitted well into Higuchi model release kinetics. Release exponent (n) for all the formulations have their exponent values > 0.45, hence their release mechanism was by Non-Fickian diffusion.

GRFM tablets of metformin have been developed for the first time using Grewia mollis gum which can sustain drug formulation for up to 10 h and improve the bioavailability of drugs with narrow absorption window in the upper part of the GIT. Batch GM5 showed a better sustained release profile which can be taken as the optimized formulation.

Biography:

TBA

Abstract:

A specific stability indicating high-performance thin-layer chromatographic method for analysis of Tolterodine Tartrate both as a bulk drug and in formulations was developed and validated. The method employed HPTLC aluminum plates precoated with silica gel GF254 (aluminium sheet) as the stationary phase. The optimized mobile phase system consisted of Ethyl acetate: Methanol: TEA (5:5:0.2 v/v/v) which gave compact spots for Tolterodine Tartrate at 𝑅𝑓 of 0.65. Tolterodine Tartrate was subjected to forced degradation studies in order to check the specificity of the method. Analysis of the drug was carried out at 280 nm. The calibration plots showed linear relationship in the concentration range of 800 – 1200 ng per band. Moreover, linearity was also confirmed by verification of homoscedasticity of variance. According to validation studies, the developed method was repeatable and specific as revealed by % RSD less than 2 and hence can be used for routine analysis of pharmaceutical formulation. The % recovery was found to be 99.23% to 101.00%. Stress studies were conducted on the drug substance and product under the ICH prescribed stress condition viz. hydrolysis, oxidation, photolysis and thermal stress. The drugs showed sufficient decomposition under acidic and alkaline hydrolysis and oxidation. The forced degradation study data represented that the degradation pattern for Tolterodine Tartrate was in Sunlight > UV light > Acid > H₂O₂ > Base. The developed Stability indicating HPTLC method was found to be sensitive, precise, accurate, economical and reproducible for analysis of pharmaceutical formulation containing Tolterodine Tartrate. Statistical analysis proves that this method can be successfully employed for quantitative analysis of Tolterodine Tartrate in pharmaceutical dosage form.

Biography:

TBA

Abstract:

Introduction:

Antimicrobial resistance(particularly antibiotic resistance) is spreading now, and there are few prospects for the development of new classes of antibiotics in the short term. However, there is today considerable awareness of the need for and political support for action to combat antimicrobial resistance. Antimicrobials are being used and misused by patients and healthcare providers. Monitoring antimicrobial prescription and consumption behavior provides insights and tools needed to inform therapy decisions, to assess the public health consequences of antimicrobial misuse and to evaluate the impact resistance containment interventions. All reports from WHO tell us about post antibiotics era that will be start if we don’t work quickly on antibiotics resistance by all efforts and due to situations of my country in Libya now need a lot of studies to decrease corruption in budgets put for health sector.

Experimental methods:

Study made by pilot method and we depend on data collected from dispensing papers of medical supply ward in Al Wahda hospital. 

*medical statistics office of Al Wahda hospital

*Al Wahda hospital laboratory

*data collected for 3months and on 477 in- patients of wahda hospital.

Results and discussion:

After collecting data from dispensing paper that is based on treatment chart, we covered 477 patients for 3months by 2169 ceftri-702 gent-1360 aug-547 cefot-23amik. And we noticed that the percentage of higher antibiotics use was ceftriaxone equal to 45.18 % of totality and use of broad antibiotics rather than narrow  antibiotics by 84.9% and all principles of clinical pharmacology direct to use narrow firstly plus first line antibiotics  therapy as shown in figure 1,2 respectively. And the percentage of patients those received antibiotics that is available in hospital from all patients  was 25.3% . we found that the most higher antibiotic sensitive to bacteria was CIPRO and others appear as shown in table below where Ceftriaxone in lower rank by 2.3% as shown in figure no:3 and we found percentage of cultures done to inpatient was 28.09% to all patients' take antibiotics and others take its blindly and we noticed that the higher bacteria strain diagnosed was staph .c. aur and we found that 70 culture tests from 134 shown no bacterial growth which shows mistake in medical  requests. As shown in fig:no 4, we found the higher ward using antibiotics from all wards is FMW and this ward less one  request to culture by 2 requests along study time.

Figure 1

Figure 2

Figure 4

Conclusion:

1- Dispensing antibiotics depending on treatment chart decrease wasting in hospital budget.

2- Decision of antibiotics use not comply enough with cultures results of our lab.

3- Staph and Kleb, E.coli much more present in(gyne –pediatric) wards in our hospital.

4- No antibiotic should be used recklessly. However difficult it appears to be to select for resistance in vitro. On the other hand, the attitude that 'All new antibiotics should be locked away' risks stifling innovation whilst denying life-saving treatment debate on their use of new anti-gram-positive agents are sure to intensify  and it is vital that they take place on a basis of science not knee-jerk restrictions or over-zealous marketing .

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Biography:

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Biography:

Dr. Krishna Murti has completed  PhD in Pharmaceutical Sciences and has more than 15 years of Experience in academic as well as industry both national and international.His area of interest is diabetes ,cancer and wound healing .Presently ,He is working as Faculty in Department of Pharmacy Practice in NIPER ,Hajipur, institute of National Importance ,established by Government of India. He has published more than 80 papers in reputed journals and has been serving as an editorial board member of reputed journals. He is member of several Pharmaceutical bodies. 

Abstract:

Objectives: Comparative effect of fixed dose combination of Telmisartan+Amlodipine versus Telmisartan and Amlodipine alone on Brain Natriuretic Peptide (BNP), Cystatin - C and blood pressure in essential hypertensive patients.

Methods: A total of 90 patients, fulfilling inclusion and exclusion criteria were enrolled in the study after obtaining informed consent. Patients were randomized into three treatment groups i.e. Telmisartan 40 mg (Group A), Amlodipine 5 mg (Group B)  and low fixed dose combination of Telmisartan 40 mg +Amlodipine 5 mg (Group C) once daily for three  months. The systolic BP, Diastolic BP, BNP, Cystatin C were recorded at the start of the study and end of the study.              

Results: In the present study, significant reduction of mean systolic blood pressure (SBP) and mean diastolic blood pressure (DBP), BNP & Cystatin - C was seen in low fixed dose combination of Amlodipine 5 mg and Telmisartan 40 mg (Group C) compared to Telmisartan 40 mg and Amlodipine 5 mg mono-therapy. Some of adverse drug reactions (ADRs) were reported in Amlodipine mono-therapy group, like ankle oedema, headache, constipation and fatigue.

Discussion and Conclusion: Low fixed dose combination therapy appears to be a better therapeutic approach in relation of BP, BNP and Cystatin-C control than mono-therapy for primary hypertensive patients.

Biography:

Prof. M Al-Arifi. Has graduated with Bsc in pharmacy from College of Pharmacy, King Saud University, 1986, and finished his PhD, in clinical pharmacy, from School of pharmacy, Queens' University of Belfast, 1993, since then and up till now in the clinical pharmacy department, college of pharmacy King Saud University. Has engaged in teaching and supervising graduate and undergraduate students and published more than fifty articles for the last twenty years.

Abstract:

The study was conducted during the period from May 2006 to September 2006 in Riyadh city. The survey composed of the demographic characteristics of the respondents, asked 6 Likert type questions about the attitudes of the pharmacists toward mental illness,   providing pharmaceutical care to mentally ill patients, the barriers of the provision the service and differentiated between different types of mental illness and compares them with cardiovascular medications.  Although pharmacists have generally positive attitudes toward both mental illness and providing pharmaceutical care to mentally ill patients, they felt uncomfortable counseling or follow-up monitoring patients for adverse drug-related problems when consider distinguishing between different types of mental illness.

Biography:

Matt is a Programme Lead at NHS Health Education England. Matt leads an innovative workforce transformation programme, with a remit to understand and address Emergency and Urgent Care clinical workforce challenges in the UK. Since taking up his current role in April 2013, Matt has developed and led a portfolio of award winning test-of-concept and pilot projects at local, national and international levels. Successes to date include: the development of a national GP Fellowship in Urgent and Acute Care; producing an award-winning, world-first, pharmacist clinician programme; delivering a portfolio of Emergency Medicine Skills training for Staff Grade and Associate Specialists; supporting development of the Physician Associate profession in the UK; developing training and healthcare pathways for the veteran workforce and armed forces community (respectively). Matt and his team deliver programmes with an evidenced ability to enhance workforce capability and improve standards of patient care. 

Abstract:

In the future urgent, acute and emergency medicine clinical workforce, new models of care and care delivery need to be developed, in order to maintain and enhance standards of safe and accessible patient care. A departure from traditional (doctor-led) approaches to workforce planning and an understanding of the scope and governance surrounding emerging clinical roles is necessary to develop a sustainable, multi-skilled workforce across primary, community and secondary care. Today’s healthcare workforce includes an ever-increasing number of non-doctor professionals, undertaking clinical work in the medical domain. The traditional, medicines-focused role of the pharmacist is being challenged by NHS Health Education England (HEE) - the organisation responsible for NHS workforce training and development in England - and its national stakeholders.

It is contended that the future pharmacist clinician should be able to confidently and competently manage patients at an advanced clinical level – with health assessment, diagnostics and clinical examination skills comparable with that of a mid-level clinician. A recent three-year programme undertaken by HEE, evaluated the potential for pharmacists to manage patients in the emergency department and across urgent and acute care in England. Evidence from the ‘Pharmacists in Emergency Departments’ (PIED) suite of studies suggests that pharmacists with advanced training may clinically manage up to 36% of patients attending emergency departments. The HEE programme examines this data and proposes enhanced clinical development pathways for pharmacists. The programme team propose a change in thinking around the deployment of pharmacists in the future integrated clinical workforce across urgent, acute and emergency care.

Biography:

Fadhila Helnisa has completed her bachelor degree from Faculty of Pharmacy on 2014, Andalas University (Indonesia) and has successfully fulfilled all the academic requirements of Indonesian Pharmacist Profession on 2015. Now, she is studying at Master of Toxicology, University of Birmingham.

Abstract:

A study on clinical pharmacokinetics aspect of drugs in patients with hypertension at the Internal Medicine Department of Hospital Padang Panjang (Indonesia) has been conducted. The aims of the research was to determine the accuracy of antihypertensive medications to achieve targeted blood pressure and to assess the dosage regimen based on liver and/or kidney functions, also drug interactions. The study was performed from December 2013 to February 2014. This is observational prospective study with 49 patients who met the inclusion and exclusion criteria. Data was analyzed descriptively. Results showed that 60.42% antihypertensive medications were effective but 39.58% not effective to reach the targeted blood pressure. There were 3 cases in appropriate dose regimen covering 1 case digoxin, 1 case furosemid and 1 case captopril. From the cases, doses exceed individual dose included digoxin and captopril.  There were 14 cases of pharmacokinetic interactions and 2 cases of pharmacodynamic interactions. Interaction between amlodipine and diltiazem (7 patients, 14.58%) influenced the blood pressure control in patient. These are pharmacokinetic interaction because diltiazem decreases metabolism of amlodipine by inhibiting enzyme CYP 3A3/4.

Biography:

Abstract:

Background: Medication-related hospital admissions in Australia have previously been estimated to account for approximately 3% of all hospital admissions, with hospital entry points being a point of vulnerability. The timely medication review and reconciliation by a pharmacist at the early stage of an admission for patients admitted to the Acute Medical Unit (AMU) would be beneficial. Setting: The Emergency Department (ED) and AMU in a 300 bed tertiary teaching hospital, in South Australia. Objective: To investigate the impact of a Medical Admissions (MA) pharmacist on the proportion of AMU patients who receive a complete and accurate medication history by a pharmacist prior to admission and within 4 h of presentation. Method: This prospective observational study with a non-concurrent parallel study design examined a standard clinical pharmacist service within the AMU and ED to a Medical Admissions (MA) Pharmacist, in addition to the standard AMU and ED pharmacist service. Continuous variables were analysed using a two sample t test, whilst categorical data were analysed using Fisher’s exact test. Risk ratios were also calculated for categorical data, with p < 0.05 taken as statistically significant. Main outcome measures: Rates of completion of a complete medication history prior to admission and proportion of patients seen within 4 h of presentation by a pharmacist. Results: The intervention resulted in more patients receiving a complete medication history prior to admission (2.7% in the control group vs 18.5%, p < 0.01) and being seen by the pharmacist within 4 h of presentation (1.6% in the control group vs 7.5%, p < 0.01). Conclusion: Implementation of an extended hours clinical pharmacy service in the form of a medical admissions pharmacist based in the ED significantly increased the number of complete medication histories and clinical reviews completed for patients being admitted to an AMU. These were also completed earlier in the patients’ admission. There was also a small trend toward increasing the proportion of patients discharged by 11 am in the intervention group.

Biography:

Alamelu AL, a 20 year old research enthusiast is doing her 3^rd year M.B.B.S in Govt. Kilpauk medical college and hospital. Being a budding researcher, she loves to gain knowledge in the field of research by exploring various conferences. She has published a paper in an indexed journal and waiting to contribute to the field of research in future.

Abstract:

BACKGROUND: Stroke is one of the most devastating neurological conditions. Diabetes mellitus is a well-established independent risk factor for stroke. Metformin in addition to its anti-hyperglycaemic effects provides additional cardioprotective effects due to its action on lipid metabolism, endothelial function and platelet activity. Better cerebrovascular outcomes are seen with Metformin due to the fact that it reduces the risk of thrombosis through its effect on fibrinolysis by lowering PAI-1 concentration along with Metformin induced increase in insulin sensitivity. Thus Metformin could be developed into a disease modifying drug to treat stroke. But the association between the duration of Metformin therapy and the severity of stroke has not yet been assessed so far. This study aims at assessing the impact of Metformin and its duration of use on the severity of ischemic stroke in patients with type 2 DM.

OBJECTIVES: To measure the severity of stroke using NIHSS and mRS score and to correlate the severity of stroke with the duration of  Metformin therapy.

METHODS: This is a comparative cross sectional study comprising 60 stroke patients with type 2 DM, without severe renal impairment (serum creatinine < 1.7 mg/dl). Severity of stroke was assessed using National Institute of Health Stroke Scale(NIHSS) and modified Rankin Scale(mRS). The correlation between the stroke severity and metformin use was expressed as correlation coefficient. T-test was used for testing significance between proportions. p < 0.05 was considered as statistically significant.

RESULTS: The mRS score was statistically significant indicating that metformin therapy was associated with decreased severity of stroke showing improvements in functional outcomes (p = 0.017, CI – 95%). However the NIHSS score was not statistically significant (p = 0.114, CI – 95%) and no significant correlation was found between the duration of metformin use and severity of stroke.

CONCLUSION: Metformin therapy in patients with type 2 diabetes mellitus improves functional outcomes of stroke. However in this study, the correlation between the duration of metformin use and the severity of stroke was statistically not significant. The smaller sample size could have limited the statistical interpretation of data. A proper documentation and recording of treatment history of the patients with a larger population size could increase the statistical significance of the study. 

Biography:

Mr. Kaselekela Ponshano completed his advanced diploma in Pharmacy at the age of 27 years from Evelyn Hone College, Zambia and advanced studies in the rational management of medicines from Swiss Tropical Institute, Switzerland. He is the coordinator for pharmacovigilance in the northern region of Zambia. He has published more than 2 papers in reputed journals and has served as the secretary for the Copperbelt University Senior Administrative Staff association (CUSASA). He is the current senior Pharmacy technologist at the Copperbelt University.

Abstract:

Hypertension is described as the persistent increase in blood pressure (BP) above 120/80mmg. With the introduction of newer medicines such as TELMA-H (Telmisartan + hydrochlorothiazide) as well as Amlodipine, many patients used to take other antihypertensive drugs for the management of hypertension which proved to be not bearing positive results to some patients. TELMA-H plus Amlodipine drug was suggested to be introduced to some of the hypertensive patients whose responses to other antihypertensive were not good. A study was done to assess its effectiveness at the Copperbelt University health facility.

A total of 35 male and female clients with unstable BP as well as those not responding well on other antihypertensive drugs were enrolled on the study. The patient’s drug regiments were changed upon their review dates. A register was then opened for all the clients enrolled. The information captured on the register included names of Clients, their current BP, their previous drug regiments and the dates the therapy changed. The treatment were administered once daily for 2 months. A follow- up was made to all patients weekly starting from 1 to 8. Every week there BP were monitored and measured.

Reduced BP was observed to the desired levels. The systolic and diastolic blood pressure reduction were identified in all the clients than to those whom we did not change the therapy. The reduction in BP improved the quality life. treatment of hypertension using TELMA-H plus Amlodipine was proved to be effective in the management of hypertension.

Biography:

He has completed M.Phil. From Quaid I Azam University, Islamabad and has published more than 6 research papers.

Abstract:

Objective: To describe and analyze the prevalent prescribing trends of anti-asthmatics drugs among 1-12 year old children in Lahore, a major city of Pakistan, is the objective of this study. In addition, the study attempts to determine the most prevalent type of asthma amongst the stated age group of subjects. Method: Drug utilization data was recorded from 100 prescriptions collected from Children Hospital, Model Town, Lahore, during the study period of December 2014 to December 2015. The study subjects were randomly selected with 18% falling in the age group of 0-4, 48% from the age group 4-8 and 34% falling in the age range of 8-12. There were 44% of female subjects and 56% of males. Combination therapy utilization was found in 99 patients while mono-therapy was employed in 1 subject. Results: The study results reveal that the most common form of asthma prevalent in the study sample is intermittent asthma. The majority of the patients receiving therapeutic regimens have at least 3 drugs per prescription. An interesting aspect highlighted by the study is the practice of using trade names in prescribing drugs and its implications. Albuterol was prescribed in 34.90% of the subjects, followed Montelukast at 29.41%, Flixitide occupied the third rank
at 12.16% followed by Salmetrol + Fluticasone combination at 7.84%, Clenil and loratidine occupied 5.49%, Prednisolone 3.14% and lastly Cetirizine at 1.18%. Conclusion: Polypharmacy was practiced in all patients with the exception of one. We also found that therapeutic regimens were irrationally prescribed to children which could cause damage to their vital organs. Thus, intensifying the need of proper strategy development to ensure appropriate and efficient use of resources. Furthermore, continuing educational programs for the physicians and patients on rational drug prescribing and utilization are
needed to pave way for positive patient outcomes.

Biography:

Rahul Kumar is presently pursuing PhD in Pharmacy Practice in National Institute of Pharmaceutical Education & Research, Hajipur, an institute of national importance established by Government of India. He has comleted his Masters from NIPER, Hajipur and B.Pharm from Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal (both being premiere institutes of India). He has qualified national level exams for scholarships from AICTE and NIPER during masters as well as during  PhD. His research interest includes Clinical Pharmacy in Oncology, Public Health and Environmental Health.

Abstract:

Cervical cancer is the second most common gynecological malignancy worldwide. According to HPV Information Centre, Spain (Aug’ 2014), in India approximately 1,22,844 women are diagnosed with the disease every year and of them 67,477 die due to the disease. The etiology is multifactorial. Malondialdehyde (MDA) is important peroxide which is a measurement of oxidative stress and can be a predictive in the early detection of cervix cancer. This study has been undertaken to investigate the association of Arsenic and malondialdehyde (MDA) level with haematological changes at the first clinical presentation. Thiobarbituric Acid Reactive Substances (TBARS) assay was performed on the blood serum samples taken from the freshly diagnosed cervical cancer patients. For haematological changes, haematocytometer and Sahli’s method was followed. Mean MDA level in the serum of freshly diagnosed cervix cancer patients was found to be elevated than the healthy volunteers. Mean RBC count was found to be comparatively less than the normal and mean WBC was found to be comparatively higher than the normal. MDA may have a predictive role in treatment response. MDA levels are higher in patients of cervical cancer and suffer from haematological derangements. Arsenic is also one of the agents for causing Oxidative Stress. Arsenic is considered responsible for generation of free radicals and eventually for apoptosis. Arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count and Heamoglobin levels were performed according to standard protocol. MDA was in direct proportion with arsenic concentration and inversely proportional to RBC and Haemoglobin in CaCx  patients. Arsenic is one of the major causative agents for oxidative stress and hence may be a risk factor leading to cancer including CaCx.

Biography:

Idin Alikhani, 3^rd year pharmacy student of  Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract:

Introduction and Background: The impacts of self-medication on the health care costs and patients safety are very significant. Therefore, realizing drugs that is being requested more frequent by people from pharmacies can help finding a reasonable and rational solution to this problem. All around the world, it is evaluated that half of all medicines are prescribed, dispensed or sold inappropriately, and half of all patients do not take their drugs properly. Inappropriate use of drugs is costly and extremely detrimental for both individual and society.

Methods: In this descriptive cross-sectional study, 100 pharmacies (More than 80% of established pharmacies in Kermanshah) filled a 10-item researcher made questionnaire. Data were analyzed using analytic statistical programs.

Results: Results showed that the following drugs had most frequency in patients’ requests: Cap Amoxicillin 500 mg (85.7%), Cap Gelofen® 400 mg (84.4%), Tab Acetaminophen codeine (76.6%), Tab Adult cold (75.3%), Tab Ranitidine (67.5%), Amp Dexamethasone (61.0%), Syr Diphenhydramine compound (53.2%), Vial penicillin 6.3.3 (44.1%), Tab Alprazolam 1 mg (36.3%), cap Novafen® (26.5%)

Discussion and Conclusion: The most important reason of self-medication could be due to 1- Self-awareness assumption about medical and pharmaceutical issues 2- Consumption of mentioned drugs in non-serious illnesses such as common cold, headache, gastrointestinal diseases and sleep disorders 3- Frequent suffering disorders which lead to take medicine, 4- Physician’s crowded office 5- High cost of medical care services, low income and social poverty.

Biography:

Abstract:

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this study. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conduct.

Biography:

Saeed Albaraki completed his PhD from University of Leeds, UK in 2011 in industrial pharmacy and pharmaceutical engineering. Dr. Albaraki is the Deputy Director of the Scientific Research Centre of the Medical Services of the Armed Forces, KSA. He has published his research work on pharmaceutical formulation, manufacturing, plasma fractionation and pharmaceutical engineering in reputed journals and has also presented his work in national and international scientific conferences and meetings.

Abstract:

Technically, human plasma for fractionation may be obtained by separation of plasma from whole blood (recovered plasma) or by apheresis (source plasma). The use of Apheresis technique is very helpful in  the recovery of plasma  and yields almost four times more than other techniques. The bulk of the plasma collected for fractionation is provided by paid donors. For example, USA plasma derived yield from whole blood amounted to 3.5 million litres, while 12 million litres was obtained via plasmapheresis. As with other pharmaceutical industries, PDM fractionation investment is based on four aspects, Knowhow, market, high capital and raw material (Plasma). The main obstacle to start local plasma fractionation is the  maintenance of  a regular, adequate  and  safe source of supply of around 300K litres of   plasma. In case of shortage of  plasma supplies,  the alternative project such as self-sufficiency program (SSP) need to be implemented. Finland, Malaysia, Norway and Singapore are good example of self-sufficiency fractionation toll of local plasma. SSP based on local collection of plasma (around 30k-50k litres ) and shifting fractionation through special contracts with international fractionators.

Biography:

He is working as a professor at the Amapá Federal University, Amapá, Brazil and also as a professor  in the course of Pharmaceutical Sciences and Medicine, Academician of the Brazilian Academy of Pharmacy. He is also ex-rector of the Federal University of Amapá elected for the periods 2006-2010 and 2010-2014; member of the Commission of the Brazilian Pharmacopoeia – ANVISA, Brazil; coordinator of policy support policy of the Brazilian Pharmacopoeia Technical Committee on Medicinal Plants and Herbal – ANVISA, Brazil; member of the Technical Chamber of Herbal Medicines,  ANVISA, Brazil.    

Abstract:

Diabetes mellitus (DM) is a syndrome that reaches more than 382 million people worldwide, it interferes with the metabolism of carbohydrates causing chronic hyperglycemia and generating several complications. Faced with this health problem, the objective of this study was to evaluate the effect of the Copaifera duckei Dwyer oleoresin (OR) on streptozotocin-induced (STZ) diabetic rats. This study was based on the induction of DM by STZ (55 mg/kg i.p) in Wistar rats and treated with doses of OR (250 and 500 mg/kg, v.o). Subsequently, the clinical, biochemical and histopathological of the pancreas parameters were evaluated. Gas chromatographic analysis indicated that β-bisabolene (22.29%), β-caryophyllene (21.25%) and α-farnesene (15.58%) sesquiterpenes were the major components of the OR. In STZ-induced DM, it was possible to observe that the OR treatment had a significant effect (p < 0.001) on the clinical parameters (improving positively). Attenuated the urea, creatinine, and transaminases (AST and ALT) alterations (p < 0,001) observed in animals with DM, as well as, significantly reduced (p < 0.001) values of total cholesterol, triglycerides, and glucose. In the histopathological analyses of the pancreas, it was observed that the OR was able to restore β-cells and increase the quantity and diameter of the Langerhans islets significantly (p < 0.05) when compared to the diabetic group. The treatment with Copaifera duckei Dwyer OR (Copaíba), employed under the conditions of this study, presented antidiabetic activity and can improve the complications found in this syndrome. Possibly the agents responsible for the OR effect are the majority sesquiterpenes.

Biography:

Manal Mohammed is currently pursuing her PhD in Pharmaceutical Chemistry at JSS University, Mysuru, India. Her PhD work focuses on the design and synthesis of novel compounds as histone deacetylase (HDAC) inhibitors for cancer therapy. Her research interests include molecular modeling and in silico design of novel molecules using computational tools. Her research is supported by Department of Science and Technology (DST), Government of India under DST Women Scientist scheme.

Abstract:

Epigenetic regulation of gene expression is explicitly controlled via chromatin remodeling, which in turn is controlled through post-translational modifications (PTM) of histone tails. The known PTMs include acetylation, methylation, phosphorylation, sumoylation, and ubiquitylation. In neoplasms, the mechanism of histone acetylation gets imbalanced through the overexpression of histone deacetylase (HDAC) and/or inactivation of histone acetyl transferase (HAT). Moreover, it extends to a plethora of effects including aberrant gene expression, oncogene activation, tumor suppressor gene inactivation and tumor progression. HDAC inhibitors regulate the gene expression and display anticancer potential. In the present study, a pharmacoinformatic approach was applied to develop a pharmacophore model based on a data set of 42 N-(2-aminophenyl)benzamide analogues reported for HDAC inhibitory profile. The generated model comprised of six chemical points, namely two hydrogen bond donors, two hydrogen bond acceptors and two aromatic rings. The statistically validated model (R2, SD, RCV2, etc) was further employed as a basis to design a library of 138 leads, which was checked for matching fitness against the model. The final hits were selected for chemical synthesis depending on binding interaction(s) after molecular docking, binding free energies and in silico ADME properties. These synthesized hits, containing oxadiazole and thiadiazole heterocycles, were investigated for their in vitro HDAC8 inhibitory and antitumour activity. Among all the compounds, the hydroxamic acid analogue containing p-tolyl substituted thiadiazole displayed better HDAC8 inhibitory potential and significant anticancer activity in comparison to FDA approved HDAC inhibitor, SAHA. These results warrant further investigations to substantiate the compound as a promising drug for treatment of cancer.

Biography:

Dr. R. Suresh Kumar has completed his Ph.D. from Jagadguru Shri Shivaraathreeshwara University Mysuru (JSS University, Mysuru) and he is the coordinator for department of Pharmaceutics in JSS College of Pharmacy, Ootacamund. He has filed 3 Indian patents for his research works. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of reputed journals.

Abstract:

Hemorrhoids are one of the most common ailments where the lowest part of rectum and anus veins are swollen. It is estimated that about 75% of people will have hemorrhoids at some point in their lives. Modern therapies for haemorrhoids include various nonsurgical and surgical options, with a trend towards outpatient procedures and day case surgery. In the present study, we hypothesized that the combination of topical nifedipine to lidocaine loaded nanoemulgel would improve pain control by causing a relaxation of the smooth muscle of the internal anal sphincter where it relieves the symptoms of pain by the effect of analgesic action due to Lignocaine and wound healing by Nifedipine. Initially nanoemulsion was prepared optimized by pseudo tertiary phase diagram. The optimized formulatiom was incorporated to gel base to form nanoemulgel. The formulated Nanoemulgel was smooth, shiny and homogenous with pH of 5.9, viscosity of 3541 cps, spreadability of 40 gm.cm/sec, extrudability of 9 gm/cm² and bioadhesion of 4 kg/cm². Drug content of optimized formulation was found to be 98.17% (Nifedipine) and 97.04% (Lignocaine HCl). In vitro study was performed and the nano emulgel showed a cumulative drug release of 41.12% (Nifedipine) and 45.41% (Lignocaine HCl) at 360 min. The Nano emulgel was found to be stable upon storage for 3 months, no major change was observed in their physical appearance, pH, rheological properties with pharmaceutically acceptable and more economic with improved topical formulations for the treatment of anal fissure for better life of the effected patients.

Biography:

Dr. R. Suresh Kumar has completed his Ph.D. from Jagadguru Shri Shivaraathreeshwara University Mysuru (JSS University, Mysuru) and he is the coordinator for department of Pharmaceutics in JSS College of Pharmacy, Ootacamund. He has filed 3 Indian patents for his research works. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of reputed journals.

Abstract:

Hemorrhoids are one of the most common ailments where the lowest part of rectum and anus veins are swollen. It is estimated that about 75% of people will have hemorrhoids at some point in their lives. Modern therapies for haemorrhoids include various nonsurgical and surgical options, with a trend towards outpatient procedures and day case surgery. In the present study, we hypothesized that the combination of topical nifedipine to lidocaine loaded nanoemulgel would improve pain control by causing a relaxation of the smooth muscle of the internal anal sphincter where it relieves the symptoms of pain by the effect of analgesic action due to Lignocaine and wound healing by Nifedipine. Initially nanoemulsion was prepared optimized by pseudo tertiary phase diagram. The optimized formulatiom was incorporated to gel base to form nanoemulgel. The formulated Nanoemulgel was smooth, shiny and homogenous with pH of 5.9, viscosity of 3541 cps, spreadability of 40 gm.cm/sec, extrudability of 9 gm/cm² and bioadhesion of 4 kg/cm². Drug content of optimized formulation was found to be 98.17% (Nifedipine) and 97.04% (Lignocaine HCl). In vitro study was performed and the nano emulgel showed a cumulative drug release of 41.12% (Nifedipine) and 45.41% (Lignocaine HCl) at 360 min. The Nano emulgel was found to be stable upon storage for 3 months, no major change was observed in their physical appearance, pH, rheological properties with pharmaceutically acceptable and more economic with improved topical formulations for the treatment of anal fissure for better life of the effected patients.

Biography:

Dr. GNK Ganesh has completed his PhD at the age of 38 years from jagadguru sri shivarathreeshwara university, Mysuru. Presently he is working as a professor in  JSS College of Pharmacy, Ooty. He has published more than 30 papers in reputed jounals and has serving as an editorial board member of 3 reputed journal .He has presented many papers in both national and international conferences. He is having more than 15 years experiance in both academic and research

Abstract:

Nano emulsions are the novel carriers which offer major enhancements in therapeutics through site specificity, their capacity to escape from multi-drug resistance and to reduce side effects due to its self-assembled nature that is inherently receptive to its direct environment and the flexibility of the components which can be combined to result in structures with multiple responsive functionalities. The aim of the study was to prepare nano emulsion gel containing Imiquimod by spontaneous emulsification method by using Oleic acid as an oil, Labrasol as a surfactant and PEG-600 as a co-surfactant which found to be compatible by FT-IR. The optimized formulation after thermodynamic studies is subjected for various evaluation. The particle/globule size of optimized formulation was found to be 127 nm with -29 mV zeta potential. The TEM analysis reveals that droplets in the nanoemulsion appear dark and the droplet size was in agreement with the results obtained from droplet size analysis using zetasizer. In-vitro release study using franz-diffusion cells resulted in the cumulative release from nanoemulgel and marketed cream at the end of 24 hrs were 65.12 ± 1.23 and 43.41 ±1.21 respectively and the flux calculation shows the linear drug release of the formulation indicating a zero-order kinetics rather than marketed cream. Percentage haemolysis was found to be less than 5% for formulation and marketed cream. In-vitro cytotoxicity study using HaCat cell lines reveals the IC50 values of the plain drug (IQ), prepared nanoemulgel and marketed cream to be 182.2 μg/ml, 260 μg/ml and 200 μg/ml respectively.

Biography:

Prof. Imran Ali is a world recognized academician and researcher. He completed his Ph.D. at the age of 28 years from Indian Institute of Technology Roorkee, Roorkee, India. Prof. Ali is known globally due his great contribution in anti-cancer and chiral drugs development and water treatment. He has published more than 350 papers in reputed journals including papers in Nature and Chemical Reviews of more than 41 impact factors. He has also five books published by Marcel Dekker, Inc., USA; Taylor & Francis, USA; John Wiley & Sons, USA; John Wiley & Sons, UK; Elsevier, The Netherlands. His citation is 12,000 with H index 46. 

Abstract:

Routine allopathic chemotherapy for cancer treatment has several side and toxic effects. Since long time Unani medicine is being used to cure cancer.  More than twenty Unani herbal drugs are being used for the prevention and treatment of cancer. Several mechanisms are likely to account for the observed pharmacological effects. The most important being direct cytotoxicity, apoptosis induction, antioxidation, and immunomodulation. These Unani herbal drugs may help to synergize the anticancer effects, and reduce the side effects of conventional drugs. The different plants used are dillenia indica, Oroxylum indicum, terminalia arjuna etc. The proposed lecture will comprise the-of-art of Unani medicines in cancer treatment. Besides, the mechanism of action and future perspectives will be discussed.

Biography:

Sahar S Abd El-Rahman is currently a Professor of Pathology, Faculty of Veterinary medicine, Cairo University, Egypt. Dr. Sahar is an active Member in Egyptian Veterinary Medical Society of Pathology and Clinical pathology (EVMS) and Egyptian Veterinary Medical Association (EVMA). She has attended several continued education and technical workshops since, 1993. In addition, she has attended a number of workshops on Quality assurance and Development of Faculty Members. She has joined a number of scientific conferences since 2002, in some of them she was a member of the Organizing Committee. Dr. Sahar has shared in the supervision as well as in the arbitration of a number of master and doctoral theses. She has published about 34 scientific papers, 18 of which were published in international journals. She is a reviewer in a number of international journals and a member of the editorial board in other international journals.

Abstract:

Introduction: AflatoxinB1 (AFB1) is well-known as a feed borne-immunosuppressive mycotoxin. Nanotechnology is a powerful new technology for reconstructing nature at the atomic and molecular level. This study was conducted to determine the efficacy of nano-composite magnesium oxide and silicon oxide (MgO-SiO₂) to reduce the toxic effects of AFB1on the immunity of adult male rats for 8 weeks. Experimental design: Animals were divided into a control (Gp1) and three experimental groups (Gps); Gp2 received feed contained 0.5g/kg nano-composite MgO-SiO₂, Gp3 received feed contained 200ppb/kg AFB1. While rats of Gp4 received feed contained 200ppbAFB1/kg and 0.5g/kg the nano-composite. Methods: Cellular and humoral immune responses, as well as histopathological examination and caspase-3 expression in liver, spleen, and GIT were all evaluated. Residual concentration of AFB1was determined in serum, liver and fecal samples. The obtained data were statistically analyzed. Results: AFB1markedly reduced body weight gain and food and water consumption. Both cellular immune response (total and differential leukocytic count, neutrophils’ phagocytic activity, lymphocyte transformation, macrophage activity and serum lysozyme activity) and humoral immune response (serum total protein and its fractions as estimated by SDS- PAGE electrophoresis) were severely reduced by AFB1. Moreover, AFB1induced marked histological alterations and apoptosis in liver, spleen, and GIT. The addition of nano-composite MgO-SiO₂ to feed containing AFB1 could markedly alleviated the deleterious effects of AFB1. Conclusion: These findings suggested that nano-composite MgO-SiO₂ has high affinity to adsorb AFB1and can effectively modulate its toxicity in rats. Impact statement: Nano-composite MgO-SiO₂ may offer a novel approach for the preventive management of aflatoxicosis in animals.

Biography:

Sherin zakaria has completed her PhD at the age of 32 years from Tanta University . She had started her academic work at Damanhour university. She was the head of quality assurance unit and executive director of SDEE project at faculty of pharmacy, Damanhour university. Recentally, she had moved to Kafer elsheikh university. She had  published more than 10  papers in reputed journals and has been serving as an editorial board member of some journal such as Journal of gastroenterology and hepatology research, American journal of pharmacological sciences and  Tumor biology.

Abstract:

Rebamipide is an antiulcer drug that found to be effective in treatment of chemotherapy induced oral mucositis. This study investigates possible role of keratinocyte growth factor (KGF) and interleukin 10 (IL-10) in rebamipide healing activity. Mucositis was induced by single IP injection of 5- fluorouracil (5-FU) (150 mg/kg). A subsets of 5-FU treated rats were treated with rebamipide suspension (30 mg/kg/ two times a day). Mucositis was assessed according to WHO grading system. Malondialdhyde (MDA), superoxide dismutase (SOD), expression of IL-10, myeloperoxidase (MPO) and KGF was also assessed. Oral mucositis incidence was decreased in Rebamipide treated rats compared to 5-FU. Rebamipide induced a significant (p≤ 0.001) decrease in oxidative markers induced by 5-FU. Rebamipide significantly inhibited expression of MPO (p≤ 0.001) as well as upregulated IL-10 (p≤ 0.01) and KGF (p≤ 0.001) compared to 5-FU. In conclusion, Rebamipide ameliorated 5-FU induced oral mucositis. The healing effect of rebamipide may be due to IL-10 and KGF upregulation.

Biography:

Ms. Mansi Paradkar has completed her M.Pharm (Pharmaceutics) at the age of 24 years from Sardar Patel University. She is currently associated with Department of Pharmaceutics and Pharmaceutical Technology of Ramanbhai Patel college of Pharmacy, CHARUSAT University as an Assistant Professor since 5 years. Her accomplishments in the current organization include supervising nine pharmaceutics projects of Master of Pharmacy students in the area of cerebral malaria, colon cancer, fungal infection, rheumatoid arthritis, emesis by formulating various drug delivery systems including application of nanotechnology. Her research publications are in the journal of 'Drug development and Industrial pharmacy' and 'Saudi Pharmaceutical journal'. One of her research work has been filed for Indian patent.

Abstract:

Artemether (ARM) microemulsion (ME) for intranasal delivery was developed using Isopropyl Myristate (IPM) as oil, Cremophor EL as surfactant and propylene carbonate as co-surfactant by water titration method. The optimized batch ME1 was evaluated by globule size, zeta potential, viscosity, TEM and solubilization capacity.  %In vitro Drug release using modified Franz diffusion cell and histopathological studies from ME1 was carried out through sheep nasal mucosa. Comparative in vivo anti-malarial performance of the developed ME1 was evaluated against the ARM solution and marketed oral ARM formulation (Larither®) Plasmodium berghei infected mice as per Peter’s four day protocol. The parameters studied were %parasitemia, activity against time and animal survival period. TEM micrographs indicated that ME1 had a nearly monodispersed spherical shape with size ranging about 30nm. The mean viscosity of about 106.7cP suggested increased residence time and -18.43±0.86 Zeta potential indicated stability. Significant improvement in drug solubility overcome dissolution rate-limited absorption of ARM and this was realized with higher permeation coefficient during ex-vivo drug release studies. Histological examination of formulations did not show any remarkable damage to nasal mucosa. The animals treated with ME1 exhibited highest reduction in the percent parasitemia and 4 fold higher antimalarial activity with reduced mortality rate as compared to all other groups (P < 0.05). This demonstrates the utility of the microemulsion approach in improving the delivery and therapeutic efficacy of ARM through intranasal administration for the treatment of malaria.

Biography:

Grandhi Surendra has completer PhD from Andhra University in pharmaceutical chemistry Department. He has acquired 9 years of reserach experience and published more than 15 National and International journals, he has also presented a paper at a conference in Malyasia.

Abstract:

Objectives: The aim of the present study was to estimate flavonoid and phenolic content, and to evaluate invitro antioxidant activity of an aqueous extract of Alpinia nigra and Allium tuberosum.
Methods: The air dried stem of A. nigra and leaves of A. tuberosum was ground to powder and extracted with water and 95% of ethanol. The extract was screened for phytochemicals, total phenolic content (TPC) and total flavonoid content (TFC) with its potential antioxidant activities using hydrogen peroxide-scavenging assay.
Results: Phytochemical test shows that extract contains variety of phytochemicals among which there is a high level of total phenol and flavonoids. The total phenolic content (TPC) of A. nigra and A. tuberosum was 0.450±0.0740 and 1.663±0.296; respectively. The total flavonoid content (TFC) of A. nigra and A. tuberosum was 0.322±0.077 and 0.978±0.119, respectively. The plants possessed potent antioxidant activity when compared with the reference compound ascorbic acid (vitamin C).
Conclusions: A. nigra and A. tuberosum may be useful for the preparation of neutraceuticals as potent antioxidant to treat various human diseases and their complications.

Biography:

Jagruti Prajapati has completed her M.Pharm from Maharaja Sayaji Rao Unmiversity of Baroda, Vadodara and pursuing Ph.D and working as Assistant Professor at the age of 27 years from Ramanbhai Patel College of Pharmacy, CHARUSAT, Changa. She has published 5 papers in reputed journals and writing two book chapters in reputed publication.

Abstract:

“Agomelatine” is melatonin receptor (MT1 & MT2) agonist and 5HT2c antagonist, widely used for major depressive episode, absolute bioavailability is <5%. The aim of present study is to develop Agomelatine microemulsion for intranasal delivery, to improve bioavailability. Preformulation study (Purity& Compatibility) was established by Melting point, λmax by UV–Visible spectrophotometry, FTIR, XRD, DSC. Solubility study of drug was conducted in various oils, non-ionic surfactants and co-surfactants. Ternary phase diagrams were constructed to evaluate the microemulsion regions for 1:1, 1:2, 1:3, 2:1, 3:1 of Smix (Chemix). A single isotropic region was found in pseudo-ternary phase diagrams. Microemulsion was formulated by water titration method. Smix ratio 1:1 was selected based on ternary phase diagram and conductivity measurement. In preliminary study, the concentration of oil and Smix were optimized on the bases of globule size. Reported dose of drug is successfully loaded in 0.1ml of ME prepared using optimized oil and Smix concentration range. Microemulsion of Agomelatine was optimized by mixture design of experiment. Prepared microemulsion was characterized by globule size (15 nm), viscosity (80 cps), zeta potential (-47mv) and TEM, Confocal Microscopy Study. In vitro drug release study of pure drug and Agomelatine Microemulsion was performed, in which Agomelatine microemulsion shows 100% Cumulative Drug Release which follows higuchi model. In vivo study (Pharmacokinetic and Pharmacodynamic) was also performed. Pharmacodynamic study was done by Forced Swim test. Pharmacokinetic study revealed that Bioavailability of Agomelatine Microemulsion was increased. Stability study of the same was also performed for heating-cooling cycle, freeze-thaw cycle and centrifugation.

Biography:

Mohamed Mahmoud Elseweidy is a professor of  clinical Biochemistry and clinical nutrition since 1991 at Zagazig University, Egypt. He is also a member of Permanent Scientific Committee (supreme Council of universities, EGYPT) for professors and assistant professors positions (Biochemistry). His research interests include diabetic complications and hyperlipidemia, natural antioxidants and their applications in hyperlipidemia and diabetic nephropathy gastritis, role of Helicobacter pylori and natural products as therapeutic agents. He is a member of American Association for clinical chemistry, American Society for clinical Pathology (ASCP), Egyptian Society for clinical chemistry, Egyptian Society for Pharmaceutical Sciences, Clinical Laboratory Scientist (CLS/ chemistry).

Abstract:

Insulin-degrading enzyme (IDE, insulysin) is a rate–limiting enzyme in the insulin degradation process. It is an intracellular 110-kDa thiol zinc-metalloendopeptidase located in the cytosol, peroxisomes, endosomes and cell surface. IDE catalyzes degradation of several small proteins including insulin, amylin and β-amyloid protein. In addition, insulin clearance was expressed as a target in the treatment of type 2 diabetes given the role of hyperinsulinemia in the pathogenesis of insulin resistance. In this study, fourtyadult male Wistar albino rats were used, thirty rats received 20% fructose in drinking water (HFW) for six weeks to induce diabetes. Subsequently, these rats developed significantly higher body weights, dyslipidemia, hyperglycemia and insulin resistance compared to their controls. Significant increase in the levels of serum glucagon, IDE in liver tissue along with an inhibition of insulin receptor phosphorylation were also observed. Concurrent oral administration of vitamin D3 along with HFW resulted in significant decrease of serum glucose, total cholesterol, triacylglycerol and LDL-C levels. Vitamin D alleviated also insulin resistance, where both IDE, glucagon levels showed significant decrease along with activation of insulin receptor phosphorylation. Normal rats, received vitamin D3 only demonstrated non significant changes of the studied biomarkers. We concluded that vitamin D3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received HFW through reduction of IDE and activation of insulin receptor phosphorylation.

Biography:

Rubab Zohra is working as an associate professor (department of chemistry) in Forman Christian College (A Chartered University), Lahore, Pakistan.

Abstract:

It was planned to synthesize dual-responsive hydrogels from N-isopropyl acrylamide (NiPAAm), acrylic acid (AA) and methacrylate (MA). Hydrogels were prepared by free radical copolymerization using ethyl alcohol as a solvent, a redox initiator, benzoylperoxide (BPO) and ethylene glycol dimethacrylate (EGDMA) and diethylene glycol dimethacrylate (DEGDMA) as cross-linkers. The network parameters like polymer mesh size (ξ) (23.78 to 820 Å), molecular weight between the cross-links (M_c) (970-356096 gmol^-1) and crosslink density (q), (0.0928 to 0.00025) were calculated at various pH using the Flory-Rehner Theory. Hydrogels exhibited the non-Fickian diffusion mechanism. FTIR spectral analysis and (TGA/DSC) were carried out to characterize the systems and new LCST was found to be increased. Tramadol HCl was used as the model drug to investigate the drug loading and unloading behavior of these gels. It was concluded that these systems exhibited a sharp change in their media sorption capacity and mesh size of the networks with the change in the pH and temperature of the swelling media, proposing their strong candidature for being used as oral drug delivery systems. The results favored the idea to apply these hydrogels to use as targeted drug delivery systems for the proximal part of the gastro-intestinal tract.

Biography:

Abstract:

Co-amoxiclav for pediatric use comes as oral powder, which has to be reconstituted before administration. Concerns have been raised regarding the appropriateness of environmental conditions. A stability study was carried out on the original brand (Augmentin) suspension which were reconstituted and kept under the standard storage conditions of 2-8ºC and at home conditions (25ºC). Both compounds (amoxicillin and clavulanic acid) were considered stable if they retained 90% of their initial concentrations. From the study, it was found that the home conditions had no significant detrimental effect on the stability of amoxicillin but had a significant on stability of clavulanic acid, throughout the duration of therapy (10 days). However, the standard storage temperature should be adhered stringently to guarantee maximum therapeutic benefit. This revealed that amoxicillin remained stable throughout the duration of therapy but clavulanic acid did not. Physical compatibility was assessed by visual observation for discoloration and precipitation throughout the duration of therapy. The chemical stability of the drug was analyzed by HPLC instrumental method. The various parameters analyzed include description, odor, color, taste, assay, water content, specific gravity, and pH. These parameters were evaluated at zero day, 3rd day, 7th day, 10th day intervals. The results of assay indicate that the samples are within the allowable limits (90-120%) for amoxicillin at recommended conditions and home conditions, but the storage of augmentin suspension at home conditions (25ºC) showed that the clavulanic acid rapidly exposed to degradation directly after reconstitution of all batches after 3 days, the assay test were out the limit, however when stored at refrigerator temperature (2-8ºC), the degradation of clavulanic acid is very low after prolong period (about 10 days). The results of amoxicillin concentration in all tested batches that were stored at 2-8ºC were very similar to the results of assay that were stored at room temperature.

Biography:

Abstract:

Biography:

Abdullatif Ali Azab was born (1960) in Ara, a famous historical location in Wadi Ara. He completed all his degrees in the Hebrew University of Jerusalem (PhD in medicinal chemistry). After a long career (35 years) in chemical education (high schools and colleges), along with chemical industry (chemical hazardous waste treatment, 6 years), he moved to research of medicinal plant, actually returning to his family traditions, where many of his ancestors were traditional healers. Galilee Society, he is starting now his own Eastern-Plants-Company, which will produce plants based cosmetic and food producs. It will also include research (young Arab researchers) and educational (mainly for high school) divisions. In the mean time, his research continues in the Triangle Research & Development Center (TRDC) of Al-Zahrawi Society (http://www.trd-center.org). Azab has scientific collaborations with well known scholars in Israel and seeking more with the international scientific community, especially in the middle eastern region and the Mediterranean countries. Azab has significant skills in organic synthesis, spectroscopy (especially NMR and GCMS) and vast knowledge of his homeland plants. In 2013 while performing his post doctoral research in the radiology (MRI) department of Hadassah Medicla center of the Hebrew University, he was awarded the Teva (drug company) neuroscience award for an outstanding synthesis protocol of a psychoactive compound. 

Abstract:

Plants are by humans used for medicinal purposes since the dawn of humanity. Among these, plants with anti-inflammatory activity are well known to most cultures, especially the Palestinian traditional medicine which is known for its vastness. However, this ethnomedicine used many plants of different genera to treat inflammations. The methods of herbal treatment were documented or passed verbally through generations. Among these plants, there are well known to other cultures such as Malva sylvestris, Micromeria fruticosa and Salvia officinalis. Expectedly, modern, published research approves this traditional knowledge (Benso, B. et al, 2016; Abu Gharbieh, E. et al., 2013 and Baricevic, D. et al, 2001, respectively). But these are aromatic plants, with very pleasant odors, that are expected to have medicinal activies. Carob (Ceratonia siliqua) is a very well known tree for Palestinian culture, and its very impotrant nutritional resource. Its anti-inflammatory capacities were known and used for centuries, especially against mouth and throat inflammations. But strangely and interestingly enough, the anti-inflammatory of this proven activity was studied just in the last few years (Lachkar, N., et al., 2016; Rtibi, R., et al., 2016). Our current research focuses of other plants that are known to Palestinian ethnomedicine for having anti-inflammatory and other medicinal activities. Currently, we have studied three plants and the results indicate that at least one of them has proven anti-inflammatory activity. Our list includes other 16 plants that were reported to us by local Palestinian people as having such activity. These plants have three common properties: 1) Their anti-inflammatoty potential was never studied and published before. 2) The chemical compositions of all of them are either partially or completely unkown. 3) All of them are known to Palestinian ethnomedicine as having medicinal potential. We will present some plants that Palastenian ethnomedicine use to treat inflammations, published, being studied and with future research plants.

Biography:

Abstract:

Mitoxantrone is an anti-neoplastic anthracenedione derivative that inhibits DNA replication and induces single and double strand breaks by intercalating in DNA through hydrogen bonding. Mitoxantrone is used in the treatment of certain types of cancer such as acute myeloid leukemia and is one of the few drugs approved for the treatment of progressive multiple sclerosis (MS).As a Topoisomerase II (TOP2) inhibitors ,mitoxantrone cause DNA damage in normal cells through apoptosis, mitochondrial dysfunction, free radical generation and lipid peroxidation. Erythropoietin (EPO) is an essential glycoprotein that facilitates red blood cell maturation from erythroid progenitors and mediates erythropoiesis. The use of recombinant human EPO (rHu-EPO) dramatically changed management of anemic patients with chronic kidney disease and improved their quality of life. Besides, recent research’s showed that (EPO) was a major component of tissue-protective system. EPO prevents apoptosis, reactive oxygen species generation and lipid peroxidation process. But the long-term or frequent administration of rHu-EPO due to its short half-life and high doses associated with adverse side effects such arterial hypertension, cerebral convulsion/hypertensive encephalopathy; thrombo-embolism,iron deficiency and influenza-like syndrome. One of the major reasons for the growing interest in nano-drug delivery systems is the potential to generate targeted delivery, decreased in doses and triggered release of drugs to specific cells and tissues. Therefor in this study we report first, the production and characterization of nanoparticles using the ionotropic gelation method between the biopolymer chitosan (CS) and tripolyphosphate (TPP) ion with simultaneous encapsulation of the glycoprotein rHu-EPO and subsequently explore the effect of CS-TPP-EPO nanoparticles in mitoxantrone-induced genotoxicity. For this purpose cells were incubated with regular rHu-EPO and rHu-EPO loading (CS-TPP) nanoparticle and mitoxantrone in pre and co-treatment condition. Our results showed that both regular rHu-EPO and rHu-EPO loading chitosan tripolyphosphate nanoparticles reduced the effects of mitoxantrone significantly by reduction of the level of DNA damage measured with the comet assay.

Biography:

Prakash Kinthada is a Professor in Chemistry at Sri Vidyanikethan Engineering college, JNTU University in Ananthapur, A. Rangam Peta, Tirupathi, India.

Abstract:

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc. My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry, especially Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron,  Nickel, Zinc, Cadmium etc.

The main emphasis of my talk would be on different class of ligands, their Schiff’s bases and transition metal complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing binding sites and diverse strategies employed by my group for elucidation of anti-cancer and anti-HIV drug leads to circumvent the problem caused by Cis-Platin. We have synthesized and characterized several phytochemicals from traditional medicinal plants and isolated some phytochemicals and made the corresponding oximes, thiosemicarbazones and substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their transition metal complexes especially with Gold, Platinum, Palladium, Ruthenium, Copper etc. and studied their anticancer activity, nuclease activity etc. and tested their potential as anticancer drugs. The main aim of our extensive/preclinical pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavanoids etc., which have very interesting structural features and properties and hence are excellent candidates as anti-cancer and anti-HIV drugs. The main aim of our research is design, development and synthesis of transition metal complexes/organometallic compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance cancer killing with less toxic effects and would certainly lead to initiation of clinical trials.

Biography:

Khan’s interests include translation of epidemiological information to national, regional and global disease control policy. His work has focused on generating scientific evidence through basic research, facilitate surveillance networks and promote the use of vaccine to control infectious disease by conducting vaccination demonstration project. His research and work has been regularly published in scientific journals since 2004.

Abstract:

Typhoid vaccines have been available as a means of disease control and prevention since 1896; however, their use as a routine tool for disease prevention in endemic settings has been hampered because of: 1) insufficient data on disease burden particularly regarding the lack of health care access in the poorest communities affected by typhoid; 2) limitations of the typhoid vaccine, such as shorter duration of protection, moderate efficacy in young children, and no efficacy for infants; 3) inadequate evidence on potential economic benefits when used at scale; 4) neglect in favor of alternative interventions that require massive infrastructure; 5) no financial support or commitment regarding vaccine delivery cost; 6) ambivalence about whether to invest in water and sanitation hygiene versus the vaccine; and 7) clarity on global policy for country adoption. The World Health Organization (WHO) in 2008 recommended the use of currently licensed typhoid vaccines using a high risk or targeted approach. The epidemiology of disease and the vaccine characteristics make school-based vaccination most feasible in reducing typhoid disease burden in many settings. To assess feasibility of school-based typhoid vaccination, two districts in Kathmandu, Nepal and two towns in Karachi, Pakistan were selected for pilot program.. In total 257,015 dosesof Vi polysaccharide vaccine were given to students in grades 1–10 of participating schools. The vaccination coverage ranged from 39 percent (38,389/99,503) in Gulshan town in Karachi, to 81 percent (62,615/77,341) in in Kathmandu valley. No serious adverse event was reported post vaccination. The coverage increased in the second phase in Pakistan and Nepal. There was an initial concern of vaccine safety. However, as the campaign progressed, parents were more comfortable with vaccinating their children in schools. Supported and conducted by departments of health in Pakistan and Nepal, a school-based typhoid vaccination was found to be safe and feasible.