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Mohamed Zakaria Gad

Mohamed Zakaria Gad

The German University in Cairo, Egypt

Title: Key Players of Nitric Oxide Production as Novel Biomarkers for Coronary Artery Disease

Biography

Biography: Mohamed Zakaria Gad

Abstract

Cardio-Vascular Disease (CVD) remains the leading cause of death worldwide. Coronary Artery Disease (CAD) represents the major CVD among several populations. Despite huge efforts and great advances in studying the genetic component of CAD, there is still a great need for exploring the genetic and environmental factors contributing in the development of this disease. Among these factors emerge modulation of Nitric Oxide (NO) homeostasis and oxidative stress as central players according to recent reports. A range of biochemical disturbances including reduced availability of NO and oxidative stress has been shown to be associated with Endothelial Dysfunction (ED). Many studies described the contribution of ED in the predisposition of CAD; in particular Myocardial Infarction (MI). Recent evidence indicates that ED may be genetically determined. This presentation points out to the key players that influence vascular NO levels and their role in the protection and/or predisposition to CAD.