Shitalkumar Patil
Ashokrao Mane College of Pharmacy, India
Title: Enhancement of solubility of poorly water soluble antihypertensive drug by solid dispersion technique
Biography
Biography: Shitalkumar Patil
Abstract
Compounds when presented in the crystalline state to the gastrointestinal tract are typically dissolution rate limited and dissolution rate is directly proportional to the solubility of compound. The compounds are typically BCS class II or class IV compounds. The rate and extent of absorption of class II compounds is highly depended on the performance of the formulated product. Solid dispersion are one of the most promising strategies to improve the oral bioavailability poorly water soluble drugs. Carvedilol is poorly water soluble (BCS class II) antihypertensive drug. The purpose of this study was to increase solubility of Carvedilol of solid dispersion (SDs) technique with poloxamer (PXM) 407 in aqueous media. The Carvedilol- PXM 407 solid dispersion system was prepared by solvent evaporation, kneading method and melting method. It was characterized by differential scanning Calorimetry (DSC),X-ray powder diffraction (XRD) analysis, Fourier transformation infra-red spectroscopy (FT-IR) and Scanning electron microscopy (SEM) and in vitro dissolution studies. The results from DSC, XRD and SEM studies shows that PXM 407 inhibits the crystallization of Carvedilol. The solid dispersion prepared in this study were found to have higher dissolution rates compared to intact Carvedilol.