Isabel Torres Gomes da Silva
Universidade de Brasilia, Brazil
Title: Impact of exogenous nucleosome binding molecules on cell proliferation and gene expression
Biography
Biography: Isabel Torres Gomes da Silva
Abstract
Chromatin is a highly dynamic macromolecular complex, which shows important changes in its structure upon different cellular environment. Nucleosome binding molecules (NBM) are key modulators of chromatin structure and hence transcription and clinical outcome. Here, I will show that exogenous Nucleosome Binding Molecules – eNBMs, structure-based designed, inhibit proliferation and viability of different cancer cells lineages. Moreover, eNBMs inhibit the expression of a key gene in the inflammatory pathway, TNFalfa. Furthermore, I will discuss our integrated approach to dissect the mechanism of cholesterol action on chromatin structure. Our findings suggest that lipid molecules, such as cholesterol, may behave as physiological nucleosome binding molecules with an influential role on the chromatin structure.