R. Sureshkumar
J. S. S. College of Pharmacy, India
Title: E-BABE: A modified formulation approach for the novel combination of Nifedipine and Lignocaine Hcl for the effective treatment of Haemorrhoids
Biography
Biography: R. Sureshkumar
Abstract
Hemorrhoids are one of the most common ailments where the lowest part of rectum and anus veins are swollen. It is estimated that about 75% of people will have hemorrhoids at some point in their lives. Modern therapies for haemorrhoids include various nonsurgical and surgical options, with a trend towards outpatient procedures and day case surgery. In the present study, we hypothesized that the combination of topical nifedipine to lidocaine loaded nanoemulgel would improve pain control by causing a relaxation of the smooth muscle of the internal anal sphincter where it relieves the symptoms of pain by the effect of analgesic action due to Lignocaine and wound healing by Nifedipine. Initially nanoemulsion was prepared optimized by pseudo tertiary phase diagram. The optimized formulatiom was incorporated to gel base to form nanoemulgel. The formulated Nanoemulgel was smooth, shiny and homogenous with pH of 5.9, viscosity of 3541 cps, spreadability of 40 gm.cm/sec, extrudability of 9 gm/cm2 and bioadhesion of 4 kg/cm2. Drug content of optimized formulation was found to be 98.17% (Nifedipine) and 97.04% (Lignocaine HCl). In vitro study was performed and the nano emulgel showed a cumulative drug release of 41.12% (Nifedipine) and 45.41% (Lignocaine HCl) at 360 min. The Nano emulgel was found to be stable upon storage for 3 months, no major change was observed in their physical appearance, pH, rheological properties with pharmaceutically acceptable and more economic with improved topical formulations for the treatment of anal fissure for better life of the effected patients.
