Anteneh Assefa
Wachemo University, Ethiopia.
Title: Comparative Disintegrant Properties of Ethiopian Potato (Plectranthus edulis) Starch against Irish Potato Starch and its Optimization in Paracetamol Tablet Formulations
Biography
Biography: Anteneh Assefa
Abstract
Starch is the most commonly used pharmaceutical disintegrant in tablet formulations. The aim of the present study was to assess the disintegrant property of Ethiopian potato (Plectranthus edulis) starch in comparison to Irish potato starch and its optimization in paracetamol tablets formulations - prepared by wet granulation method. Tablet properties such as crushing strength, friability, disintegration time, and dissolution rate of the tablets were studied for both comparison and optimization studies. The results of comparative study showed that the properties of paracetamol tablets formulated with both starches as disintegrants were affected by their concentration and the compression force (CF); and P. edulis starch exhibited a favorably comparable disintegrant property with Irish potato starch in paracetamol tablet formulations. The study also showed that the CF and disintegrant concentration had significantly affected the response variables (i.e., the crushing strength, friability and disintegration time); hence, these factors were further optimized using central composite statistical design.