Amna Beshir Medani
Nile College of Pharmacy, Sudan
Title: Toxic effects of poly DADMAC introduced to nubian goats in drinking water
Biography
Biography: Amna Beshir Medani
Abstract
The effects of oral doses of polyDADMAC were daily examined on Nubian goats at two different dose-rates, namely 0.5 mg/kg/day and 2.5 mg/kg/day to group (2) and (3) goats respectively compared to untreated Nile water given to a group (1) of control goats under experimental conditions. Death occurred to variable levels. In polyDADMAC dosed animals clinical signs included dullness, loss of weight, loss of appetite, diarrhea, difficulty in respiration, and recumbence. Postmortem changes included haemorrhagic and congested lungs, congested livers, inflamed intestines in addition to bloated rumens and their kidneys showed fatty changes Oral dosing with polyDADMAC caused lung emphysema ,lymphocyte infiltration and edema. Intestines showed congestion and sloughing of intestinal epithelium, their livers manifested generalized fatty change and lymphocyte infiltration and spleens suffered from haemosiderosis, while the control goats showed normal clinical , postmorteum and histopathological picture. The serum concentrations of GPT, LDH , CK and GOT showed variable changes (P<0.01-P<0.001). Serum metabolites significantly increased (P<0.01) –P<0.01) in urea and creatinine values compared to the control group . Deviated values of electrolytes in serum (P<0.01-P<0.001) from the control values namely, magnesium, iron, sodium, potassium, calcium and phosphrus. Other hematological disorders were manifested mostly by the group of goats received the highest dose. Hepatic and renal dysfunctions, as a sequel to treatment with the under-test polymer, were observed forming a co-related picture which expresses its toxic and sometimes lethal effects.
