Kriti Ray
Deakin University, Australia
Title: Development of a reporter assay to determine the bioactivity of anti-IL6/IL6R and anti-EGFR based monoclonal antibodies
Biography
Biography: Kriti Ray
Abstract
Aim of the study: Biopharmaceuticals will comprise around 27% of the global pharmaceutical market in the near future, and monoclonal antibodies (mAbs) are predicted to take the major share due to their favourable drug properties such as specificity, high efficacy and fewer side-effects. Hence, testing mAbs for their efficacy and stability before batch release is an important aspect of the mAb development and manufacturing program. Here, we aim to design and validate an in-vitro reporter gene-based assay for the evaluation of anti-IL6/IL6R and anti-EGFR mAbs with immense therapeutic potential and to make the stability testing procedure more robust, precise and rapid in comparison to existing assays.