Biography
Biography: Soumen Pattanayek
Abstract
Osmotic systems are the most reliable controlled drug delivery systems (CDDS) and can be employed as oral drug delivery systems. Osmotic pressure is used as the driving force for these systems to release the drug in a controlled manner. Osmotic pump tablet (OPT) generally consists of a core including the drug(s), an osmotic agent, other excipients and semipermeable membrane coat. Osmosis is an aristocratic phenomenon that seizes the attention for its exploitation in zero-order drug delivery systems. It acts as the driven force for release of drug from the dosage form. The osmotic tablet worked on the principle Osmosis i.e. movement of water across a selectively permeable membrane driven by a difference in osmotic pressure across the membrane. It is driven by a difference in solute concentration across the membrane that allows passage of water but rejects most solute molecules or ions. On the basis of this principle, osmotic drug delivery gives better drug release, not depends on the concentration of the drug and better results than any other controlled release system. Controlled drug release systems attempt to sustain drug action at a predetermined rate by maintaining a relatively constant, effective drug level in the body with minimization of undesirable side effects. In oral NDDS, the development of the Osmotic drug delivery system is a significant milestone for an innovative and highly versatile drug delivery system.