Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 18th Annual Pharma Middle East Congress Abu Dhabi, UAE.

Day 2 :

  • Pharmacognosy
Location: Abu Dhabi
Speaker
Biography:

Howaida I. Abd-Alla, Ph.D., specializes in metabolomics natural products chemistry and completed her PhD at the University of Cairo in 2004. After spending time as a postdoctoral fellow at Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, Université de Toulouse, France, she became a professor in the Chemistry of Natural Compounds Department, National Research Centre, Egypt. Currently, she is working as the head of the department where her research focuses primarily on isolation, purification and identification of natural compounds from medicinal plants, bacteria and marine organisms using advanced techniques for identification (1D and 2D NMR analysis), synthesis of derivatives of natural products, and bioactive assays in vivo and in vitro in natural products for use in treating different diseases.

Abstract:

Analyzing the lipid and protein content of leaves and roots of Aloe barbadensis collected from Egypt (AEG) and Tunisia (ATUN) was carried out using by GLC and HPLC respectively. The HSV-1 infected chicken embryo fibroblasts cell lines were used for evaluation of the in vitro antiviral effect. A rapid and high frequency shoots multiplication, rooting and acclimatization protocols for elite Aloes using shoot tip explants were developed. Preliminary comparative molecular screening in vitro propagated aloes was carried out and randomly amplified polymorphic DNA (RAPD) markers have been used to check for genetic fidelity of aloes plantlet. Shoot tips explants of the two types were cultured on Murashige and Skoog’s (MS) basal medium supplemented with different plant growth regulators TDZ, BAP, NAA for shoots proliferation and roots formation. After two weeks, in vitro grown plants were transferred to the poly-cups containing 1:1 ratio of soil and sand respectively for hardening and then transferred to garden showed 75% of survival. The DNA fingerprint genetic integrity of the multiplied shoots and acclimatized plantlets were evaluated by employing RAPD marker assays. There was great variability in chemical constituents of AEG and ATUN. All the tested samples showed effective antiviral activity with IC50 range of 5-6 µg/mL and substantial therapeutic indices (TI) range of 80 - 83. Cytotoxicity assay indicated that CC50 of leaves and roots of AEG and ATUN were greater than 400 and 500 mg/mL, respectively. Shoot proliferation was found to be best (80%) using MS medium containing BAP 2.0 mg/L. Moreover, second subcultures recorded the highest and significant shooters multiplication. Seventy percent of adventitious root formation was observed in half strength MS medium supplemented with IBA. Over 95% of rooted plantlets survived acclimatization was remarked. The current results indicated that the geographical localization had the significant impact on the quality of each Aloe.

 

Speaker
Biography:

Gehan Fawzy Abdel Raoof has completed her PhD in 2015 from Faculty of Pharmacy, Cairo University. She is a researcher at Pharmacognosy Department, Pharmaceutical and Drug Industries Research Division, National Research Centre Giza, Egypt.  She has published many papers in international journals and has been serving as a reviewer member in many journals. She is a member of Organization for Women in Science for The Developing World (OWSD) and a member of International Scientific Committee of World Academy of Science, Engineering and Technology (WASET).

Abstract:

Statement of the Problem: Pleiogynium timorense(DC.) Leenh is one of the therapeutically active plants belonging to the family Anacardiaceae. The bark of Pleiogynium timorense needs further studies to investigate its phytochemical and biological activities. This work was carried out to investigate the chemical composition of petroleum ether extract of Pleiogynium timorense bark as well as to evaluate the analgesic and anti-inflammatory activities. Methodology & Theoretical Orientation: The unsaponifiable matter and fatty acid methyl esters were analyzed by GC-MS. Moreover, analgesic and anti-inflammatory activities were evaluated using acetic acid-induced writhing test and carrageen hind paw oedema models in rats, respectively. Findings: The results showed that twenty-one compounds in the unsaponifiable fraction were identified representing 92.54 % of the total beak area, the major compounds were 1-Heptene (35.32%), Butylated hydroxytoluene (19.42%) and phytol (12.53%), whereas fifteen compounds were identified in the fatty acid methyl esters fraction representing 94.15% of the total identified peak area.  The major compounds were 9-Octadecenoic acid methyl ester (35.34%) and 9,12-Octadecadienoic acid methyl ester (29.32%). Moreover, petroleum ether extract showed a significant reduction in pain and inflammation in a dose-dependent manner.

  • Pharmaceutical Chemistry
Location: Abu Dhabi
Speaker
Biography:

Prakash.M.M.S Kinthada, is a Professor in the Department of Chemistry at Sri Vidyanikethan Engineering college, Jawahar Lal Technological University, Anantapur, A. Rangam Peta, Tirupathi, India. Earlier I was an Associate Professor of Chemistry, GIT, Gitam University, Visakhapatnam, India. I have recently returned from the USA, where I was an NIH visiting fellow at Karmanos Cancer ReseaInstitutetee, Wayne State University School of medicine. Earlier I was a Royal Society Visiting Scientist in the inorganic chemistry laboratories at the University of Oxford, UK, working on" Transition metal complexes as Anticancer Drugs". Earlier I was a visiting fellow at the Department of ChemicalEngineering and Applied Chemistry at Aston University, Birmingham. Prior to that, I was a Nehru Centenary British Council Fellow in the organometallic laboratories at the Imperial College of Science, Technology and Medicine, London, UK. Prior to that, I was a CSIR Research associate in the Organometallic laboratories, Department of chemistry, Indian Institute of Technology, New Delhi India. I have published all my research in high impact international journals and Presented paper in International Conferences including American Chemical society conferences. I have published 33 International publications and 31international conference presentations including American ChemicalSociety conferences.

Abstract:

The main aim of our extensive/preclinical Pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavonoids etc., which have very interesting structural features and properties and hence are excellent candidates as Anti-Cancer and Anti-HIV drugs. The main aim of our research is Design, Development and Synthesis of Transition Metal Complexes/ Organometallic Compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance Cancer Killing with less toxic effects and would certainly lead to the initiation of clinical trials. Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug-induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum-based drugs and Non-Platinum based drugs is a Multi-Million Dollar Industry in the USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. 

Speaker
Biography:

Anteneh Assefa (B.Pharm, MSc), is a Lecturer of Pharmaceutics & Pharmacology, Wachemo University. He is the expertise of pharmaceutical dosage form design and drug supply chain management. He has due experience of delivering pharmaceutical service to patients at hospitals, forecasting, quantifying and distribution of pharmaceuticals and medical equipment to health facilities and delivering/ instructing and training students and health care providers. Currently, he is offering various pharmaceutics and pharmacology courses to the pharmacy and other medical students; besides he is working on various basic and applied researchers. He is serving as Head of School of Pharmacy. 

Abstract:

Starch is the most commonly used pharmaceutical disintegrant in tablet formulations. The aim of the present study was to assess the disintegrant property of Ethiopian potato (Plectranthus edulis) starch in comparison to Irish potato starch and its optimization in paracetamol tablets formulations - prepared by wet granulation method. Tablet properties such as crushing strength, friability, disintegration time, and dissolution rate of the tablets were studied for both comparison and optimization studies. The results of comparative study showed that the properties of paracetamol tablets formulated with both starches as disintegrants were affected by their concentration and the compression force (CF); and P. edulis starch exhibited a favorably comparable disintegrant property with Irish potato starch in paracetamol tablet formulations. The study also showed that the CF and disintegrant concentration had significantly affected the response variables (i.e., the crushing strength, friability and disintegration time); hence, these factors were further optimized using central composite statistical design.

  • Pharmaceutics
Location: Abu Dhabi
Speaker
Biography:

Syed Muzammil Afzal has completed his PhD from Kakatiya University, Warangal, India. He has more than a decade of teaching and research experience. His research interest includes the development of lipid nanoemulsions for a tumour & brain targeting, development & evaluation of novel drug delivery systems like Nanoemulsions, Nanoparticles, etc. He has published 12 papers in reputed journals and presented research findings at various national & International conferences. He is the reviewer for the Journal of drug targeting. He is a recipient of UGC, AICTE fellowships awarded by the Government of India. He is the CPCSEA Nominee selected by Ministry of an environment, Government of India. Presently, he is Associate Prof & Head of Pharmaceutics in Sri Shivani College of Pharmacy, India.

Abstract:

The aim was to develop tumour-targeted docetaxel lipid nanoemulsions with four strategies for improving the antitumor activity and compare their targeting efficiencies. The O/W lipid nanoemulsions (L), were prepared by homogenization followed by ultrasonication process. The size of globules and zeta potential were measured by Malvern Zetasizer. The drug content and entrapment efficiencies for the lines were determined by HPLC. The in-vitro cytotoxic studies of the delivery systems were performed on MCF-7 and HeLa cells. The IC50 values of targeted lines on both the cell lines were statistically significant (P<0.05) when compared to DS (Docetaxel solution) & DLNE (Docetaxel LNE). The in-vivo antitumor activity was tested on solid tumours induced in C57BL/6 mice. This study revealed that the percentage a tumour inhibition, when compared with the control (untreated), were found to be 55.62%, 70.80%, 89.31%, 54.25%, 80.0% and 84.66% for the DLNE, PLNE, FLNE,SALNE, ALNE and TFLNE formulations respectively. Further, in-vivo distribution studies were carried out in breast cancer, MDA-MB231 induced tumours in Balb/c mice. The LNEs were loaded with fluorescent DiD oil and the distribution in different organs after 6hrs was tracked by small animal in-vivo imaging system. When compared with the DLNE the average radiance values at the tumour site for the formulations PLNE, FLNE, SALNE, TFLNE and ALNE were found to be increased by 2.31, 4.81, 1.35, 3.54 and 3.04 folds respectively. The tumour targeting efficiency was found to be in the order FLNE> TFLNE>ALNE> PLNE>SALNE>DLNE by an imaging study.