Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 12th Annual
Pharma Middle East Congress Dubai, UAE.

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Day 1 :

Pharma Middle East 2017 International Conference Keynote Speaker  Raid G Alany photo
Biography:

Professor Raid Alany is a registered New Zealand Pharmacist with a PhD from the University of Otago, Dunedin, New Zealand. He is the Inaugural Head of School of Life Sciences, Pharmacy and Chemistry at Kingston University London, UK; holds an honorary professorship at the University of Auckland, New Zealand. He is the Editor-in-Chief of Pharmaceutical Development and Technology (Taylor and Francis) and Immediate Past President of the New Zealand Chapter of the Controlled Release Society. Raid’s research is on ophthalmic drug delivery, lipid and surfactant-based systems, in-situ gels and animal health. He holds international patents that have been commercialized in New Zealand and Australia where he consults for animal health companies, regulatory bodies and IP-specialized law firms. His research gate score is 35.72 and his h-index is 21 (google scholar).

Abstract:

Currently, there are 26 UK-based universities that offer the Master of Pharmacy (MPharm) degree which is one of the main requirements to practice pharmacy in the UK. To register as a pharmacist in the UK, one must successfully complete a GPhC accredited (MPharm) course, which is a full-time, four-year course followed by successful completion of one year's pre-registration training, a period of paid employment in a community or hospital pharmacy during which a trainee is required to build up a portfolio of evidence and demonstrate their competence whilst being observed at work. This is followed by successful completion of the GPhC's registration exam along with meeting the fitness to practice requirements for registration as a pharmacist. On the other hand; courses in pharmaceutical sciences (BSc and MSc) throughout the UK are aimed at training graduates and preparing them to work in the pharmaceutical industry or specialize in regulatory affairs or clinical trials.

Universities in the UK are reaching out to universities around the world to establish partnerships for joint provision. Such partnerships could come in various shapes and forms. The QAA UK Quality Code defines collaborative provision as ‘learning opportunities leading or contributing to the award of academic credit or a qualification that are delivered, assessed or supported through an arrangement with one or more organizations other than the degree-awarding body’. Validation, franchise, dual degree, double degree, joint degree, articulation and placements are terms that are used in this context and could be rather confusing.

This key note will cover the key aspects of pharmacy / pharmaceutical sciences education in the UK. This will be followed by an explanation of the various forms of joint academic provision that are already in place and are available to pursue by universities in the Middle East should they wish to partner with a UK-based university.

Keynote Forum

Heyam Saad Ali

Dubai Pharmacy College, UAE

Keynote: Nanotechnology

Time : 10:15-11:00

Pharma Middle East 2017 International Conference Keynote Speaker Heyam Saad Ali photo
Biography:

Prof. Heyam Saad Ali has completed her PhD from Bradford University, UK. She is working as a head of pharmaceutics department, head of quality assurance and auditing  unit  of Dubai Pharmacy college, UAE,  since 2000.She has teaching and research experience of about 25 years. She is a member of various pharmaceutical associations. She contributed more than 50 articles to reputed international scientific journals in different controlled and targeted drug delivery systems.  She has been invited as speaker to numerous International conferences .She is reviewer and member of editorial board of many international pharmaceutical journals.

Abstract:

Nanotechnology is the study of extremely small structures. It can be used for a broad range of applications and the creation of various types of nano materials, nano devices, and nano- systems, due to their unique properties. This presentation will include: different manufacturing approaches, aspects and scope of nanotechnology. The advancement of nanotechnology and its applications to in the field of medicines and pharmaceuticals in different areas has revolutionized the twentieth century.  Pharmaceutical Applications of nano particles in drug delivery and protein and peptide delivery, has impact in drug development, bioavailability, stability.  Clinical Applications of nanotechnology in various nano systems in cancer therapy such as carbon nano tube, dendrimers, nano crystal, nano wire, nano shells etc and in operative dentistry, ophthalmology, surgery, visualization, tissue engineering, antibiotic resistance, immune response and  the treatment of neuro degenerative disorders, tuberculosis, and Parkinson’s disease and Alzheimer’s disease.

  • Sessions:
    Clinical Pharmacy and Pharmacotherapeutics | Industrial Pharmacy and Pharmacy Practice | Drugs and Regulations

Session Introduction

Sawsan Abuhamdah

Al Ain University of Science and Technology, UAE

Title: Melissa officinalis L. essential oil as potential treatment for agitation in people with severe dementia
Speaker
Biography:

Dr. Sawsan Abuhamdah is a Jordanian registered Pharmacist, has completed her PhD from Durham University, UK and postdoctoral studies from Granada Medical School, Department of Pharmacology, Spain and has won postdoctoral Fulbright Research Award at the University of Toledo, Department of pharmacology and experimental therapeutics, Ohio, USA, 2014-2015. Promoted to associate professor in 2014 at the faculty of pharmacy, University of Jordan and now acting as deputy dean, College of Pharmacy, Al Ain University of Science and technology, Abu Dhabi, UAE. Dr. Abuhamdah has published many original research articles in peer-reviewed journals and participated in the preparation of many symposium abstracts. Dr. Abuhamdah is a member of the British Pharmacological Society (BPS), British Neuroscience Association (BNA), Sigma Phi Sigma Pharmaceutical Sciences Honor Society, University of Toledo, USA, Jordan Pharmaceutical Association and has been serving as an editorial board member of reputable pharmaceutical journals.

Abstract:

Agitation is a common clinical challenge; it often precedes the diagnosis of common age-related disorders of cognition such as Alzheimer's disease. More than 80 percentages of people who develop Alzheimer's eventually become agitated or aggressive. Agitation also accompanies dementia, it has been estimated that agitated behaviour occurs in 70-90 percentage of the patients with dementia at some point during their illness. An ideal agent for the acute treatment of agitated patients should be easy to administer and not traumatic; provide tranquilization without excessive sedation; have a rapid onset of action and have low risk for significant adverse reactions and drug interactions. Currently available pharmacologic treatments for agitation do not fulfil all of these criteria; there are significant unmet needs for novel anti-agitation treatments. Several plant species are used for their effect on symptoms such as anxiety, restlessness, and excitability these include Melissa officinalis, commonly known as lemon balm a member of the mint family, has been considered for many centuries as a "calming" herb. It was used as far back as the middle ages to reduce stress and anxiety and promote sleep. In order to elucidate the pharmacological basis for Melissa actions, a pharmacological screen has been conducted using radioligand binding focusing on a range of ligand-gated ion channels, in rat cortical membranes. Melissa oils were sourced from four separate authenticated suppliers. Interactions of the oils with both G-protein coupled receptors (5-HT1A, 5-HT2A, muscarinic M1 and histamine H3) and ligand-gated ion channel receptors (NMDA, nicotinic and GABAA channel, agonist and benzodiazepine sites) implicated in agitation in severe dementia have been examined.

Speaker
Biography:

Bayan Darwesh has completed his pharm D from King Abdulaziz  University in Jeddah. She is  director of Pharmacy Department in King Abdulaziz University Hospital in Jeddah. 
She is responsible to Initiate Pharmacy Automation projects to streamline and modernize the daily routine workflow in line with international standards. 

Abstract:

The use of automated dispensing systems has been lauded for improving patient safety within the processes of healthcare. Adverse drug events, for example, are a common manifestation of faults in the service delivery of a pharmacy department that endanger patient safety. Even though automation may reduce the occurrence of such errors, concerns have been raised about the efficiency and safety of the automated systems since a large number of patients still suffer medication associated injuries. Though the use of these systems is common in some developed countries, there is paucity of safety and efficacy data from the Arab nations. We therefore report our experience using automated dispensing systems in all our units at the KAUH following a successful pilot run of this technology. 
 
Materials and methods: We installed the automated dispensing system and monitored the number of controlled and uncontrolled medications used before and after the automation, the incidence of wrong bin opening and the number of IV medication preparations after the installation of the system.
 
Results: The number of controlled and uncontrolled medications dispensed in KAUH generally reduced. The decrease in the number of uncontrolled medication was statistically significant, p value 0.004. We also observed an increase in the number of IV medication preparations consequent to reduced workload and improvement in staff utilization. After installation of the automated dispensing system there was a high incidence of wrong bin opening, which reduced gradually after the first two months.

Speaker
Biography:

Saeed Albaraki completed his PhD from University of Leeds, UK in 2011 in industrial pharmacy and pharmaceutical engineering.  Dr. Albaraki is the Deputy Director of the Scientific Research Centre of the Medical Services of the Armed Forces, KSA. He has published his research work on pharmaceutical formulation, manufacturing, plasma fractionation and pharmaceutical engineering in reputed journals and has also presented his work in national and international scientific conferences and meetings.

Abstract:

Technically, human plasma for fractionation may be obtained by separation of plasma from whole blood (recovered plasma) or by apheresis (source plasma). The use of Apheresis technique is very helpful in the recovery of plasma and yields almost four times more than other techniques. The bulk of the plasma collected for fractionation is provided by paid donors. For example, USA plasma derived yield from whole blood amounted to 3.5 million litres, while 12 million litres was obtained via plasmapheresis. As with other pharmaceutical industries, PDM fractionation investment is based on four aspects, Knowhow, market, high capital and raw material (Plasma). The main obstacle to start local plasma fractionation is the maintenance of a regular, adequate and safe source of supply of around 300K litres of   plasma. In case of shortage of plasma supplies, the alternative project such as self-sufficiency program (SSP) need to be implemented. Finland, Malaysia, Norway and Singapore are good example of self-sufficiency fractionation toll of local plasma. SSP based on local collection of plasma (around 30k-50k litres ) and shifting fractionation through special contracts with international fractionators. Consumption of PDM products such coagulation factors FVIII and FIX, albumin and immunoglobulins (IVIG) shows around 10% annual increment. The recent applications of IVIG in  Alzheimer’s disease  and some other  neurological disorders has created a profound interest and use of PDM products. Unlike pharmaceutical industry, around 40% of the final price for the manufacturing of PDM  goes to raw materials and not to marketing. Collection of local plasma for fractionation will dramatically reduce the final prices of the products. In addition, building up a national  collection program of plasma will increase the local strategic stock for any crisis. The fractionated yield of coagulation factors produced by Self-sufficiency fractionation program is very high and will greatly  help to start a prophylaxis program for haemophilic patients. Local fractionation or SSP will also help in the creation of the much needed  local employment opportunities and support the local economy. SSP will also  help to secure a reglar , uninterrupted  and safe supply for the patients receiving PDM . A better quality control can also be implemented to strenghten the safety standards of the final products and the influence of any possible gene therapy will be excluded.

Tuba Aydin

Agri Ibrahim Cecen University, Turkey

Title: Effects of Herniarin on sepsis induced rats’ liver
Speaker
Biography:

Tuba Aydin is currently working as an assistant professor in the Faculty of Pharmacy at the Agri Ibrahim Cecen University, Turkey where she has been a faculty member since 2013. She completed her PhD at Ataturk University, Turkey. She has expertise in isolation and characterization of phytochemicals from natural products.

Abstract:

TBA

Biography:

Abstract:

Background and Objectives: Rheumatoid Arthritis patient’s adherence to pharmacologic therapy is important to achieve therapeutic goals and improve outcomes. Our study objectives are to explore the adherence level, disability index and pain score in patients with rheumatoid arthritis and to understand the relationship between certain patient variables with adherence and Disability. Design and settings: A cross-sectional study with a self-administered questionnaire to RA patients. Participants gave their consent and were recruited from outpatient pharmacy waiting areas in different tertiary hospitals in Riyadh, the capital city of Saudi Arabia. Patients and Methods: This study Included (126) adults with Rheumatoid Arthritis. A self-administered questionnaire to RA patients using a special tool that collect demographic and clinical information, adherence and outcome assessment. 4 pages survey that contains three sections: (1) demographic and clinical data, (2) Adherence measured using 8-item Morisky Medication Adherence Scale (MMAS-8) by using validated Arabic version to assess patient's adherence, (3) Health Assessment Questionnaire (HAQ) to assess patient's outcomes. RESULTS: Scores of (MMAS-8items) ranging from 0 to 8 shows that approximately one-half the participants were (n=66) 52.3% non-adhered or show low adherence while (n=12) 9.5% of patients were adhered (high adherence), the remaining participants (n=48) shows 38% medium adherence. Those non-adhered almost (n=23) 18.2% of them shows low adherence after the first 5 years of diagnosis. About (n=35) 27.7% of none adhered had from 2-3 medications used for RA while those had more than three medications shows only (n=19) 15% low adherence. There were no significant differences between clinical and demographic variables between groups. CONCLUSIONS: The vast majority of RA patients have low to medium adherence score. Advanced age, years of diagnosis and number of medication significantly affect disability score. However, there is no relationship between these factors and pain score.

Speaker
Biography:

Collins Ovenseri Airemwen bagged a Doctor of Pharmacy (PharmD) degree from the University of Benin, Benin-City, Nigeria and a Master of Philosophy degree in Pharmaceutics and Pharmaceutical Technology with a distinction from the same University in 2016. He is currently pursuing his PhD. He has published more than 8 papers. His research is on controlled drug delivery.

Abstract:

This study was carried out to formulate and evaluate gastro-retentive floating matrix tablets (GRFMTs) of Metformin using Grewia mollis gum.

Grewia polysaccharide gum was obtained from the inner stem bark of the edible plant Grewia mollis, Juss, (Fam. Tiliaceae). Granules were prepared by wet granulation technique using the extracted natural gums at varying concentrations (2, 4, 6 and 8% w/w). Sodium bicarbonate (30%) and tartaric acid (5%) were incorporated as the gas generating agents. All granules were evaluated for micromeritic properties. Granules were compressed at an optimized compression pressure of 35 arbitrary unit on the load scale using a single punch tableting machine. Tablets were evaluated for hardness, friability, floating lag time, in vitro buoyancy test and drug release profiles. Compatibility test of the excipients with the API (metformin) was also done using FTIR.

Results revealed that all formulated GRFM granules were free flowing with angle of repose and Carr’s index ≤ 31º and ≤ 14% respectively. The floating lag time for GRFM tablets formulated with Grewia mollis was ≤ 850 s. The in vitro buoyancy test of GRFM tablets formulations using the natural gum alone (i.e. without the incorporation of Eudragit® RL100) were <12 h while those formulations with the incorporation of Eudragit® RL100 were >12 h. There was a significant difference in tablet hardness with increase in binder concentration (p<0.05). The % maximum release (m) and time to attain this (t) for all GRFMTs were ≥87% and ≥4 h respectively. All the formulations fitted well into Higuchi model release kinetics. Release exponent (n) for all the formulations have their exponent values > 0.45, hence their release mechanism was by Non-Fickian diffusion.

GRFM tablets of metformin have been developed for the first time using Grewia mollis gum which can sustain drug formulation for up to 10 h and improve the bioavailability of drugs with narrow absorption window in the upper part of the GIT. Batch GM5 showed a better sustained release profile which can be taken as the optimized formulation.

Biography:

TBA

Abstract:

A specific stability indicating high-performance thin-layer chromatographic method for analysis of Tolterodine Tartrate both as a bulk drug and in formulations was developed and validated. The method employed HPTLC aluminum plates precoated with silica gel GF254 (aluminium sheet) as the stationary phase. The optimized mobile phase system consisted of Ethyl acetate: Methanol: TEA (5:5:0.2 v/v/v) which gave compact spots for Tolterodine Tartrate at 𝑅𝑓 of 0.65. Tolterodine Tartrate was subjected to forced degradation studies in order to check the specificity of the method. Analysis of the drug was carried out at 280 nm. The calibration plots showed linear relationship in the concentration range of 800 – 1200 ng per band. Moreover, linearity was also confirmed by verification of homoscedasticity of variance. According to validation studies, the developed method was repeatable and specific as revealed by % RSD less than 2 and hence can be used for routine analysis of pharmaceutical formulation. The % recovery was found to be 99.23% to 101.00%. Stress studies were conducted on the drug substance and product under the ICH prescribed stress condition viz. hydrolysis, oxidation, photolysis and thermal stress. The drugs showed sufficient decomposition under acidic and alkaline hydrolysis and oxidation. The forced degradation study data represented that the degradation pattern for Tolterodine Tartrate was in Sunlight > UV light > Acid > H2O2 > Base. The developed Stability indicating HPTLC method was found to be sensitive, precise, accurate, economical and reproducible for analysis of pharmaceutical formulation containing Tolterodine Tartrate. Statistical analysis proves that this method can be successfully employed for quantitative analysis of Tolterodine Tartrate in pharmaceutical dosage form.

 

 

Biography:

TBA

Abstract:

Introduction:

Antimicrobial resistance(particularly antibiotic resistance) is spreading now, and there are few prospects for the development of new classes of antibiotics in the short term. However, there is today considerable awareness of the need for and political support for action to combat antimicrobial resistance. Antimicrobials are being used and misused by patients and healthcare providers. Monitoring antimicrobial prescription and consumption behavior provides insights and tools needed to inform therapy decisions, to assess the public health consequences of antimicrobial misuse and to evaluate the impact resistance containment interventions. All reports from WHO tell us about post antibiotics era that will be start if we don’t work quickly on antibiotics resistance by all efforts and due to situations of my country in Libya now need a lot of studies to decrease corruption in budgets put for health sector.

Experimental methods:

Study made by pilot method and we depend on data collected from dispensing papers of medical supply ward in Al Wahda hospital. 

*medical statistics office of Al Wahda hospital

*Al Wahda hospital laboratory

*data collected for 3months and on 477 in- patients of wahda hospital.

Results and discussion:

After collecting data from dispensing paper that is based on treatment chart, we covered 477 patients for 3months by 2169 ceftri-702 gent-1360 aug-547 cefot-23amik. And we noticed that the percentage of higher antibiotics use was ceftriaxone equal to 45.18 % of totality and use of broad antibiotics rather than narrow  antibiotics by 84.9% and all principles of clinical pharmacology direct to use narrow firstly plus first line antibiotics  therapy as shown in figure 1,2 respectively. And the percentage of patients those received antibiotics that is available in hospital from all patients  was 25.3% . we found that the most higher antibiotic sensitive to bacteria was CIPRO and others appear as shown in table below where Ceftriaxone in lower rank by 2.3% as shown in figure no:3 and we found percentage of cultures done to inpatient was 28.09% to all patients' take antibiotics and others take its blindly and we noticed that the higher bacteria strain diagnosed was staph .c. aur and we found that 70 culture tests from 134 shown no bacterial growth which shows mistake in medical  requests. As shown in fig:no 4, we found the higher ward using antibiotics from all wards is FMW and this ward less one  request to culture by 2 requests along study time.

antibs

ceftr

aug

gent

cefot

amik

Totality%

45.18

28.33

14.62

11.39

0.48

 

Figure 1

 

Antibiotic

Broad

Narrow

% Total

84.9 %

15.1 %


Figure 2

 

38.71%

Staph .c.aur

20.97%

E.coli

12.9%

Stap.c.saprophytic

11.29%

Klebsila pnumonia

4.84%

Staph.MRSA

4.84%

Strepto .c. BHSC

1.61%

Staph .epid.

1.61%

Proteus (ESPL)

1.61%

proteus

1.61%

Pseduo.aerg

 

Figure 4

 

Conclusion:

1- Dispensing antibiotics depending on treatment chart decrease wasting in hospital budget.

2- Decision of antibiotics use not comply enough with cultures results of our lab.

3- Staph and Kleb, E.coli much more present in(gyne –pediatric) wards in our hospital.

4- No antibiotic should be used recklessly. However difficult it appears to be to select for resistance in vitro. On the other hand, the attitude that 'All new antibiotics should be locked away' risks stifling innovation whilst denying life-saving treatment debate on their use of new anti-gram-positive agents are sure to intensify  and it is vital that they take place on a basis of science not knee-jerk restrictions or over-zealous marketing .

 

Biography:

Abstract:

Inhaled-medication delivered during mechanical-ventilation is affected by type of aerosol-generator and humidity-condition. Despite many in-vitro studies related to aerosol-delivery to mechanically-ventilated patients, little has been reported on clinical effects of these variables.The aim of this study was to determine effect of humidification and type of aerosolgenerator on clinical-status of mechanically-ventilated asthmatics.72 (36-females) asthmatic-subjects receiving invasive-mechanical-ventilation were enrolled and assigned randomly to 6-treatment groups of 12 (6-females) subjects each received, as possible, all inhaled-medication using their assigned aerosol-generator and humidity-condition during delivery. Aerosol-generators were placed immediately after humidifier within inspiratory-limb of mechanical-ventilation-circuit. First-group used vibrating-mesh-nebulizer (Aerogen-Solo; VM) with-humidification; Second used VM without-humidification; Third used metered-dose-inhaler with AeroChamber-Vent (MDI-AV) with-humidification; Forth used MDI-AV withouthumidification; Fifth used Oxycare-jet-nebulizer (JN) with-humidification; Sixth used JN without-humidification. Measured parameters included clinical-parameters reflected asthma-severity (CP) and end-point-parameters e.g. length-of-stay in the intensive-care-unit (ICU-days) and mechanical-ventilation-days (MV-days).
There was no significant difference between studied subjects in the 6-groups in baseline of CP VM resulted in trend to shorter ICU-days (~1.42days) compared to MDI-AV (p=0.39) and relatively but not significantly shorter ICU-days (~0.75days) compared JN. Aerosol delivery with or without-humidification did not have any significant effect on any of parameters studied with very light insignificant tendency of delivery at humidcondition to decrease MV-days and ICU-days. No significant effect was found of changing humidity during aerosol-delivery to ventilated-patient. VM to deliver aerosol in ventilated-patient resulted in trend to decreased ICU-days compared to JN and MDI-AV. However, we recommend increasing the number of patients studied to corroborate this finding.

 

Biography:

Abstract:

Purpose: Data regarding the use of Ciprofloxacin in children with non-resolving pneumonia are scarce. The present study aims to evaluate the effect of Ciprofloxacin therapy in pediatric patients with non-resolving pneumonia.
Methods: Over the past year, 2012, all pediatric patients with nonresolving pneumonia who received ciprofloxacin treatment in the pulmonary unit of Al-Rantisy specialized pediatric hospital in Gaza, Palestine were included in this retrospective study. Ciprofloxacin was given for all patients in a dose of 20 mg/kg/day divided into two doses.  Patient demographic data, clinical symptoms recorded, sputum culture findings and ciprofloxacin therapeutic outcome were gathered.  Data were analyzed using computer software SPSS version 11.                                      
 
Results: The study included 57 patients with non-resolving pneumonia, 36 males and  21 females with mean age of 3.4 years, ranged from 2 month to 8 years. Fever (73.7%) and cough (89.5%) were the most common symptoms. Positive culture was obtained in 42 (73.6%) patients while 15 (26.4%) showed negative results. The most common organism isolated in the positive cultures was Pseudomonas aeruginosa 26 (62.0%). Among the study sample, 23 (40.4%) patients received ciprofloxacin as empirical therapy and 34 (59.6%) received this drug depending on culture sensitivity results. There was a significant decrease in body temperature levels (P < 0.001) at day 1, 2 and 3 of ciprofloxacin treatment. Overall, ciprofloxacin was effective in the treatment of 53 (93.0%) patients of the present study. Only 4(7%) cases showed resistant to this therapy. The mean length of hospital stay was 7.5 days.  No side effects were reported during the course of this study.
 
Conclusion: Data of the present study suggest that Ciprofloxacin is effective and safe, including as initial monotherapy, for the treatment of pediatric patients with non-resolving pneumonia.
 

Speaker
Biography:

Dr. Krishna Murti has completed  PhD in Pharmaceutical Sciences and has more than 15 years of Experience in academic as well as industry both national and international.His area of interest is diabetes ,cancer and wound healing .Presently ,He is working as Faculty in Department of Pharmacy Practice in NIPER ,Hajipur, institute of National Importance ,established by Government of India. He has published more than 80 papers in reputed journals and has been serving as an editorial board member of reputed journals. He is member of several Pharmaceutical bodies. 

Abstract:

Objectives: Comparative effect of fixed dose combination of Telmisartan+Amlodipine versus Telmisartan and Amlodipine alone on Brain Natriuretic Peptide (BNP), Cystatin - C and blood pressure in essential hypertensive patients.

Methods: A total of 90 patients, fulfilling inclusion and exclusion criteria were enrolled in the study after obtaining informed consent. Patients were randomized into three treatment groups i.e. Telmisartan 40 mg (Group A), Amlodipine 5 mg (Group B)  and low fixed dose combination of Telmisartan 40 mg +Amlodipine 5 mg (Group C) once daily for three  months. The systolic BP, Diastolic BP, BNP, Cystatin C were recorded at the start of the study and end of the study.              

Results: In the present study, significant reduction of mean systolic blood pressure (SBP) and mean diastolic blood pressure (DBP), BNP & Cystatin - C was seen in low fixed dose combination of Amlodipine 5 mg and Telmisartan 40 mg (Group C) compared to Telmisartan 40 mg and Amlodipine 5 mg mono-therapy. Some of adverse drug reactions (ADRs) were reported in Amlodipine mono-therapy group, like ankle oedema, headache, constipation and fatigue.

Discussion and Conclusion: Low fixed dose combination therapy appears to be a better therapeutic approach in relation of BP, BNP and Cystatin-C control than mono-therapy for primary hypertensive patients.

Speaker
Biography:

Prof. M Al-Arifi. Has graduated with Bsc in pharmacy from College of Pharmacy, King Saud University, 1986, and finished his PhD, in clinical pharmacy, from School of pharmacy, Queens' University of Belfast, 1993, since then and up till now in the clinical pharmacy department, college of pharmacy King Saud University. Has engaged in teaching and supervising graduate and undergraduate students and published more than fifty articles for the last twenty years.

 

Abstract:

The study was conducted during the period from May 2006 to September 2006 in Riyadh city. The survey composed of the demographic characteristics of the respondents, asked 6 Likert type questions about the attitudes of the pharmacists toward mental illness,   providing pharmaceutical care to mentally ill patients, the barriers of the provision the service and differentiated between different types of mental illness and compares them with cardiovascular medications.  Although pharmacists have generally positive attitudes toward both mental illness and providing pharmaceutical care to mentally ill patients, they felt uncomfortable counseling or follow-up monitoring patients for adverse drug-related problems when consider distinguishing between different types of mental illness.

Speaker
Biography:

Fadhila Helnisa has completed her bachelor degree from Faculty of Pharmacy on 2014, Andalas University (Indonesia) and has successfully fulfilled all the academic requirements of Indonesian Pharmacist Profession on 2015. Now, she is studying at Master of Toxicology, University of Birmingham.

Abstract:

A study on clinical pharmacokinetics aspect of drugs in patients with hypertension at the Internal Medicine Department of Hospital Padang Panjang (Indonesia) has been conducted. The aims of the research was to determine the accuracy of antihypertensive medications to achieve targeted blood pressure and to assess the dosage regimen based on liver and/or kidney functions, also drug interactions. The study was performed from December 2013 to February 2014. This is observational prospective study with 49 patients who met the inclusion and exclusion criteria. Data was analyzed descriptively. Results showed that 60.42% antihypertensive medications were effective but 39.58% not effective to reach the targeted blood pressure. There were 3 cases in appropriate dose regimen covering 1 case digoxin, 1 case furosemid and 1 case captopril. From the cases, doses exceed individual dose included digoxin and captopril.  There were 14 cases of pharmacokinetic interactions and 2 cases of pharmacodynamic interactions. Interaction between amlodipine and diltiazem (7 patients, 14.58%) influenced the blood pressure control in patient. These are pharmacokinetic interaction because diltiazem decreases metabolism of amlodipine by inhibiting enzyme CYP 3A3/4.

Speaker
Biography:

Alamelu AL, a 20 year old research enthusiast is doing her 3rd year M.B.B.S in Govt. Kilpauk medical college and hospital. Being a budding researcher, she loves to gain knowledge in the field of research by exploring various conferences. She has published a paper in an indexed journal and waiting to contribute to the field of research in future.

Abstract:

BACKGROUND: Stroke is one of the most devastating neurological conditions. Diabetes mellitus is a well-established independent risk factor for stroke. Metformin in addition to its anti-hyperglycaemic effects provides additional cardioprotective effects due to its action on lipid metabolism, endothelial function and platelet activity. Better cerebrovascular outcomes are seen with Metformin due to the fact that it reduces the risk of thrombosis through its effect on fibrinolysis by lowering PAI-1 concentration along with Metformin induced increase in insulin sensitivity. Thus Metformin could be developed into a disease modifying drug to treat stroke. But the association between the duration of Metformin therapy and the severity of stroke has not yet been assessed so far. This study aims at assessing the impact of Metformin and its duration of use on the severity of ischemic stroke in patients with type 2 DM.

OBJECTIVES: To measure the severity of stroke using NIHSS and mRS score and to correlate the severity of stroke with the duration of  Metformin therapy.

METHODS: This is a comparative cross sectional study comprising 60 stroke patients with type 2 DM, without severe renal impairment (serum creatinine < 1.7 mg/dl). Severity of stroke was assessed using National Institute of Health Stroke Scale(NIHSS) and modified Rankin Scale(mRS). The correlation between the stroke severity and metformin use was expressed as correlation coefficient. T-test was used for testing significance between proportions. p < 0.05 was considered as statistically significant.

RESULTS: The mRS score was statistically significant indicating that metformin therapy was associated with decreased severity of stroke showing improvements in functional outcomes (p = 0.017, CI – 95%). However the NIHSS score was not statistically significant (p = 0.114, CI – 95%) and no significant correlation was found between the duration of metformin use and severity of stroke.

CONCLUSION: Metformin therapy in patients with type 2 diabetes mellitus improves functional outcomes of stroke. However in this study, the correlation between the duration of metformin use and the severity of stroke was statistically not significant. The smaller sample size could have limited the statistical interpretation of data. A proper documentation and recording of treatment history of the patients with a larger population size could increase the statistical significance of the study. 

Biography:

Mr. Kaselekela Ponshano completed his advanced diploma in Pharmacy at the age of 27 years from Evelyn Hone College, Zambia and advanced studies in the rational management of medicines from Swiss Tropical Institute, Switzerland. He is the coordinator for pharmacovigilance in the northern region of Zambia. He has published more than 2 papers in reputed journals and has served as the secretary for the Copperbelt University Senior Administrative Staff association (CUSASA). He is the current senior Pharmacy technologist at the Copperbelt University.

Abstract:

Hypertension is described as the persistent increase in blood pressure (BP) above 120/80mmg. With the introduction of newer medicines such as TELMA-H (Telmisartan + hydrochlorothiazide) as well as Amlodipine, many patients used to take other antihypertensive drugs for the management of hypertension which proved to be not bearing positive results to some patients. TELMA-H plus Amlodipine drug was suggested to be introduced to some of the hypertensive patients whose responses to other antihypertensive were not good. A study was done to assess its effectiveness at the Copperbelt University health facility.

A total of 35 male and female clients with unstable BP as well as those not responding well on other antihypertensive drugs were enrolled on the study. The patient’s drug regiments were changed upon their review dates. A register was then opened for all the clients enrolled. The information captured on the register included names of Clients, their current BP, their previous drug regiments and the dates the therapy changed. The treatment were administered once daily for 2 months. A follow- up was made to all patients weekly starting from 1 to 8. Every week there BP were monitored and measured.

Reduced BP was observed to the desired levels. The systolic and diastolic blood pressure reduction were identified in all the clients than to those whom we did not change the therapy. The reduction in BP improved the quality life. treatment of hypertension using TELMA-H plus Amlodipine was proved to be effective in the management of hypertension.

Biography:

Idin Alikhani, 3rd year pharmacy student of  Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract:

Introduction and Background: The impacts of self-medication on the health care costs and patients safety are very significant. Therefore, realizing drugs that is being requested more frequent by people from pharmacies can help finding a reasonable and rational solution to this problem. All around the world, it is evaluated that half of all medicines are prescribed, dispensed or sold inappropriately, and half of all patients do not take their drugs properly. Inappropriate use of drugs is costly and extremely detrimental for both individual and society.

Methods: In this descriptive cross-sectional study, 100 pharmacies (More than 80% of established pharmacies in Kermanshah) filled a 10-item researcher made questionnaire. Data were analyzed using analytic statistical programs.

Results: Results showed that the following drugs had most frequency in patients’ requests: Cap Amoxicillin 500 mg (85.7%), Cap Gelofen® 400 mg (84.4%), Tab Acetaminophen codeine (76.6%), Tab Adult cold (75.3%), Tab Ranitidine (67.5%), Amp Dexamethasone (61.0%), Syr Diphenhydramine compound (53.2%), Vial penicillin 6.3.3 (44.1%), Tab Alprazolam 1 mg (36.3%), cap Novafen® (26.5%)

Discussion and Conclusion: The most important reason of self-medication could be due to 1- Self-awareness assumption about medical and pharmaceutical issues 2- Consumption of mentioned drugs in non-serious illnesses such as common cold, headache, gastrointestinal diseases and sleep disorders 3- Frequent suffering disorders which lead to take medicine, 4- Physician’s crowded office 5- High cost of medical care services, low income and social poverty.

 

Biography:

Abstract:

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this study. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conduct.