Medani A B
Nile College of Pharmacy, Sudan
Title: Evaluation of the toxic effect of cinnamaldehyde food flavor on the liver and kidneys of rats
Biography
Biography: Medani A B
Abstract
Cinnamaldehyde a food flavor has a high human consumption. In this study, we evaluated toxic effect of cinnamaldehyde on rats liver and kidneys. Rats were separated into 4 groups, each group containing 5 rats. The first group is control which did not receive doses of cinnamaldehyde. Second group received 500mg/kg/day (ED50), third group received 1200 mg/kg/day (TD50) and last group received 1900mg/kg/day (LD50) of cinnamaldehyde in food for period of 2 weeks. Then, sufficient amount of blood samples were collected in tube (containing lithium heparin anticoagulant), plasma was separated by centrifugation 300RBM for 3 times. Then, GOT, ALP, urea and creatinine tests were performed using Mindary BS-200 instrument. The data was collected and analyzed by variance statistical methods using SAS statistical package version (9.1) which showed a significant increase in ALP enzyme level and urea that indicated abnormalities in liver and kidney function but did not show a significant change in GOT level and creatinine. Thus the study showed that cinnamaldehyde can cause liver and kidney abnormalities and this effect is dose related, so there must be awareness and rational use of cinnamaldehyde within margin of safety and lethality as shown in the study.
