Dalia Hussein Soliman
Al-Azhar University, Egypt
Title: Novel chalcone derivatives: Synthesis, QSAR studies and evaluation of their anti-prostate cancer activities and cathepsin B inhibition
Biography
Biography: Dalia Hussein Soliman
Abstract
Prostate cancer is one of the most commonly diagnosed cancers in men, and the second leading cause of cancer deaths in the European Union and United States of America. The high mortality rate is mainly attributed to the invasiveness and metastasis of advanced prostate cancer. Cathepsin B is a cysteine protease found mainly in the lysosomes. The increased expression and secretion of cathepsin B have been shown to be involved in migration and invasion of numerous human and experimental tumors. Therefore, the use of cathepsin B inhibitors reduces both tumor cell motility and invasiveness in vitro. In the present study a series of novel chalcones were prepared and studied for both their anti-prostate and cathepsin B inhibition. Furthermore, a QSAR study was carried out where models were successfully built from which the physicochemical parameters were correlated to the activity.
