Sreenivas Patro Sisinthy
Taylors University, Malaysia
Title: Development of self-nano emulsifying drug delivery systems for Olmesartan Medoxomil: a formulation by design approach
Biography
Biography: Sreenivas Patro Sisinthy
Abstract
Olmesartan Medoxomil (OLM), a BCS Class II drug, approved for use in the treatment of hypertension is a selective and competitive Angiotensin-II Receptor Blocker (ARB). The oral bioavailability of OLM in healthy humans is only 26% due to its poor water solubility. Hence, this limitation necessitates the systematic development of a suitable formulation to increase the solubility and dissolution and thereby bioavailability. Self Nano Emulsifying Drug Delivery System (SNEDDS) is a promising approach and is used in this study to increase the solubility of olmesartan medoxomil. The objective of the present study was to design, optimize and characterize SNEDDS for OLM by experimental design approach. The SNEDDS were systematically optimized using three factor Box Behnken design. Concentration of formulation variables, namely, X1 (Capryol 90), X2 (Kolliphor EL), and X3 (Transcutol P), was optimized for its impact on mean globule size (Y1), percentage drug release in 20 minutes (Y2) and turbidity (Y3) of the formulation. The prepared SNEDDS were characterized for globule size, zeta potential, dissolution studies, turbidity and Transmission Electron Microscopy (TEM). The optimized SNEDDS were found to have a globule size of 13.83 nm and a drug release of 98.31% in 20 minutes. In vitro drug release studies shown a 3-fold increase in dissolution compared to a commercial tablet. TEM studies demonstrated spherical droplet morphology. Based on the results, it was concluded that the SNEDDS is a promising drug delivery approach for the enhancement of solubility and dissolution of OLM.