Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 12th Annual
Pharma Middle East Congress Dubai, UAE.

Day 2 :

OMICS International Pharma Middle East 2017 International Conference Keynote Speaker  Raid G Alany photo
Biography:

Professor Raid Alany is a registered New Zealand Pharmacist with a PhD from the University of Otago, Dunedin, New Zealand. He is the Inaugural Head of School of Life Sciences, Pharmacy and Chemistry at Kingston University London, UK; holds an honorary professorship at the University of Auckland, New Zealand. He is the Editor-in-Chief of Pharmaceutical Development and Technology (Taylor and Francis) and Immediate Past President of the New Zealand Chapter of the Controlled Release Society. Raid’s research is on ophthalmic drug delivery, lipid and surfactant-based systems, in-situ gels and animal health. He holds international patents that have been commercialized in New Zealand and Australia where he consults for animal health companies, regulatory bodies and IP-specialized law firms. His research gate score is 35.72 and his h-index is 21 (google scholar).

Abstract:

Oxford dictionary defines research as “the systematic investigation into and study of materials and sources in order to establish facts and reach new conclusions”. Merriam-Webster dictionary defines research as “studious inquiry or examination; especially: investigation or experimentation aimed at the discovery and interpretation of facts, revision of accepted theories or laws in the light of new facts, or practical application of such new or revised theories or laws”.

Academic institutes worldwide consider research a key academic domain and would expect all their academic staff to conduct and engage in research unless they are on a non-traditional contract (teaching fellow, teaching practitioner, demonstrator, hourly paid lecturers etc.). Career progression and promotion in academic institutes involves a thorough and comprehensive review and critique of research outputs. The contribution of a particular academic staff member is assessed; the quality and quantity of journal articles published are scrutinized. Successful publication of scientific outputs is a demanding exercise especially when the target publication medium is a reputable and well established journal.

The aim of this keynote presentation is to shed light on the editorial process involved in reviewing and making editorial  decisions on scientific manuscripts submitted for publication in ‘’Pharmaceutical Development and Technology’’ ; a Taylor and Francis journal that has been in publication for 22 years and has an impact factor of 1.86. An overview of the various metrics used in ranking journals and individual scientific outputs will be covered. Tips on how to prepare a manuscript; to improve chances of success with manuscript submission for publication in leading journals will be given.

OMICS International Pharma Middle East 2017 International Conference Keynote Speaker Heyam Saad Ali photo
Biography:

Prof. Heyam Saad Ali has completed her PhD from Bradford University, UK. She is working as a head of pharmaceutics department, head of quality assurance and auditing  unit  of Dubai Pharmacy college, UAE,  since 2000.She has teaching and research experience of about 25 years. She is a member of various pharmaceutical associations. She contributed more than 50 articles to reputed international scientific journals in different controlled and targeted drug delivery systems.  She has been invited as speaker to numerous International conferences .She is reviewer and member of editorial board of many international pharmaceutical journals.

Abstract:

Cosmetics and personal care products are a diversity set of items commonly use in beauty health and hygiene. Despite the compelling evidence for health impacts in humans and environment of toxicity long term exposure to chemicals in these products, but still remain the excessive items consumption in the world. A growing body of hazard-based evidence suggests connections to long-term health concerns like cancer and reproductive problems. Advertising in the fashion and beauty and the industry misleading claims has effect on women.This presentation will focus on:

  1.   The cosmetic industry’s influence on women.
  2.   Legal standards for Misleading claims and regulatory bodies.
  3.   Harmful effects of using cosmetics.
  4.   List of safest chemicals.
  5.   List of concern.
  6.   Reduction of health environmental impacts of cosmetics. 
  7.  Steps to be taken to reduce toxic exposures & safer alternatives.

  • Sessions:
    Pharmacognosy and Phytochemistry | Nanotechnology | Pharmaceutical Chemistry and Medicinal Chemistry | Green Chemistry in Pharmaceutical Industry | Pharmaceutical Microbiology and Biotechnology | Pharmacological sciences | Biopharmaceutical sciences

Session Introduction

G. N. K. Ganesh

J. S. S. College of Pharmacy, India

Title: Development of nano drug delivey system to treat basal cell Carcinoma
Speaker
Biography:

Dr. GNK Ganesh has completed his PhD at the age of 38 years from jagadguru sri shivarathreeshwara university, Mysuru. Presently he is working as a professor in  JSS College of Pharmacy, Ooty. He has published more than 30 papers in reputed jounals and has serving as an editorial board member of 3 reputed journal .He has presented many papers in both national and international conferences. He is having more than 15 years experiance in both academic and research

Abstract:

Nano emulsions are the novel carriers which offer major enhancements in therapeutics through site specificity, their capacity to escape from multi-drug resistance and to reduce side effects due to its self-assembled nature that is inherently receptive to its direct environment and the flexibility of the components which can be combined to result in structures with multiple responsive functionalities. The aim of the study was to prepare nano emulsion gel containing Imiquimod by spontaneous emulsification method by using Oleic acid as an oil, Labrasol as a surfactant and PEG-600 as a co-surfactant which found to be compatible by FT-IR. The optimized formulation after thermodynamic studies is subjected for various evaluation. The particle/globule size of optimized formulation was found to be 127 nm with -29 mV zeta potential. The TEM analysis reveals that droplets in the nanoemulsion appear dark and the droplet size was in agreement with the results obtained from droplet size analysis using zetasizer. In-vitro release study using franz-diffusion cells resulted in the cumulative release from nanoemulgel and marketed cream at the end of 24 hrs were 65.12 ± 1.23 and 43.41 ±1.21 respectively and the flux calculation shows the linear drug release of the formulation indicating a zero-order kinetics rather than marketed cream. Percentage haemolysis was found to be less than 5% for formulation and marketed cream. In-vitro cytotoxicity study using HaCat cell lines reveals the IC50 values of the plain drug (IQ), prepared nanoemulgel and marketed cream to be 182.2 μg/ml, 260 μg/ml and 200 μg/ml respectively.

Speaker
Biography:

Dr. R. Suresh Kumar has completed his Ph.D. from Jagadguru Shri Shivaraathreeshwara University Mysuru (JSS University, Mysuru) and he is the coordinator for department of Pharmaceutics in JSS College of Pharmacy, Ootacamund. He has filed 3 Indian patents for his research works. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of reputed journals.

Abstract:

Hemorrhoids are one of the most common ailments where the lowest part of rectum and anus veins are swollen. It is estimated that about 75% of people will have hemorrhoids at some point in their lives. Modern therapies for haemorrhoids include various nonsurgical and surgical options, with a trend towards outpatient procedures and day case surgery. In the present study, we hypothesized that the combination of topical nifedipine to lidocaine loaded nanoemulgel would improve pain control by causing a relaxation of the smooth muscle of the internal anal sphincter where it relieves the symptoms of pain by the effect of analgesic action due to Lignocaine and wound healing by Nifedipine. Initially nanoemulsion was prepared optimized by pseudo tertiary phase diagram. The optimized formulatiom was incorporated to gel base to form nanoemulgel. The formulated Nanoemulgel was smooth, shiny and homogenous with pH of 5.9, viscosity of 3541 cps, spreadability of 40 gm.cm/sec, extrudability of 9 gm/cm2 and bioadhesion of 4 kg/cm2. Drug content of optimized formulation was found to be 98.17% (Nifedipine) and 97.04% (Lignocaine HCl). In vitro study was performed and the nano emulgel showed a cumulative drug release of 41.12% (Nifedipine) and 45.41% (Lignocaine HCl) at 360 min. The Nano emulgel was found to be stable upon storage for 3 months, no major change was observed in their physical appearance, pH, rheological properties with pharmaceutically acceptable and more economic with improved topical formulations for the treatment of anal fissure for better life of the effected patients.

Speaker
Biography:

Manal Mohammed is currently pursuing her PhD in Pharmaceutical Chemistry at JSS University, Mysuru, India. Her PhD work focuses on the design and synthesis of novel compounds as histone deacetylase (HDAC) inhibitors for cancer therapy. Her research interests include molecular modeling and in silico design of novel molecules using computational tools. Her research is supported by Department of Science and Technology (DST), Government of India under DST Women Scientist scheme.

Abstract:

Epigenetic regulation of gene expression is explicitly controlled via chromatin remodeling, which in turn is controlled through post-translational modifications (PTM) of histone tails. The known PTMs include acetylation, methylation, phosphorylation, sumoylation, and ubiquitylation. In neoplasms, the mechanism of histone acetylation gets imbalanced through the overexpression of histone deacetylase (HDAC) and/or inactivation of histone acetyl transferase (HAT). Moreover, it extends to a plethora of effects including aberrant gene expression, oncogene activation, tumor suppressor gene inactivation and tumor progression. HDAC inhibitors regulate the gene expression and display anticancer potential. In the present study, a pharmacoinformatic approach was applied to develop a pharmacophore model based on a data set of 42 N-(2-aminophenyl)benzamide analogues reported for HDAC inhibitory profile. The generated model comprised of six chemical points, namely two hydrogen bond donors, two hydrogen bond acceptors and two aromatic rings. The statistically validated model (R2, SD, RCV2, etc) was further employed as a basis to design a library of 138 leads, which was checked for matching fitness against the model. The final hits were selected for chemical synthesis depending on binding interaction(s) after molecular docking, binding free energies and in silico ADME properties. These synthesized hits, containing oxadiazole and thiadiazole heterocycles, were investigated for their in vitro HDAC8 inhibitory and antitumour activity. Among all the compounds, the hydroxamic acid analogue containing p-tolyl substituted thiadiazole displayed better HDAC8 inhibitory potential and significant anticancer activity in comparison to FDA approved HDAC inhibitor, SAHA. These results warrant further investigations to substantiate the compound as a promising drug for treatment of cancer.

Biography:

Rubab Zohra is working as an associate professor (department of chemistry) in Forman Christian College (A Chartered University), Lahore, Pakistan.

Abstract:

It was planned to synthesize dual-responsive hydrogels from N-isopropyl acrylamide (NiPAAm), acrylic acid (AA) and methacrylate (MA). Hydrogels were prepared by free radical copolymerization using ethyl alcohol as a solvent, a redox initiator, benzoylperoxide (BPO) and ethylene glycol dimethacrylate (EGDMA) and diethylene glycol dimethacrylate (DEGDMA) as cross-linkers. The network parameters like polymer mesh size (ξ) (23.78 to 820 Å), molecular weight between the cross-links (Mc) (970-356096 gmol-1) and crosslink density (q), (0.0928 to 0.00025) were calculated at various pH using the Flory-Rehner Theory. Hydrogels exhibited the non-Fickian diffusion mechanism. FTIR spectral analysis and (TGA/DSC) were carried out to characterize the systems and new LCST was found to be increased. Tramadol HCl was used as the model drug to investigate the drug loading and unloading behavior of these gels. It was concluded that these systems exhibited a sharp change in their media sorption capacity and mesh size of the networks with the change in the pH and temperature of the swelling media, proposing their strong candidature for being used as oral drug delivery systems. The results favored the idea to apply these hydrogels to use as targeted drug delivery systems for the proximal part of the gastro-intestinal tract.

Speaker
Biography:

Abstract:

Co-amoxiclav for pediatric use comes as oral powder, which has to be reconstituted before administration. Concerns have been raised regarding the appropriateness of environmental conditions. A stability study was carried out on the original brand (Augmentin) suspension which were reconstituted and kept under the standard storage conditions of 2-8ºC and at home conditions (25ºC). Both compounds (amoxicillin and clavulanic acid) were considered stable if they retained 90% of their initial concentrations. From the study, it was found that the home conditions had no significant detrimental effect on the stability of amoxicillin but had a significant on stability of clavulanic acid, throughout the duration of therapy (10 days). However, the standard storage temperature should be adhered stringently to guarantee maximum therapeutic benefit. This revealed that amoxicillin remained stable throughout the duration of therapy but clavulanic acid did not. Physical compatibility was assessed by visual observation for discoloration and precipitation throughout the duration of therapy. The chemical stability of the drug was analyzed by HPLC instrumental method. The various parameters analyzed include description, odor, color, taste, assay, water content, specific gravity, and pH. These parameters were evaluated at zero day, 3rd day, 7th day, 10th day intervals. The results of assay indicate that the samples are within the allowable limits (90-120%) for amoxicillin at recommended conditions and home conditions, but the storage of augmentin suspension at home conditions (25ºC) showed that the clavulanic acid rapidly exposed to degradation directly after reconstitution of all batches after 3 days, the assay test were out the limit, however when stored at refrigerator temperature (2-8ºC), the degradation of clavulanic acid is very low after prolong period (about 10 days). The results of amoxicillin concentration in all tested batches that were stored at 2-8ºC were very similar to the results of assay that were stored at room temperature.

Speaker
Biography:

Abdullatif Ali Azab was born (1960) in Ara, a famous historical location in Wadi Ara. He completed all his degrees in the Hebrew University of Jerusalem (PhD in medicinal chemistry). After a long career (35 years) in chemical education (high schools and colleges), along with chemical industry (chemical hazardous waste treatment, 6 years), he moved to research of medicinal plant, actually returning to his family traditions, where many of his ancestors were traditional healers. Galilee Society, he is starting now his own Eastern-Plants-Company, which will produce plants based cosmetic and food producs. It will also include research (young Arab researchers) and educational (mainly for high school) divisions. In the mean time, his research continues in the Triangle Research & Development Center (TRDC) of Al-Zahrawi Society (http://www.trd-center.org). Azab has scientific collaborations with well known scholars in Israel and seeking more with the international scientific community, especially in the middle eastern region and the Mediterranean countries. Azab has significant skills in organic synthesis, spectroscopy (especially NMR and GCMS) and vast knowledge of his homeland plants. In 2013 while performing his post doctoral research in the radiology (MRI) department of Hadassah Medicla center of the Hebrew University, he was awarded the Teva (drug company) neuroscience award for an outstanding synthesis protocol of a psychoactive compound. 

Abstract:

Plants are by humans used for medicinal purposes since the dawn of humanity. Among these, plants with anti-inflammatory activity are well known to most cultures, especially the Palestinian traditional medicine which is known for its vastness. However, this ethnomedicine used many plants of different genera to treat inflammations. The methods of herbal treatment were documented or passed verbally through generations. Among these plants, there are well known to other cultures such as Malva sylvestris, Micromeria fruticosa and Salvia officinalis. Expectedly, modern, published research approves this traditional knowledge (Benso, B. et al, 2016; Abu Gharbieh, E. et al., 2013 and Baricevic, D. et al, 2001, respectively). But these are aromatic plants, with very pleasant odors, that are expected to have medicinal activies. Carob (Ceratonia siliqua) is a very well known tree for Palestinian culture, and its very impotrant nutritional resource. Its anti-inflammatory capacities were known and used for centuries, especially against mouth and throat inflammations. But strangely and interestingly enough, the anti-inflammatory of this proven activity was studied just in the last few years (Lachkar, N., et al., 2016; Rtibi, R., et al., 2016). Our current research focuses of other plants that are known to Palestinian ethnomedicine for having anti-inflammatory and other medicinal activities. Currently, we have studied three plants and the results indicate that at least one of them has proven anti-inflammatory activity. Our list includes other 16 plants that were reported to us by local Palestinian people as having such activity. These plants have three common properties: 1) Their anti-inflammatoty potential was never studied and published before. 2) The chemical compositions of all of them are either partially or completely unkown. 3) All of them are known to Palestinian ethnomedicine as having medicinal potential. We will present some plants that Palastenian ethnomedicine use to treat inflammations, published, being studied and with future research plants.

Speaker
Biography:

Prakash Kinthada is a Professor in Chemistry at Sri Vidyanikethan Engineering college, JNTU University in Ananthapur, A. Rangam Peta, Tirupathi, India.

Abstract:

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc. My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry, especially Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron,  Nickel, Zinc, Cadmium etc.

The main emphasis of my talk would be on different class of ligands, their Schiff’s bases and transition metal complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing binding sites and diverse strategies employed by my group for elucidation of anti-cancer and anti-HIV drug leads to circumvent the problem caused by Cis-Platin. We have synthesized and characterized several phytochemicals from traditional medicinal plants and isolated some phytochemicals and made the corresponding oximes, thiosemicarbazones and substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their transition metal complexes especially with Gold, Platinum, Palladium, Ruthenium, Copper etc. and studied their anticancer activity, nuclease activity etc. and tested their potential as anticancer drugs. The main aim of our extensive/preclinical pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavanoids etc., which have very interesting structural features and properties and hence are excellent candidates as anti-cancer and anti-HIV drugs. The main aim of our research is design, development and synthesis of transition metal complexes/organometallic compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance cancer killing with less toxic effects and would certainly lead to initiation of clinical trials.

Biography:

Khan’s interests include translation of epidemiological information to national, regional and global disease control policy. His work has focused on generating scientific evidence through basic research, facilitate surveillance networks and promote the use of vaccine to control infectious disease by conducting vaccination demonstration project. His research and work has been regularly published in scientific journals since 2004.

Abstract:

Typhoid vaccines have been available as a means of disease control and prevention since 1896; however, their use as a routine tool for disease prevention in endemic settings has been hampered because of: 1) insufficient data on disease burden particularly regarding the lack of health care access in the poorest communities affected by typhoid; 2) limitations of the typhoid vaccine, such as shorter duration of protection, moderate efficacy in young children, and no efficacy for infants; 3) inadequate evidence on potential economic benefits when used at scale; 4) neglect in favor of alternative interventions that require massive infrastructure; 5) no financial support or commitment regarding vaccine delivery cost; 6) ambivalence about whether to invest in water and sanitation hygiene versus the vaccine; and 7) clarity on global policy for country adoption. The World Health Organization (WHO) in 2008 recommended the use of currently licensed typhoid vaccines using a high risk or targeted approach. The epidemiology of disease and the vaccine characteristics make school-based vaccination most feasible in reducing typhoid disease burden in many settings. To assess feasibility of school-based typhoid vaccination, two districts in Kathmandu, Nepal and two towns in Karachi, Pakistan were selected for pilot program.. In total 257,015 dosesof Vi polysaccharide vaccine were given to students in grades 1–10 of participating schools. The vaccination coverage ranged from 39 percent (38,389/99,503) in Gulshan town in Karachi, to 81 percent (62,615/77,341) in in Kathmandu valley. No serious adverse event was reported post vaccination. The coverage increased in the second phase in Pakistan and Nepal. There was an initial concern of vaccine safety. However, as the campaign progressed, parents were more comfortable with vaccinating their children in schools. Supported and conducted by departments of health in Pakistan and Nepal, a school-based typhoid vaccination was found to be safe and feasible.