Genetics in Drug Discovery and Development

The genomics revolution, which appears to have infiltrated all biological and biomedical sciences, has produced the most astounding breakthroughs in pharmaceutical sciences. Technological advances in high-throughput DNA sequencing, assessing gene expression for thousands of transcripts, and using RNA constructs to silence specific genes have not only fueled genomic research, but have also contributed to an emerging paradigm shift in pharmacology, drug development, and pharmacotherapeutics. The availability of molecular tools in laboratories has accelerated the transition from medication development based mostly on chemistry to one based on our growing biology understanding of the physiological and molecular effects of substances. With these technologies, it is now possible to examine the nature of drug action, toxicity, and tolerance at the cellular level. Similarly, our understanding of human disease is improving, which will lead to more accurate therapeutic approaches based on more exact disease states.

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