Ibrahim Elsayed
Gulf Medical University, UAE
Title: Lipotomes: A Novel Nanovesicular Platform for Enhanced Oral and Transdermal Drug Delivery
Biography
Biography: Ibrahim Elsayed
Abstract
Lipotomes is novel lipid-based nanocarriers composed of cetyl alcohol and a surfactant such as Tween 80. Lipotomes combine the lipophilic environment of cetyl alcohol and solubilizing effect of Tween 80 and so, it offers a dual action for increasing drug bioavailability. Consequently, lipotomes could be the key tool for the bioavailability enhancement of water-insoluble drugs suffering from a significant inactivation by the first pass effect. Moreover, prolipotomes has been developed to increase its physical stability through out the shelf-life. Prolipotomes are hydrated after administration to form the lipotomal nanovesicles in situ. On the other hand, lipotomes can enhance transdermal delivery of wide range of drugs due to its nano-size and the presence of Tween 80 that can act as a physical penetration enhancer through disrupting the lipid layers of the skin.