Scientific Program

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Day 2 :

Keynote Forum

Dong-Kwon Rhee

Sungkyunkwan University, South Korea

Keynote: Korean red ginseng as an anti-stress immune-potentiator via ER-β modulation

Time : 09:30-10:00

OMICS International Pharma Middle East 2016 International Conference Keynote Speaker Dong-Kwon Rhee photo
Biography:

Dong-Kwon Rhee has completed his PhD at University of Illinois at Chicago in 1988 and Postdoctoral studies from Yale University School of Medicine. He was the Director of World Class University at Sungkyunkwan University (SKKU) one of the fastest rising universities in the World and School of Pharmacy. He has published 159 papers in reputed journals and is serving as a President of Korean Society of Ginseng.

Abstract:

Panax ginseng C.A. Meyer has long been used in Asian countries for stimulating immunity and inhibiting various cancers. Although the role of ginseng in regulating the development of cancer is well defined, the mechanisms by which it protects brain cells from oxidative stress or immune cells from lethal pneumococcal infections is not well understood. Since brain myelin sheaths contain relatively large amounts of iron and lipids and have high rates of oxidative metabolism with limited antioxidant capacity, brain is highly susceptible to oxidative damage. Although P.ginseng has been advocated to have adaptogenic activity, how P.ginseng can modulate biological activities remains largely unknown. Here we show that P. ginseng might exert adaptogenic activity via ER-β modulation. Korean Red Ginseng (KRG) extract was shown to inhibit oxidative stress-induced apoptosis in brain cells by ER-β up-regulation via the PI3K/AKT signaling pathway. The up-regulation of PI3K/AKT signaling inhibited apoptotic signals by decreasing p-p53 and caspase-3 expression, but increasing BCL2 expression. Therefore, KRG protected brain cells from oxidative stress-induced cell death. Pre-treatment of KRG protected the mice from lethal D39 pneumococcus infection and protected mice from pneumococcal sepsis and meningitis. In pneumococcal meningitis model, KRG pretreatment has up-regulated ER-β in mice brain. Also, when Raw264.7 macrophage cells were infected with pneumococcus, expressions of Toll-like receptor 4 and TNF-α were significantly induced, whereas they were significantly diminished by KRG pre-treatment in vitro. Taken together, KRG seems to repress expression of inflammation related genes, clear bacteria, and enhance mice survival via ER-β up-regulation in the brain.

 

 

 

OMICS International Pharma Middle East 2016 International Conference Keynote Speaker P G Shrotriya photo
Biography:

P G Shrotriya has worked for over four decades in every facet of Pharma industries in India and overseas and was responsible for achieving international quality compliance and approvals for number of organizations. He has worked for number of WHO standards for drugs and pharmaceuticals. He was the Chairman for Parenteral Preparation in Indian Pharmacopoeia, Government of India and delivered several lectures at national and international levels. He is working with academic institutes and training students and professionals from industry and regulatory agencies for international regulatory compliance.

Abstract:

Pharmaceutical Industry has made phenomenal progress with safety efficacy of drugs and Pharmaceuticals. Innovation has made significant contribution to patient care with high level of success. Though withdrawal of 60 new drugs over a period of about 50 years due to inadequacy on safety front, has mad new drug introduction with a couscous approach. Several innovations have restored confidence in capability of industry. Resistance developed by microbes to several antibiotics has retarded introduction of newer drugs to combat resistant microbes. It is a war situation between microbes and mankind. Use of bio-enhancers of natural origin has significantly contributed to counter resistant strains. Beside this, increased solubility and permeability has also contributed to practicability to reduce the effective dose of antibiotics there by reducing the adverse drug reactions. Nanotechnology has revolutionized the drug delivery systems in nanoparticle size improving solubility and permeability of drug to facilitate therapeutic efficacy in large number of drug therapy. This technology has opened up large vistas of new drug delivery systems, newer approach to patient care, diagnostics, lab on a chip to bring superior patient care at a door step with use of IT. Regenerative medicines with special reference to stem cells (Stemceuticals) have significantly improved life span of patients in last one and half decades. Their availability in human body has generated expertise in combating some of the terminal cases with newer vision in therapy. Innovations in Pharmaceutical Sciences have made it mandatory to adopt multidisciplinary approach in drug development and patient care. It has contributed from Mega to Terabyte pace approach. Like in any innovative technology, risk and responsibility also demand attention of professionals. The address will cover some of the important contribution of innovations.

  • Pharmacognosy and Phytochemistry | Genetics, Genetic Engineering and Biomedical Engineering | Ethics in Pharmacy | Pre formulation Study & Techniques | Clinical Pharmacy and Pharmacotherapeutics
Location: Salon VI & VII, JW Marriott Dubai, UAE
Speaker

Chair

Mohamed N

Princess Nourah Abdulrahman University, KSA

Speaker

Co-Chair

Amna Beshir Medani Ahmed

Nile College of Pharmacy, Sudan

Speaker
Biography:

Cathrine Victor Gabra Boutros had completed her Master Degree in Clinical Pharmacy at the age of 23 years from University of Medical Sciences and Technology. She was appointed as a lecturer of Pharmacology and Clinical Pharmacology at University of Medical Sciences and Technology from 2011 up to 2015. Currently, she is working as a lecturer of Pharmacology and Communication Skills at Nile College. She had published a paper entitled “Epidemiology of substance use among University students in Sudan” in Journal of Addiction, January 2016.

Abstract:

Background Ocular pharmacology is one of the least-managed areas of pharmaceutical care by pharmacists, however, pharmacists play a major role in health promotion towards eye care, they are in a position to advice patients upon the symptoms presented and demonstrate the proper use of ophthalmic drops and ointments. The challenge is to create a new generation of ocular pharmacists who can improve eye care treatment in managed care pharmacy. Objective: This study aims to assess the knowledge, attitude and practice of pharmacists towards ophthalmic medications. Method: The study was conducted using two methods, the mystery shopper and conventional questionnaire methods for getting the actual and perceived knowledge, attitude and practice (KAP) respectively. The study was carried out on randomly selected pharmacies (n= 100) in Khartoum. In collecting data of the actual pharmacist’s (KAP), four scenarios were done by a mystery shopper. The observations were reported immediately after each visit using an observational checklist. In collecting the perceived data of the pharmacist’s (KAP), a conventional questionnaire was designed and distributed to the same pharmacists . The actual and perceived data collected, was analyzed using SPSS. Results: The results collected by the mystery shopper showed that overall performance- including knowledge, attitude and practice- of the studied group of pharmacists was generally poor representing 47% of the total, 38% were average, and only 15% were good. However the questionnaire results was somehow better, as 43% were poor, 28% were average, and 29% were good. Actual data collected by the mystery shopper showed that in scenario one, none of the pharmacists recognized the inappropriate use of tropicamide eye drop in glaucomatous patients, and only 20% (n=5) could recognize the best time for using travoprost eye drop is at evening. In scenario two, only 20% (n=5) could recognize that acyclovir ophthalmic ointment should be used five times a day. Results of scenario three, showed that the majority of the pharmacists 32% (n= 8) provided tetracycline eye ointment for the treatment of acute bacterial conjunctivitis in infants, 36% (n= 9) referred to an ophthalmologist. Scenario four, showed that none of the pharmacists were aware of mast cell stabilizer and its indication as a prophylactic of allergic conjunctivitis. The perceived data collected by the questionnaire showed a better results as the pharmacists were trying to give an ideal answers knowing that they were a part of an assessment study. Conclusion: Pharmacists were found to had poor knowledge, attitude and practice about ophthalmology and its medications. It is recommended to consider curriculum modifications to facilitate learning outcomes needed to practice pharmaceutical care specially in the ophthalmic area.

Speaker
Biography:

Amna Beshir Medani has completed her PhD from University of Khartoum and Post-doctoral studies from University of Khartoum, School of Veterinary Medicine. She is an Assistant Profesor of Pharmacology and Toxicology UMST, Faculty of Pharmacy, a premier founder of Toxline.org, and a member of many international organizations and bodies. She has published more than 13 papers in reputed journals and conferences and has been serving as an Editorial Board Member of repute.

Abstract:

The effects of oral doses of polyDADMAC were daily examined on Nubian goats at two different dose-rates, namely 0.5 mg/kg/day and 2.5 mg/kg/day to group (2) and (3) goats respectively compared to untreated Nile water given to a group (1) of control goats under experimental conditions. Death occurred to variable levels. In polyDADMAC dosed animals clinical signs included dullness, loss of weight, loss of appetite, diarrhea, difficulty in respiration, and recumbence. Postmortem changes included haemorrhagic and congested lungs, congested livers, inflamed intestines in addition to bloated rumens and their kidneys showed fatty changes Oral dosing with polyDADMAC caused lung emphysema ,lymphocyte infiltration and edema. Intestines showed congestion and sloughing of intestinal epithelium, their livers manifested generalized fatty change and lymphocyte infiltration and spleens suffered from haemosiderosis, while the control goats showed normal clinical , postmorteum and histopathological picture. The serum concentrations of GPT, LDH , CK and GOT showed variable changes (P<0.01-P<0.001). Serum metabolites significantly increased (P<0.01) –P<0.01) in urea and creatinine values compared to the control group . Deviated values of electrolytes in serum (P<0.01-P<0.001) from the control values namely, magnesium, iron, sodium, potassium, calcium and phosphrus. Other hematological disorders were manifested mostly by the group of goats received the highest dose. Hepatic and renal dysfunctions, as a sequel to treatment with the under-test polymer, were observed forming a co-related picture which expresses its toxic and sometimes lethal effects.

Speaker
Biography:

P G Shrotriya MPharm, PhD worked for over four decades in every facet of Pharma Industries in India and overseas and was responsible for creating international quality compliance and approvals for number of organizations. He was Chairman Parenteral Preparation in Indian Pharmacopoeia, Govt. of India. He worked for number of WHO standards for Drugs and Pharmaceuticals. He delivered lectures at national and international levels. He was working with academic institutes and trained students and professionals for International Regulatory Compliance.

Abstract:

Pharma industry is heavily regulated all over the world, rightly so since it deals with human lives. Need for strict regulation was realised and implemented world over after havoc created by Thalidomide. Over a period of three decade industry has seen phenomenon change in acceptance standards of International Regulatory Agencies world over. Setting up of Standards for Organization and preparing Organization for International Regulatory Compliance is a big task for Pharma Industry who would like to be a Global player in manufacturing and Supply Chain Management of Drugs and Pharmaceuticals. Top Management commitment is a must for excellence in Quality System. Support for creating hardware is not enough, where human being plays a major role. Regulatory compliant facility must be supported by a Quality system which has to be made as a culture, a way of working. Dual standards – one for the country and another for Regulated Market does not work. Acceptance level and ensuring adherence to controls is a task to be complied with by every individual. This presentation will cover importance of continuous Training, Development and Monitoring at a regular interval and updating of systems. Scientific Investigation of every observation in a situation and that by International Regulatory Agency will be presented as Case studies – i) Noncompliance to Environmental Controls in a recently completed maintenance of parenteral manufacturing facility. ii) Compliance to Validation requirements in changeover to high speed operation insisted by a Regulatory Agency. iii) Abnormal odour experienced in a bulk pack of Anti-TB drug product supplied to International Regulating Agency. iv) Role of Package design and Environmental control for Antibiotic Suspension – Investigation to Solution. v) Recreating market complaint referred by Importing Regulatory Agency. vi) Issue of not meeting the requirement of weight of content of Capsule referred by a QP of a regulated market.

Speaker
Biography:

Abstract:

Background Antimicrobial resistance is an emerging global public health problem. Countries of the deve-loping world are mostly affected and Sudan is included. The most serious concern is that some bacteria acquire resistance to almost all routinely used antibiotics. Such bacteria are capable of causing serious infections that are very difficult to treat. We, therefore, were interested in studying the existence and extent of antimicrobial resistance in clinically isolated bacteria. Objectives We aim at studying the antimicrobial susceptibility pattern of a group of pathogenic aerobic bacteria that are isolated from patients suffering from infectious conditions and attending different hospitals in Khartoum city. Methodology This is a laboratory-based descriptive study. Clinical isolates were collected from patients attending Soba, Khartoum, Omdurman Paediatric, Omdurman Emergency and Al-Zaytona hospitals in addition to the Jordanian medical centre. Standard bacteriological protocols and the Modified Kirby-Bauer Disc Diffusion assays were applied. The ethical clearance for conducting this study was obtained from the Ethical Committee Board of UMST and hospitals authorities. Results Out of 150 isolates; 130 [87%] were Gram negative, these included; Escherichia coli [55, 36%], Klebsiella pneumonia [36, 24%], Proteus spp {[24, 16%]: Proteus mirabilis [13, 54%] and Proteus vulgaris [11, 46%]}, Enterobacter spp [6, 4%] and Pseudomonas aeruginosa [9, 6%]. Gram positive bacteria were 20 [13%], these included; 10 [7%] of each of Staphylococcus aureus and Enterococcus faecalis. Amongst strains of enterobacteria, high resistance was seen with Ampicillin [113, 93%], Amoxicillin [120, 99%], Trimethoprim [110, 91%] and Nalidixic Acid [71, 59%]. Among Pseudomonas aeruginosa strains, high resistance was seen with Ampicillin [9, 100%], Amoxicillin [9, 100%], Nalidixic Acid [7, 80%] and Nitrofurantoin [5, 60%]. Amongst strains of enterobacteria, high sensitivity was detected with Amikacin [116, 96%], Tetracyclin [67, 55%], Ciprofloxacin [81, 67%], Gentamycin [97, 100%] and Norfloxacin [108, 94%]. Among Pseudomonas aeruginosa strains, high sensitivity was seen with Amikacin [9, 100%], Ciprofloxacin [9, 100%] and Gentamycin [7, 75%]. All [10, 100%] S. aureus strains were resistant to Fusidic Acid. Among Enterococcus faecalis isolates, high resistance was seen with Ampicillin [10, 100%], Vancomycin [8, 80%] and Cefotoxime [7, 70%]. Among S. aureus strains, high sensitivity was seen with Tetracyclin [10, 100%], Gentamycin [8, 80%], Amikacin and Clindamycin [7, 70%], and Methicillin [6, 60%]. Among Enterococcus faecalis strains, high sensitivity was seen with Nitrofurantoin [10, 100%] and Amikacin [7, 70%]. Conclusion According to our findings, we conclude that antimicrobial resistance has emerged and strongly exists in Khartoum, Sudan. Resistance rate is high in aerobic Gram negative bacilli relative to Gram positive cocci. Multi-drug resistance to the easily available and locally used antibiotics is common. We, therefore, encourage clinicians to prescribe suitable alternatives. We, also encourage the health care authority to apply measures to control this problem in Sudan.

Speaker
Biography:

Suad Yousif Abdalla Alkarib has completed her PhD from University of Khartoum. She is the Founder of College of Pharmacy in Karary University. Previously, she was a Director General Manager for the “Wafrapharma Laboratories Ltd. She is the Member of the Sudanese Medical Council, and also the Member of Scientific Researches committee in Gum Arabic Board (Sudan). She is the Member of the Arab Administrative Development Organization (League of Arab States). She is the Rapporteur of the Industrial Pharmacy Committee in the Pan Arab Colleges of Pharmacy (October-2012). She is the Member of the proposed fellowship in Technology of Industrial Pharmacy (Council of pharmaceutical specialties-Sudan). She has got a Certificate of honor as a leader in the field of pharmacy, and the first female major-general (Jan-2011) Sudan. She received major awards and decorations in Competency - Duty - The national Rescue - Golden defence. She has published more than ten papers in different journals and conferences.

Abstract:

Introduction: Gum arabic is a complex, loose aggregate of sugars and hemicelluloses composed of Arabic acid nucleus connected with calcium, magnesium, potassium and sugars Arabinose, Galactose, and Rhamnose. It is found in mechanically ground or spray dried forms. The solubility varies between 2 hours in the raw gum form and 20 minutes in spray dried form. This study tended to enhance the solubility by producing an instant soluble granulated form. Methodology: The study was performed using atomized fluid bed drier. 50 kg of raw gum, subjected first to mechanical comminuting into powder, then treated with water by spraying at rate of 200 ml/min for 90 minutes. The inlet temperature was 70oC, and the outlet temperature was 40o C. Finally after water treatment process, the powder resized through Mesh size of 40 micrometer and the microbial test was done for the finished product. Results: The solubility of the granulated instant soluble gum in room temperature was found to be less than 2 minutes compared to the spray dried form which is 20 to 30 minutes and 2 hours for mechanical ground gum. The volume increased to three times compare to the mechanical form. Conclusions: Granulation of gum under water spray significantly enhances the solubility and hence it is beneficial for uses in pharmaceutical technology as a binder, suspending agent, surface active agent and tablet coating materials.

Speaker
Biography:

Amna Beshir Medani Ahmed has completed her PhD at the age of 35 years from University of Khartoum. She is the founder of Toxline .org , a new approach to connect professionals around chemical safety for the human , animal and environment safety. She has published more than 24 papers in reputed journals and conferences.

Abstract:

Cinnamaldehyde a food flavor has a high human consumption. In this study, we evaluated toxic effect of cinnamaldehyde on rats liver and kidneys. Rats were separated into 4 groups, each group containing 5 rats. The first group is control which did not receive doses of cinnamaldehyde. Second group received 500mg/kg/day (ED50), third group received 1200 mg/kg/day (TD50) and last group received 1900mg/kg/day (LD50) of cinnamaldehyde in food for period of 2 weeks. Then, sufficient amount of blood samples were collected in tube (containing lithium heparin anticoagulant), plasma was separated by centrifugation 300RBM for 3 times. Then, GOT, ALP, urea and creatinine tests were performed using Mindary BS-200 instrument. The data was collected and analyzed by variance statistical methods using SAS statistical package version (9.1) which showed a significant increase in ALP enzyme level and urea that indicated abnormalities in liver and kidney function but did not show a significant change in GOT level and creatinine. Thus the study showed that cinnamaldehyde can cause liver and kidney abnormalities and this effect is dose related, so there must be awareness and rational use of cinnamaldehyde within margin of safety and lethality as shown in the study.

  • Pharmaceutical Chemistry and Medicinal Chemistry | Green Chemistry in Pharmaceutical Industry | Pharmaceutical Microbiology and Biotechnology | Pharmaceutical Business and Market | Entrepreneurs Investment Meet
Location: Salon VI & VII, JW Marriott Dubai, UAE
Speaker

Chair

Suad Yousif Abdalla Alkarib

Karary University, Sudan

Speaker

Co-Chair

Neelima Dhingra

Panjab University, India

Speaker
Biography:

Neelima Dhingra obtained her BPharmacy, MPharmacy (Pharmaceutical Chemistry), and PhD (Pharmaceutical Chemistry) from the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. Presently, she is serving as an Assistant Professor at Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. She has 9 years of teaching and research experience. Her major area of research focuses on Designing (2D-QSAR, 3D-QSAR), synthesis, spectroscopy analysis, physicochemical parameters and biological evaluation (in vitro, in vivo, in silico) of steroidal derivatives especially 5- alpha reductase inhibitors. Her research work has been credited with 2 US patents, 4 national patents, 12 research papers in the peer reviewed journals, 7 national awards. She has presented more than 30 abstracts at various national and international conferences. She has guided MPharm candidates and presently two research scholars are enrolled with her for their PhD studies. She is on the editorial board of various national journals and is the Editor Member of Asian Council of Scientific Editors 2014 onwards. She is also life member of various national scientific bodies like APTI, IPGA, PAS, PUPS, IABMS and SPER. She is presently handling government agency like UGC, CSIR, DST funded projects worth Rs 40 lakhs.

Abstract:

This is the story of a quest spanning over hundred years to find out the novel approaches for most common and potentially progressive condition of aging men i.e. Benign Prostatic Hyperplasia. We will focus on the modern era of the both diagnostic and treatment issues available starting from the discovery of the first still besterol in the early 1937 and culminating in the discovery of the Finasteride and Dutasteride as 5α- Reductase Inhibitors in 2002. Yet one cannot be certain that the quest has ended. Past experience reveals that with the advent of profound knowledge of the pathogenesis, the natural history, risk of the progression and new generation of experiments powered by technological breakthrough, the concept of management has undergone many changes with time.

Speaker
Biography:

Swaroopa Rani N. Gupta has done Ph.D. in Chemistry from Nagpur University, Maharashtra, India in 1993. She is an Associate Professor in the Department of Chemistry, Brijlal Biyani Science College, Amravati, Maharashtra, India. She has published more than 20 papers in reputed international journals; she has presented papers at Inter National conferences at India, Singapore, London, Dubai, Hong Kong, Mauritius, Tashkent, Nepal and has been serving as Technical committee member of International Conferences at Singapore, U.K., Dubai, Hong Kong, Mauritius, Korea, Turkey, New Zealand, Nepal etc. She wants to explore world through great research interest in all aspect of world problem.

Abstract:

Bioelectrical impedance analysis (BIA) is a commonly used method for estimating body composition, and in particular body fat. Since the advent of the first commercially available devices in the mid-1980s the method has become popular owing to its ease of use, portability of the equipment and it’s relatively low cost compared to some of the other methods of body composition analysis. Present paper deals with body composition analysis of undergraduate students using bioelectrical impedance analysis method and their counseling on diet and lifestyle. Bioelectrical impedance analysis method involves determination of Body Weight, Body Fat Percentage, Segmental Subcutaneous Fat Percentage (Whole Body, Trunk, Arms and Legs), Visceral Fat percentage, Segmental Skeletal Muscle Percentage (Whole Body, Trunk, Arms and Legs), Resting Metabolism, Body Mass Index and Body Age. Results are interpreted in terms of ideal weight, overweight, underweight, Period required for weight Loss / Gain at the rate of 1.5 kg per month, Period required for wt maintenance, Fat %, Subcutaneous Fat % (Trunk), Visceral Fat %, Skeletal Muscle % (Whole body), RM, BMI, Body Age. It also highlights correct weight reduction and instructions for better health improvement and weight loss, weight gain and weight maintenance programme. For ideal weight management and for a more accurate and precise body composition analysis full Body Sensing Technology Karada Scan Body Composition Monitor – HBF-375 is used. Karada Scan measures body resistance by using weak current flowing through both hands and both feet (Bioelectrical Impedance / Biological resistance method). Tissues with more water content in human body tend to conduct electricity (such as muscle and vein) easily. Fat tissue almost conducts no electricity. The body feature is used to calculate percentage of fat tissue and non fat tissue. Current flowing through human body is very weak (50 KHz, 500A), which is not stimulant and is very safe to human body. In order to obtain body fat and other data from resistance between both hands and both feet, the five items, i.e. resistance value, height, weight, age and gender are required, which are obtained in accordance with basic human data collected by the company independently. There is little scope for technician error as such, but factors such as eating, drinking and exercising must be controlled since hydration level is an important source of error in determining the flow of the electric current to estimate body fat. The instructions for use of instruments typically recommends that measurements should not be done soon after drinking or eating or exercising, or when dehydrated. Instruments require details such as sex, age and height to be entered, and use formulae taking these into account; for example, men and women store fat differently around the abdomen and thigh region. It is important to know our biological age. If we know where the problems exist, we can initiate the lifestyle modifications necessary to improve our health and increase our vitality. Maintaining an ideal weight can help prevent obesity or weight loss and other diseases, and lead a longer life. We should build up non-fat physique by increasing skeletal muscle and improving resting metabolism. Complementing exercise along with a proper diet is the key to a healthy lifestyle. In today’s world, exercising routine is regarded imperfect without vital elements called Bodybuilding supplements. They act as a fuel for our body and boost sporting performance. Herbalife is a world leader in the wellness industry. Their products do detoxification and cleansing of body systems from the inside, weight management, supplementation, anti-aging, prevent future diseases. Among these are Aloe Plus Tablet, Afresh, Cell -U -Loss Tablet, Personalized Protein Powder, Nutritional Shake Mix, Multivitamin Mineral and Herbal Tablet, Cell Activator Tablet, Activated Fiber Tablet for better weight management. Interpretation of body composition analysis report of undergraduate students (Female + Male) shows that underweight person is 44.2 %, normal person is 45.7 %, overweight person is 7.2 % and obese person is 2.9 %; that of undergraduate students (Female) shows that underweight person is 43.4 %, normal person is 46.2 %, overweight person is 7.5 % and obese person is 2.8 %; and that of undergraduate students (Male) shows that underweight person is 46.9 %, normal person is 43.8 %, overweight person is 6.3 % and obese person is 3.1.

  • Young Researchers Forum
Location: Salon VI & VII, JW Marriott Dubai, UAE
Speaker
Biography:

Hung Lam is now studying his PhD at Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Innsbruck. He started in 2013 and has been working on thiomers and pre-activated thiomers. He has, until now, published 3 papers in reputed journals on pharmaceutical sciences.

Abstract:

The aim of this study was to synthesize pre-activated low molecular weight of poly(acrylic acid) (2-, 6-, and 15 kDa) and to investigate their enhanced mucoadhesive effects in combination with polycarbophil-cysteine conjugate (PCP-cys). PCP-cys is highly mucoadhesive owing to its free thiol groups, but its high molecular weight (approximately 3.5×109 g/mol) and its cross-linked structure may spatially hinder its interaction with mucus. Pre-activated poly(acrylic acids) are thiolated poly(acrylic acid) (PAA-cys) with their free thiol groups further conjugated with 2-mercaptonicotinic acid via disulfide bonds (PAA-cys-MNA). Pre-activated thiomers are the latest generation of mucoadhesive polymers developed by our research group and the lowest low molecular weight PAAs were chosen for this study because of their high chain mobility. The enhanced mucoadhesive effects were studied with rheological measurements of mixtures of PAA-cys-MNA and PCP-cys with purified porcine mucus. The results showed that pre-activated PAAs increased the dynamic viscosity of the mixtures of PAA-cys-MNA/PCP-cys/mucus by 3.5-, 5.6-, and 5.1-fold (respectively for PAA 2-, 6-, 15 kDa) compared to the mixtures of unmodified PAAs/PCP-cys/mucus. This finding suggests that the presence of low molecular weight and high chain mobility of pre-activated PAAs could serve as a “cross-linker” to facilitate the formation of disulfide bonds and in situ cross-linking process between PCP-cys and mucus gel and therefore increased mucoadhesion.

Speaker
Biography:

Abstract:

Malaria is the most deadly disease that concerns mostly African children under the age of five. Its treatment is difficult because of drug resistance to conventional molecules, including Artemisinin-based Combination Therapy (ACT) recommended by WHO. Several studies, for instance those of Chougouo and al. showed that the infusion of A. annua is more efficient than ACT after 7 days of treatment, but hardly accepted by children mostly those under 2 years old because of the quantity to administer. The present study is to put in place a more acceptable dosage form for children i.e. suppositories made from A. annua grown in Cameroon. To evaluate its quality, the powder of leaves and stems of A. annua has been submitted to physicochemical analysis. The particle size was determine by the sieve method and laser diffraction. Artemisinin, determined by TLC - densitometry, then read through Mesurim software. Entire flavonoids titrated by aluminum chloride. The formula of medicines established and suppositories were submitted to pharmacotechnical tests. The powder obtained, of bitter taste, greyish-green, with characteristic odor (camphor), is homogeneous with 56,37 % of particles in the sieve of diameter over or equal to 63 μm. The artemisinin and entire flavonoids contents are respectively of 5 mg/g and 0,43 mg equivalent to quercetin per gramm of dry matter. 250 mg suppositories of active principle have been made knowing that, 1g of A. annua powder moves 0,72 g of Suppocire C. They are dark-green, shiny, smooth, barrel-shaped. Their average weight is 2,15 g, disintegration time 8 min 16 s, the fusion point 35,7 ˚C. These suppositories, are in conformity with European pharmacopoeia. The suppositories will contribute to a better treatment of malaria among children

Speaker
Biography:

Mohammed Fatima is currently a graduate student in the University of Medical Sciences and Technology, Faculty of Pharmacy, Khartoum, Sudan.

Abstract:

This study was conducted to investigate the eff ect of FSH hormone and LH hormone on male fertility and its ability to cause
pregnancy in female albino rabbits using Ocimum Basilicum extract. Basil herb is one of the popular herbal plants with

This study was conducted to investigate the effect of FSH hormone and LH hormone on male fertility and its ability to cause pregnancy in female albino rabbits using Ocimum Basilicum extract. Basil herb is one of the popular herbal plants with notable health-benefiting (phytonutrients). This highly prized plant is revered as "holy herb" in many cultures all around the world and is found in Africa, Asia and America. It contain many pharmacological properties such as antibacterial, antimicrobial, antioxidant, antiproliferative, antiviral activities, cytoprotective effects, dermatologic effects, endothelial membrane fluidity effects, insecticidal effects, spermicidal effects. Ocimum basilicum contain Rosmarinic Acid (RA) with its polyphenol derived from many common herbal plants of the Lamiaceae which increase sex hormones level in blood. Using Ocimum basilicum dry leaves extract, we seek in our research to increase male sex hormones (androgens) by increasing FSH and LH and by doing so increasing fertility. New Zealand rabbits were given two different doses of the herb extract according to their weight, then blood samples were taken to laboratory for serum FSH and serum LH analysis, then statistical analysis was done. Our herb was found to be a male sexual hormone enhancer and hence a good in fertility treatment.

 

Rayan Salah Elhadi

University of Medical Sciences and Technology, Sudan

Title: Serum zinc among Sudanese with type 2 diabetes mellitus in Khartoum State
Speaker
Biography:

Rayan Salah Elhadi has completed her Bachelor’s from University of Medical Sciences and Technology, pre-master qualifying student at Institute of endemic diseases, University Of Khartoum. She is a teaching assistant of chemical pathology at Medical Sciences and Technology University.

Abstract:

Diabetes mellitus is an inherited metabolic disorder characterized by high metabolic and oxida-tive stress, and there is evidence that trace elements such as zinc and copper are important co-factors in these processes. We therefore have measured serum zinc levels in type 2 diabetic subjects from Khartoum state. 20 diabetic patients and 20 non-diabetic control subjects were included in this study. Serum zinc and random blood glucose (RBG) were measured among the study groups and the association of Zn compared with glycemic status, age, gender, and duration of diabetes. The serum zinc level was significantly higher (P-value=0.02), (2.01±0.999 ppm) in diabetic patients as compared with control subjects (1.83±0.704 ppm) respectively, There was insignificant association between study groups among the age (P-value=0.35) and gender variables (P-value=0.518). Also there was significant association with glycemic status, and duration of diabetes (P-value=0.000) with serum Zinc in the type-2 diabetic patients. We conclude that the zinc values were increased significantly, especially in diabetes mellitus with long duration of disease. Another studies show low zinc level so, further studies are recommended to address the possible role of zinc measurement and the possible impact of zinc therapy in insulin metabolism resistance states such as diabetes.

Speaker
Biography:

Eiman Adam Mohamed is a fifth year student in Faculty of Pharmacy, University of Medical Sciences and tTechnology.

Abstract:

Worldwide obesity dramatically increased to more than double since 1980. In 2014 approximately 39% of adults aged 18 years and above were either overweight or obese. 42 million children under the age of 5 were overweight or obese in 2013. In Africa Obesity rates are rapidly increasing particularly in urban settings, which considered as a major risk factor for type 2 diabetes, high blood pressure, heart attacks and a variety of cancers. As Obesity is preventable and reversible, finding a cheaper alternative anti-obesity drug will encourage obese people to reduce their weight and thereby prevent other complications. It is believed that Treatment with β adrenoreceptor agonists promotes fat loss and muscle growth. Ephedrine is a β-adrenoreceptor agonist; works as weak central nervous system stimulant. It facilitates the liberation of energy from energy stores and in turn it increases their concentration in plasma. Caffeine has many pharmacological actions including: Central nervous system stimulation, diuresis, stimulation of cardiac muscle and relaxation of smooth muscles. We are going to study the effect of a combination of the two compounds with β agonistic properties in sixteen well fed newzealand rabbits. The evaluation will be through the measurement of grams of weight lost by rabbits during one month of administration of the combination of caffeine and ephedrine and the change in lipid profile. The expected results are reduction in body weight and reduced total cholesterol level.