Salwa Elmeligie
Cairo University, Egypt
Title: Green Chemistry as a Recent Trend in Pharmacy Education to Afford Pharmaceutical Products
Biography
Biography: Salwa Elmeligie
Abstract
Special interest in targeted cytotoxic agents is directed towards protein kinases which play several roles in cell proliferation, and targeting these proteins has been shown to be a successful strategy towards controlling different malignancies. In an attempt to develop novel antitumor agents acting through inhibiting Vascular Endothelial Growth Factor Receptor (VEGFR), a series of new aryl phthalazine derivatives has been designed and synthesized. The targeted compounds were planned and implemented into docking studies to qualitatively predict their affinity and binding modes with VEGFR-2 kinase enzyme. Docking studies were performed on the designed compounds using Accelry’s Discovery Studio 2.5 software CDOCKER protocol. The structures of the synthesized compounds were confirmed by elemental analyses and spectral data (IR, 1H NMR, 13C NMR and Mass spectroscopy). Furthermore, biological screening in the National Cancer Institute (NCI), USA is applied to test the cytotoxic activity for the prepared compounds against full NCI 60 cell panel at a single dose (10 μM). Additionally, the target compounds are evaluated for their enzymatic inhibition of VEGFR-2 kinase