Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 12th Annual
Pharma Middle East Congress Dubai, UAE.

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Day 2 :

Keynote Forum

G Raid Alany

Kingston University, UK

Keynote: How to get your work published: Editor-in-chief perspective

Time : 9:30-10:15

Pharma Middle East 2017 International Conference Keynote Speaker G Raid Alany photo
Biography:

Professor Raid Alany has over 25 years of international experience in pharmacy education, pharmaceutics and drug delivery research. His academic journey spans three continents, namely, Asia, Oceania and Europe. He received his PhD in drug delivery from the University of Otago, Dunedin New Zealand in 2001; was appointed as a Lecturer at the School of Pharmacy, The University of Auckland, Auckland, New Zealand, in 2001 where he was responsible for establishing the first pharmaceutics curriculum at The University of Auckland. He was promoted to a Senior Lecturer in 2004, appointed as Head of Pharmaceutics in 2007, promoted to Senior Lecturer above the bar in February 2009; appointed as Honorary Associate Professor in 2011. He joined Kingston University London as Professor (Chair) of Pharmaceutics in January 2011 and was appointed as Research Director for the School of Pharmacy and Chemistry in December 2013. He has been appointed as the Inaugural Head of School of Life Sciences, Pharmacy and Chemistry on 1st of June 2015. Raid won several awards such as Microscopy New Zealand Young Scientists Award in 1999 The University of Auckland's Vice Chancellor's Early Career Research Excellence Award in 2003, the Controlled Release Society Veterinary Programme co-chair/ chair Distinguished Service Awards in 2008/2009 and the Spark Ideas Challenge, Uniservices Prize and Chiasma Prize in 2011. He consults for human and veterinary pharmaceutical companies in New Zealand and Singapore and is an inventor on several international patents.

Abstract:

TBA

Pharma Middle East 2017 International Conference Keynote Speaker Heyam Saad Ali photo
Biography:

Prof. Heyam Saad Ali has completed her PhD from Bradford University, UK. She is Head of Pharmaceutics Department, Dubai Pharmacy College, UAE. She has teaching and research experience of about 25 years. She has published more than 44 papers in reputed journals and has been serving as an editorial board member of several pharmaceutical Journals. She is a member of various pharmaceutical associations. In addition to attending more than 40 training courses, conferences and seminars in Quality Assurance systems.

Abstract:

Cosmetics and personal care products are a diversity set of items commonly use in beauty health and hygiene. Despite the compelling evidence for health impacts in humans and environment of toxicity long term exposure to chemicals in these products, but still remain the excessive items consumption in the world. A growing body of hazard-based evidence suggests connections to long-term health concerns like cancer and reproductive problems. Advertising in the fashion and beauty and the industry misleading claims has effect on women.This presentation will focus on:

  1.   The cosmetic industry’s influence on women.
  2.   Legal standards for Misleading claims and regulatory bodies.
  3.   Harmful effects of using cosmetics.
  4.   List of safest chemicals.
  5.   List of concern.
  6.   Reduction of health environmental impacts of cosmetics. 
  7.  Steps to be taken to reduce toxic exposures & safer alternatives.

  • Sessions:
    Pharmacognosy and Phytochemistry | Nanotechnology | Pharmaceutical Chemistry and Medicinal Chemistry | Green Chemistry in Pharmaceutical Industry | Pharmaceutical Microbiology and Biotechnology | Pharmacological sciences | Biopharmaceutical sciences
Speaker
Biography:

Sahar S Abd El-Rahman is currently a Professor of Pathology, Faculty of Veterinary medicine, Cairo University, Egypt. Dr. Sahar is an active Member in Egyptian Veterinary Medical Society of Pathology and Clinical pathology (EVMS) and Egyptian Veterinary Medical Association (EVMA). She has attended several continued education and technical workshops since, 1993. In addition, she has attended a number of workshops on Quality assurance and Development of Faculty Members. She has joined a number of scientific conferences since 2002, in some of them she was a member of the Organizing Committee. Dr. Sahar has shared in the supervision as well as in the arbitration of a number of master and doctoral theses. She has published about 34 scientific papers, 18 of which were published in international journals. She is a reviewer in a number of international journals and a member of the editorial board in other international journals.

Abstract:

Introduction: AflatoxinB1 (AFB1) is well-known as a feed borne-immunosuppressive mycotoxin. Nanotechnology is a powerful new technology for reconstructing nature at the atomic and molecular level. This study was conducted to determine the efficacy of nano-composite magnesium oxide and silicon oxide (MgO-SiO2) to reduce the toxic effects of AFB1on the immunity of adult male rats for 8 weeks. Experimental design: Animals were divided into a control (Gp1) and three experimental groups (Gps); Gp2 received feed contained 0.5g/kg nano-composite MgO-SiO2, Gp3 received feed contained 200ppb/kg AFB1. While rats of Gp4 received feed contained 200ppbAFB1/kg and 0.5g/kg the nano-composite. Methods: Cellular and humoral immune responses, as well as histopathological examination and caspase-3 expression in liver, spleen, and GIT were all evaluated. Residual concentration of AFB1was determined in serum, liver and fecal samples. The obtained data were statistically analyzed. Results: AFB1markedly reduced body weight gain and food and water consumption. Both cellular immune response (total and differential leukocytic count, neutrophils’ phagocytic activity, lymphocyte transformation, macrophage activity and serum lysozyme activity) and humoral immune response (serum total protein and its fractions as estimated by SDS- PAGE electrophoresis) were severely reduced byAFB1. Moreover, AFB1induced marked histological alterations and apoptosis in liver, spleen, and GIT. The addition of nano-composite MgO-SiO2 to feed containing AFB1could markedly alleviated the deleterious effects ofAFB1. Conclusion: These findings suggested that nano-composite MgO-SiO2 has high affinity to adsorb AFB1and can effectively modulate its toxicity in rats. Impact statement: Nano-composite MgO-SiO2 may offer a novel approach for the preventive management of aflatoxicosis in animals

Biography:

Abstract:

It was planned to synthesize dual-responsive hydrogels from N-isopropyl acrylamide (NiPAAm), acrylic acid (AA) and methacrylate (MA). Hydrogels were prepared by free radical copolymerization using ethyl alcohol as a solvent, a redox initiator, benzoylperoxide (BPO) and ethylene glycol dimethacrylate (EGDMA) and diethylene glycol dimethacrylate (DEGDMA) as cross-linkers. The network parameters like polymer mesh size (ξ) (23.78 to 820 Å), molecular weight between the cross-links (Mc) (970-356096 gmol-1) and crosslink density (q), (0.0928 to 0.00025) were calculated at various pH using the Flory-Rehner Theory. Hydrogels exhibited the non-Fickian diffusion mechanism. FTIR spectral analysis and (TGA/DSC) were carried out to characterize the systems and new LCST was found to be increased. Tramadol HCl was used as the model drug to investigate the drug loading and unloading behavior of these gels. It was concluded that these systems exhibited a sharp change in their media sorption capacity and mesh size of the networks with the change in the pH and temperature of the swelling media, proposing their strong candidature for being used as oral drug delivery systems. The results favored the idea to apply these hydrogels to use as targeted drug delivery systems for the proximal part of the gastro-intestinal tract.

Speaker
Biography:

Ms. Mansi Paradkar has completed her M.Pharm (Pharmaceutics) at the age of 24 years from Sardar Patel University. She is currently associated with Department of Pharmaceutics and Pharmaceutical Technology of Ramanbhai Patel college of Pharmacy, CHARUSAT University as an Assistant Professor since 5 years. Her accomplishments in the current organization include supervising nine pharmaceutics projects of Master of Pharmacy students in the area of cerebral malaria, colon cancer, fungal infection, rheumatoid arthritis, emesis by formulating various drug delivery systems including application of nanotechnology. Her research publications are in the journal of 'Drug development and Industrial pharmacy' and 'Saudi Pharmaceutical journal'. One of her research work has been filed for Indian patent.

Abstract:

Artemether (ARM) microemulsion (ME) for intranasal delivery was developed using Isopropyl Myristate (IPM) as oil, Cremophor EL as surfactant and propylene carbonate as co-surfactant by water titration method. The optimized batch ME1 was evaluated by globule size, zeta potential, viscosity, TEM and solubilization capacity.  %In vitro Drug release using modified Franz diffusion cell and histopathological studies from ME1 was carried out through sheep nasal mucosa. Comparative in vivo anti-malarial performance of the developed ME1 was evaluated against the ARM solution and marketed oral ARM formulation (Larither®) Plasmodium berghei infected mice as per Peter’s four day protocol. The parameters studied were %parasitemia, activity against time and animal survival period. TEM micrographs indicated that ME1 had a nearly monodispersed spherical shape with size ranging about 30nm. The mean viscosity of about 106.7cP suggested increased residence time and -18.43±0.86 Zeta potential indicated stability. Significant improvement in drug solubility overcome dissolution rate-limited absorption of ARM and this was realized with higher permeation coefficient during ex-vivo drug release studies. Histological examination of formulations did not show any remarkable damage to nasal mucosa. The animals treated with ME1 exhibited highest reduction in the percent parasitemia and 4 fold higher antimalarial activity with reduced mortality rate as compared to all other groups (P < 0.05). This demonstrates the utility of the microemulsion approach in improving the delivery and therapeutic efficacy of ARM through intranasal administration for the treatment of malaria.

Biography:

Dr. Grandhi Surendra has completer PhD from Andhra University in pharmaceutical chemistry Department. He has acquired 9 years of reserach experience and published more than 15 national and international journals, he has also presented a paper at 2nd ICIP 2016, Malyasia

Abstract:

Objectives: The aim of the present study was to estimate flavonoid and phenolic content, and to evaluate invitro antioxidant activity of an aqueous extract of Alpinia nigra and Allium tuberosum.
Methods: The air dried stem of A. nigra and leaves of A. tuberosum was ground to powder and extracted with water and 95% of ethanol. The extract was screened for phytochemicals, total phenolic content (TPC) and total flavonoid content (TFC) with its potential antioxidant activities using hydrogen peroxide-scavenging assay.
Results: Phytochemical test shows that extract contains variety of phytochemicals among which there is a high level of total phenol and flavonoids. The total phenolic content (TPC) of A. nigra and A. tuberosum was 0.450±0.0740 and 1.663±0.296; respectively. The total flavonoid content (TFC) of A. nigra and A. tuberosum was 0.322±0.077 and 0.978±0.119, respectively. The plants possessed potent antioxidant activity when compared with the reference compound ascorbic acid (vitamin C).
Conclusions: A. nigra and A. tuberosum may be useful for the preparation of neutraceuticals as potent antioxidant to treat various human diseases and their complications.

Biography:

Ms. Jagruti Prajapati has completed her M.Pharm from Maharaja Sayaji Rao Unmiversity of Baroda, Vadodara and pursuing Ph.D. and working as Assistant Professor at the age of 27 years from Ramanbhai Patel College of Pharmacy, CHARUSAT, Changa. She has published 5 papers in reputed journals and writing two book chapters in reputed publication

Abstract:

“Agomelatine” is melatonin receptor (MT1 & MT2) agonist and 5HT2c antagonist, widely used for major depressive episode, absolute bioavailability is <5%. The aim of present study is to develop Agomelatine microemulsion for intranasal delivery, to improve bioavailability. Preformulation study (Purity& Compatibility) was established by Melting point, λmax by UV–Visible spectrophotometry, FTIR, XRD, DSC. Solubility study of drug was conducted in various oils, non-ionic surfactants and co-surfactants. Ternary phase diagrams were constructed to evaluate the microemulsion regions for 1:1, 1:2, 1:3, 2:1, 3:1 of Smix (Chemix). A single isotropic region was found in pseudo-ternary phase diagrams. Microemulsion was formulated by water titration method. Smixratio 1:1 was selected based on ternary phase diagram and conductivity measurement. In preliminary study, the concentration of oil and Smix were optimized on the bases of globule size. Reported dose of drug is successfully loaded in 0.1ml of ME prepared using optimized oil and Smix concentration range. Microemulsion of Agomelatine was optimized by mixture design of experiment. Prepared microemulsion was characterized by globule size (15 nm), viscosity (80 cps), zeta potential (-47mv) and TEM, Confocal Microscopy Study. In vitro drug release study of pure drug and Agomelatine Microemulsion was performed, in which Agomelatine microemulsion shows 100% Cumulative Drug Release which follows higuchi model. In vivo study (Pharmacokinetic and Pharmacodynamic) was also performed. Pharmacodynamic study was done by Forced Swim test. Pharmacokinetic study revealed that Bioavailability of Agomelatine Microemulsion was increased. Stability study of the same was also performed for heating-cooling cycle, freezw-thaw cycle and centrifugation.

Speaker
Biography:

Rashid Mahmood has Master Degree in Analytical Chemistry and MS in Total Quality Management. He has 13 years of experience of Pharmaceutical Quality Operations and has attended many international conferences as a keynote speaker. He has presented various talks in USA & China on Cleaning Validation, cGMP Guidelines and Quality Risk Management. Currently he is working as a Senior Executive Manager Quality Operations for Surge Labs(Manufacturer of Microencapsulated APIs, Liquid & Dry Powder Parentrals) which is the best export oriented company in Pakistan.

Abstract:

Green Chemistry is the new scientific “philosophy” that strives to promote sustainable development through science and technology and achieve the goals of environmental protection, health and safety of employees and consumers by producing non toxic products. Green Chemistry provides 12 Principles as a
framework for scientists to promote the designing of new processes and materials, new energy sources, alternative methodologies and renewable sources for the manufacturing industries. In a world with a continuously increasing population and limited resources the idea of a sustainable development is of major importance for the future in the 21st century.
Only research and innovation will allow the development of economic and social networks and processes that fulfill the requirements of sustainability. The future has to be planned with visions, creativity and fantasy, including
really new approaches and the exploration of the unknown. Sustainability in science and technology begins when we start thinking how to solve a problem or how to turn science into technology. Only chemical processes,
which have reached – after careful optimization – a maximum in efficiency, will lead to more sustainable products. Scientists and engineers, who invent, develop and optimize such processes, therefore play a key role. Their awareness, creativity and looking ahead is needed to bring reactions and chemical processes to maximum efficiency. The term "Green Chemistry" has been coined for efforts towards this goal. Green chemistry is a science-based non-regulatory and economically driven approach to achieving the goals of environmental protection and sustainable development. Consumers and business purchasing departments can promote green chemistry by demanding safer, non-toxic products from manufacturers. Green economic innovation for the 21st Century will require green chemistry.

Speaker
Biography:

Mohamed Mahmoud Elseweidy is a professor of  clinical Biochemistry and clinical nutrition  since 1991 at Zagazig University, Egypt. He is also a member of Permanent Scientific Committee (supreme Council of universities, EGYPT) For professors and Assistant professors positions (Biochemistry). His research interests include diabetic complications and hyperlipidemia, natural antioxidants and their applications in hyperlipidemia and diabetic nephropathy gastritis , role of Helicobacter pylori and natural products as therapeutic agents. He is a member of  American Association for clinical chemistry, American Society for clinical Pathology ( ASCP), Egyptian Soc for clinical chemistry, Egyptian  soc For Pharmaceutical Sciences, Clinical Laboratory Scientist (CLS/ chemistry).

Abstract:

Insulin-degrading enzyme (IDE, insulysin) is a rate–limiting enzyme in the insulin degradation process. It is an intracellular 110-kDa thiol zinc-metalloendopeptidase located in the cytosol, peroxisomes, endosomes and cell surface. IDE catalyzes degradation of several small proteins including insulin, amylin and β-amyloid protein. In addition, insulin clearance was expressed as a target in the treatment of type 2 diabetes given the role of hyperinsulinemia in the pathogenesis of insulin resistance. In this study, fourtyadult male Wistar albino rats were used, thirty rats received 20% fructose in drinking water (HFW) for six weeks to induce diabetes. Subsequently, these rats developed significantly higher body weights, dyslipidemia, hyperglycemia and insulin resistance compared to their controls. Significant increase in the levels of serum glucagon, IDE in liver tissue along with an inhibition of insulin receptor phosphorylation were also observed. Concurrent oral administration of vitamin D3 along with HFW resulted in significant decrease of serum glucose, total cholesterol, triacylglycerol and LDL-C levels. Vitamin D alleviated also insulin resistance, where both IDE, glucagon levels showed significant decrease along with activation of insulin receptor phosphorylation. Normal rats, received vitamin D3 only demonstrated non significant changes of the studied biomarkers. We concluded that vitamin D3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received HFW through reduction of IDE and activation of insulin receptor phosphorylation.

Speaker
Biography:

Dr. Abdullatif Ali Azab was born (1960) in Ara, a famous historical location in Wadi Ara. He completed all his degrees in the Hebrew University of Jerusalem (PhD in medicinal chemistry). After a long career (35 years) in chemical education (high schools and colleges), along with chemical industry (chemical hazardous waste treatment, 6 years), he moved to research of medicinal plant, actually returning to his family traditions, where many of his ancestors were traditional healers. Galilee Society, he is strating now his own Eastern-Plants-Company, which will produce plants based cosmetic and food producs. It will also include research (young Arab researchers) and educational (mainly for high school) divisions. In the mean time, his research continues in the Triangle Research & Development Center (TRDC) of Al-Zahrawi Society (http://www.trd-center.org). Dr. Azab has scientific collaborations with well known scholars in Israel and seeking more with the international scientific community, especially in the middle eastern region and the Mediterranean countries. Dr. Azab has significant skills in organic synthesis, spectroscopy (especially NMR and GCMS) and vast knowledge of his homeland plants. In 2013 while performing his post doctoral research in the radiology (MRI) department of Hadassah Medicla center of the Hebrew University, he was awarded the Teva (drug company) neuroscience award for an outstanding synthesis protocol of a psychoactive compound. Dr. Azab is married to Nawal (Arabic language teacher) and the raise their three sons, Ali, Hosam and Mohammad.

Abstract:

Plants are by humans used for medicinal purposes since the dawn of humanity. Among these, plants with anti-inflammatory activity are well known to most cultures, especially the Palestinian traditional medicine which is known for its vastness. However, this ethnomedicine used many plants of different genera to treat inflammations. The methods of herbal treatment were documented or passed verbally through generations. Among these plants, there are well known to other cultures such as Malva sylvestris, Micromeria fruticosa and Salvia officinalis. Expectedly, modern, published research approves this traditional knowledge (Benso, B. et al, 2016; Abu Gharbieh, E. et al., 2013 and Baricevic, D. et al, 2001, respectively). But these are aromatic plants, with very pleasant odors, that are expected to have medicinal activies. Carob (Ceratonia siliqua) is a very well known tree for Palestinian culture, and its very impotrant nutritional resource. Its anti-inflammatory capacities were known and used for centuries, especially against mouth and throat inflammations. But strangely and interestingly enough, the anti-inflammatory of this proven activity was studied just in the last few years (Lachkar, N., et al., 2016; Rtibi, R., et al., 2016). Our current research focuses of other plants that are known to Palestinian ethnomedicine for having anti-inflammatory and other medicinal activities. Currently, we have studied three plants and the results indicate that at least one of them has proven anti-inflammatory activity. Our list includes other 16 plants that were reported to us by local Palestinian people as having such activity. These plants have three common properties: 1) Their anti-inflammatoty potential was never studied and published before. 2) The chemical compositions of all of them are either partially or completely unkown. 3) All of them are known to Palestinian ethnomedicine as having medicinal potential. We will present some plants that Palastenian ethnomedicine use to treat inflammations, published, being studied and with future research plants.

Speaker
Biography:

Nasrin Ghassemi Barghi was born in Ardabil (Iran) at 1989. She is a PhD candidate of toxicology at Mazandaran University of medical sciences. She accomplished her M.s in toxicology from Isfahan University and BS of laboratory sciences from Kerman University of medical sciences. Scientifically, she has been interested in genotoxicity and comet assay and erythropoietin tissue protective effects. she is also interested in cancer chemotherapy and secondary malignancy induced by anticancer drugs. She works on antioxidants such as melatonin and EPO and … She has outstanding records of scientific and academic accomplishments with multiple research, publications in highly prestigious journals and various presentations in both national and international conferences.
Research interests: Cell culture; Apoptosis; Nanotoxicology; Synthsis of Chitosan nanoparticle; Western blotting; Genotoxicity; Comet and Micronucleus assay; HPLC, in vivo Organ Toxicity.

Abstract:

Mitoxantrone is an anti-neoplastic anthracenedione derivative that inhibits DNA replication and induces single and double strand breaks by intercalating in DNA through hydrogen bonding. Mitoxantrone is used in the treatment of certain types of cancer such as acute myeloid leukemia and is one of the few drugs approved for the treatment of progressive multiple sclerosis (MS).As a Topoisomerase II (TOP2) inhibitors ,mitoxantrone cause DNA damage in normal cells through apoptosis, mitochondrial dysfunction, free radical generation and lipid peroxidation. Erythropoietin (EPO) is an essential glycoprotein that facilitates red blood cell maturation from erythroid progenitors and mediates erythropoiesis. The use of recombinant human EPO (rHu-EPO) dramatically changed management of anemic patients with chronic kidney disease and improved their quality of life. Besides, recent research’s showed that (EPO) was a major component of tissue-protective system. EPO prevents apoptosis, reactive oxygen species generation and lipid peroxidation process. But the long-term or frequent administration of rHu-EPO due to its short half-life and high doses associated with adverse side effects such arterial hypertension, cerebral convulsion/hypertensive encephalopathy; thrombo-embolism,iron deficiency and influenza-like syndrome. One of the major reasons for the growing interest in nano-drug delivery systems is the potential to generate targeted delivery, decreased in doses and triggered release of drugs to specific cells and tissues. Therefor in this study we report first, the production and characterization of nanoparticles using the ionotropic gelation method between the biopolymer chitosan (CS) and tripolyphosphate (TPP) ion with simultaneous encapsulation of the glycoprotein rHu-EPO and subsequently explore the effect of CS-TPP-EPO nanoparticles in mitoxantrone-induced genotoxicity. For this purpose cells were incubated with regular rHu-EPO and rHu-EPO loading (CS-TPP) nanoparticle and mitoxantrone in pre and co-treatment condition. Our results showed that both regular rHu-EPO and rHu-EPO loading chitosan tripolyphosphate nanoparticles reduced the effects of mitoxantrone significantly by reduction of the level of DNA damage measured with the comet assay.

Speaker
Biography:

Prakash Kinthada is a Professor in Chemistry at Sri Vidyanikethan Engineering college, JNTU University in Ananthapur, A. Rangam Peta, Tirupathi, India.

Abstract:

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc. My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds   that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry ,  especially    Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron,  Nickel, Zinc, Cadmium etc.

The main emphasis of my talk would be on Different class of Ligands, their Schiff’s Bases and Transition Metal Complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as Anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing Binding sites and diverse strategies employed by my group for elucidation of Anti-Cancer and Anti-HIV drug Leads to Circumvent the problem caused by Cis-Platin. We have synthesized and characterized several phytochemicals from Traditional Medicinal Plants and isolated some phytochemicals and  made the corresponding Oximes, Thiosemicarbazones and Substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their Transition Metal Complexes especially with Gold, Platinum, Palladium, Ruthenium, Copper etc. and Studied their Anticancer Activity, Nuclease activity etc. and tested their potential as Anticancer Drugs. The main aim of our extensive/preclinical Pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavanoids etc., which have very interesting structural features and properties and hence are excellent candidates as Anti-Cancer and Anti-HIV drugs .The main aim of our research is Design ,Development and Synthesis of Transition Metal Complexes/ Organometallic Compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance Cancer Killing with less toxic effects and would certainly lead to initiation of clinical trials.

Biography:

Dr. Khan’s interests include translation of epidemiological information to national, regional and global disease control policy. His work has focused on generating scientific evidence through basic research, facilitate surveillance networks and promote the use of vaccine to control infectious disease by conducting vaccination demonstration project. His research and work has been regularly published in scientific journals since 2004.

Abstract:

Typhoid vaccines have been available as a means of disease control and prevention since 1896; however, their use as a routine tool for disease prevention in endemic settings has been hampered because of: 1) insufficient data on disease burden particularly regarding the lack of health care access in the poorest communities affected by typhoid; 2) limitations of the typhoid vaccine, such as shorter duration of protection, moderate efficacy in young children, and no efficacy for infants; 3) inadequate evidence on potential economic benefits when used at scale; 4) neglect in favor of alternative interventions that require massive infrastructure; 5) no financial support or commitment regarding vaccine delivery cost; 6) ambivalence about whether to invest in water and sanitation hygiene versus the vaccine; and 7) clarity on global policy for country adoption. The World Health Organization (WHO) in 2008 recommended the use of currently licensed typhoid vaccines using a high risk or targeted approach. The epidemiology of disease and the vaccine characteristics make school-based vaccination most feasible in reducing typhoid disease burden in many settings. To assess feasibility of school-based typhoid vaccination, two districts in Kathmandu, Nepal and two towns in Karachi, Pakistan were selected for pilot program.. In total 257,015 dosesof Vi polysaccharide vaccine were given to students in grades 1–10 of participating schools. The vaccination coverage ranged from 39 percent (38,389/99,503) in Gulshan town in Karachi, to 81 percent (62,615/77,341) in in Kathmandu valley. No serious adverse event was reported post vaccination. The coverage increased in the second phase in Pakistan and Nepal. There was an initial concern of vaccine safety. However, as the campaign progressed, parents were more comfortable with vaccinating their children in schools. Supported and conducted by departments of health in Pakistan and Nepal, a school-based typhoid vaccination was found to be safe and feasible.