12^th Annual Pharma Middle East Congress Sep 25-26, 2017 Dubai, UAE

Biography:

He is working as a professor at the Amapá Federal University, Amapá, Brazil and also as a professor  in the course of Pharmaceutical Sciences and Medicine, Academician of the Brazilian Academy of Pharmacy. He is also ex-rector of the Federal University of Amapá elected for the periods 2006-2010 and 2010-2014; member of the Commission of the Brazilian Pharmacopoeia – ANVISA, Brazil; coordinator of policy support policy of the Brazilian Pharmacopoeia Technical Committee on Medicinal Plants and Herbal – ANVISA, Brazil; member of the Technical Chamber of Herbal Medicines,  ANVISA, Brazil.    

Abstract:

Diabetes mellitus (DM) is a syndrome that reaches more than 382 million people worldwide, it interferes with the metabolism of carbohydrates causing chronic hyperglycemia and generating several complications. Faced with this health problem, the objective of this study was to evaluate the effect of the Copaifera duckei Dwyer oleoresin (OR) on streptozotocin-induced (STZ) diabetic rats. This study was based on the induction of DM by STZ (55 mg/kg i.p) in Wistar rats and treated with doses of OR (250 and 500 mg/kg, v.o). Subsequently, the clinical, biochemical and histopathological of the pancreas parameters were evaluated. Gas chromatographic analysis indicated that β-bisabolene (22.29%), β-caryophyllene (21.25%) and α-farnesene (15.58%) sesquiterpenes were the major components of the OR. In STZ-induced DM, it was possible to observe that the OR treatment had a significant effect (p < 0.001) on the clinical parameters (improving positively). Attenuated the urea, creatinine, and transaminases (AST and ALT) alterations (p < 0,001) observed in animals with DM, as well as, significantly reduced (p < 0.001) values of total cholesterol, triglycerides, and glucose. In the histopathological analyses of the pancreas, it was observed that the OR was able to restore β-cells and increase the quantity and diameter of the Langerhans islets significantly (p < 0.05) when compared to the diabetic group. The treatment with Copaifera duckei Dwyer OR (Copaíba), employed under the conditions of this study, presented antidiabetic activity and can improve the complications found in this syndrome. Possibly the agents responsible for the OR effect are the majority sesquiterpenes.

Biography:

Manal Mohammed is currently pursuing her PhD in Pharmaceutical Chemistry at JSS University, Mysuru, India. Her PhD work focuses on the design and synthesis of novel compounds as histone deacetylase (HDAC) inhibitors for cancer therapy. Her research interests include molecular modeling and in silico design of novel molecules using computational tools. Her research is supported by Department of Science and Technology (DST), Government of India under DST Women Scientist scheme.

Abstract:

Epigenetic regulation of gene expression is explicitly controlled via chromatin remodeling, which in turn is controlled through post-translational modifications (PTM) of histone tails. The known PTMs include acetylation, methylation, phosphorylation, sumoylation, and ubiquitylation. In neoplasms, the mechanism of histone acetylation gets imbalanced through the overexpression of histone deacetylase (HDAC) and/or inactivation of histone acetyl transferase (HAT). Moreover, it extends to a plethora of effects including aberrant gene expression, oncogene activation, tumor suppressor gene inactivation and tumor progression. HDAC inhibitors regulate the gene expression and display anticancer potential. In the present study, a pharmacoinformatic approach was applied to develop a pharmacophore model based on a data set of 42 N-(2-aminophenyl)benzamide analogues reported for HDAC inhibitory profile. The generated model comprised of six chemical points, namely two hydrogen bond donors, two hydrogen bond acceptors and two aromatic rings. The statistically validated model (R2, SD, RCV2, etc) was further employed as a basis to design a library of 138 leads, which was checked for matching fitness against the model. The final hits were selected for chemical synthesis depending on binding interaction(s) after molecular docking, binding free energies and in silico ADME properties. These synthesized hits, containing oxadiazole and thiadiazole heterocycles, were investigated for their in vitro HDAC8 inhibitory and antitumour activity. Among all the compounds, the hydroxamic acid analogue containing p-tolyl substituted thiadiazole displayed better HDAC8 inhibitory potential and significant anticancer activity in comparison to FDA approved HDAC inhibitor, SAHA. These results warrant further investigations to substantiate the compound as a promising drug for treatment of cancer.

Biography:

Dr. R. Suresh Kumar has completed his Ph.D. from Jagadguru Shri Shivaraathreeshwara University Mysuru (JSS University, Mysuru) and he is the coordinator for department of Pharmaceutics in JSS College of Pharmacy, Ootacamund. He has filed 3 Indian patents for his research works. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of reputed journals.

Abstract:

Hemorrhoids are one of the most common ailments where the lowest part of rectum and anus veins are swollen. It is estimated that about 75% of people will have hemorrhoids at some point in their lives. Modern therapies for haemorrhoids include various nonsurgical and surgical options, with a trend towards outpatient procedures and day case surgery. In the present study, we hypothesized that the combination of topical nifedipine to lidocaine loaded nanoemulgel would improve pain control by causing a relaxation of the smooth muscle of the internal anal sphincter where it relieves the symptoms of pain by the effect of analgesic action due to Lignocaine and wound healing by Nifedipine. Initially nanoemulsion was prepared optimized by pseudo tertiary phase diagram. The optimized formulatiom was incorporated to gel base to form nanoemulgel. The formulated Nanoemulgel was smooth, shiny and homogenous with pH of 5.9, viscosity of 3541 cps, spreadability of 40 gm.cm/sec, extrudability of 9 gm/cm² and bioadhesion of 4 kg/cm². Drug content of optimized formulation was found to be 98.17% (Nifedipine) and 97.04% (Lignocaine HCl). In vitro study was performed and the nano emulgel showed a cumulative drug release of 41.12% (Nifedipine) and 45.41% (Lignocaine HCl) at 360 min. The Nano emulgel was found to be stable upon storage for 3 months, no major change was observed in their physical appearance, pH, rheological properties with pharmaceutically acceptable and more economic with improved topical formulations for the treatment of anal fissure for better life of the effected patients.

Biography:

Dr. R. Suresh Kumar has completed his Ph.D. from Jagadguru Shri Shivaraathreeshwara University Mysuru (JSS University, Mysuru) and he is the coordinator for department of Pharmaceutics in JSS College of Pharmacy, Ootacamund. He has filed 3 Indian patents for his research works. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of reputed journals.

Abstract:

Hemorrhoids are one of the most common ailments where the lowest part of rectum and anus veins are swollen. It is estimated that about 75% of people will have hemorrhoids at some point in their lives. Modern therapies for haemorrhoids include various nonsurgical and surgical options, with a trend towards outpatient procedures and day case surgery. In the present study, we hypothesized that the combination of topical nifedipine to lidocaine loaded nanoemulgel would improve pain control by causing a relaxation of the smooth muscle of the internal anal sphincter where it relieves the symptoms of pain by the effect of analgesic action due to Lignocaine and wound healing by Nifedipine. Initially nanoemulsion was prepared optimized by pseudo tertiary phase diagram. The optimized formulatiom was incorporated to gel base to form nanoemulgel. The formulated Nanoemulgel was smooth, shiny and homogenous with pH of 5.9, viscosity of 3541 cps, spreadability of 40 gm.cm/sec, extrudability of 9 gm/cm² and bioadhesion of 4 kg/cm². Drug content of optimized formulation was found to be 98.17% (Nifedipine) and 97.04% (Lignocaine HCl). In vitro study was performed and the nano emulgel showed a cumulative drug release of 41.12% (Nifedipine) and 45.41% (Lignocaine HCl) at 360 min. The Nano emulgel was found to be stable upon storage for 3 months, no major change was observed in their physical appearance, pH, rheological properties with pharmaceutically acceptable and more economic with improved topical formulations for the treatment of anal fissure for better life of the effected patients.

Biography:

Dr. GNK Ganesh has completed his PhD at the age of 38 years from jagadguru sri shivarathreeshwara university, Mysuru. Presently he is working as a professor in  JSS College of Pharmacy, Ooty. He has published more than 30 papers in reputed jounals and has serving as an editorial board member of 3 reputed journal .He has presented many papers in both national and international conferences. He is having more than 15 years experiance in both academic and research

Abstract:

Nano emulsions are the novel carriers which offer major enhancements in therapeutics through site specificity, their capacity to escape from multi-drug resistance and to reduce side effects due to its self-assembled nature that is inherently receptive to its direct environment and the flexibility of the components which can be combined to result in structures with multiple responsive functionalities. The aim of the study was to prepare nano emulsion gel containing Imiquimod by spontaneous emulsification method by using Oleic acid as an oil, Labrasol as a surfactant and PEG-600 as a co-surfactant which found to be compatible by FT-IR. The optimized formulation after thermodynamic studies is subjected for various evaluation. The particle/globule size of optimized formulation was found to be 127 nm with -29 mV zeta potential. The TEM analysis reveals that droplets in the nanoemulsion appear dark and the droplet size was in agreement with the results obtained from droplet size analysis using zetasizer. In-vitro release study using franz-diffusion cells resulted in the cumulative release from nanoemulgel and marketed cream at the end of 24 hrs were 65.12 ± 1.23 and 43.41 ±1.21 respectively and the flux calculation shows the linear drug release of the formulation indicating a zero-order kinetics rather than marketed cream. Percentage haemolysis was found to be less than 5% for formulation and marketed cream. In-vitro cytotoxicity study using HaCat cell lines reveals the IC50 values of the plain drug (IQ), prepared nanoemulgel and marketed cream to be 182.2 μg/ml, 260 μg/ml and 200 μg/ml respectively.

Biography:

Prof. Imran Ali is a world recognized academician and researcher. He completed his Ph.D. at the age of 28 years from Indian Institute of Technology Roorkee, Roorkee, India. Prof. Ali is known globally due his great contribution in anti-cancer and chiral drugs development and water treatment. He has published more than 350 papers in reputed journals including papers in Nature and Chemical Reviews of more than 41 impact factors. He has also five books published by Marcel Dekker, Inc., USA; Taylor & Francis, USA; John Wiley & Sons, USA; John Wiley & Sons, UK; Elsevier, The Netherlands. His citation is 12,000 with H index 46. 

Abstract:

Routine allopathic chemotherapy for cancer treatment has several side and toxic effects. Since long time Unani medicine is being used to cure cancer.  More than twenty Unani herbal drugs are being used for the prevention and treatment of cancer. Several mechanisms are likely to account for the observed pharmacological effects. The most important being direct cytotoxicity, apoptosis induction, antioxidation, and immunomodulation. These Unani herbal drugs may help to synergize the anticancer effects, and reduce the side effects of conventional drugs. The different plants used are dillenia indica, Oroxylum indicum, terminalia arjuna etc. The proposed lecture will comprise the-of-art of Unani medicines in cancer treatment. Besides, the mechanism of action and future perspectives will be discussed.

Biography:

Sahar S Abd El-Rahman is currently a Professor of Pathology, Faculty of Veterinary medicine, Cairo University, Egypt. Dr. Sahar is an active Member in Egyptian Veterinary Medical Society of Pathology and Clinical pathology (EVMS) and Egyptian Veterinary Medical Association (EVMA). She has attended several continued education and technical workshops since, 1993. In addition, she has attended a number of workshops on Quality assurance and Development of Faculty Members. She has joined a number of scientific conferences since 2002, in some of them she was a member of the Organizing Committee. Dr. Sahar has shared in the supervision as well as in the arbitration of a number of master and doctoral theses. She has published about 34 scientific papers, 18 of which were published in international journals. She is a reviewer in a number of international journals and a member of the editorial board in other international journals.

Abstract:

Introduction: AflatoxinB1 (AFB1) is well-known as a feed borne-immunosuppressive mycotoxin. Nanotechnology is a powerful new technology for reconstructing nature at the atomic and molecular level. This study was conducted to determine the efficacy of nano-composite magnesium oxide and silicon oxide (MgO-SiO₂) to reduce the toxic effects of AFB1on the immunity of adult male rats for 8 weeks. Experimental design: Animals were divided into a control (Gp1) and three experimental groups (Gps); Gp2 received feed contained 0.5g/kg nano-composite MgO-SiO₂, Gp3 received feed contained 200ppb/kg AFB1. While rats of Gp4 received feed contained 200ppbAFB1/kg and 0.5g/kg the nano-composite. Methods: Cellular and humoral immune responses, as well as histopathological examination and caspase-3 expression in liver, spleen, and GIT were all evaluated. Residual concentration of AFB1was determined in serum, liver and fecal samples. The obtained data were statistically analyzed. Results: AFB1markedly reduced body weight gain and food and water consumption. Both cellular immune response (total and differential leukocytic count, neutrophils’ phagocytic activity, lymphocyte transformation, macrophage activity and serum lysozyme activity) and humoral immune response (serum total protein and its fractions as estimated by SDS- PAGE electrophoresis) were severely reduced by AFB1. Moreover, AFB1induced marked histological alterations and apoptosis in liver, spleen, and GIT. The addition of nano-composite MgO-SiO₂ to feed containing AFB1 could markedly alleviated the deleterious effects of AFB1. Conclusion: These findings suggested that nano-composite MgO-SiO₂ has high affinity to adsorb AFB1and can effectively modulate its toxicity in rats. Impact statement: Nano-composite MgO-SiO₂ may offer a novel approach for the preventive management of aflatoxicosis in animals.

Biography:

Sherin zakaria has completed her PhD at the age of 32 years from Tanta University . She had started her academic work at Damanhour university. She was the head of quality assurance unit and executive director of SDEE project at faculty of pharmacy, Damanhour university. Recentally, she had moved to Kafer elsheikh university. She had  published more than 10  papers in reputed journals and has been serving as an editorial board member of some journal such as Journal of gastroenterology and hepatology research, American journal of pharmacological sciences and  Tumor biology.

Abstract:

Rebamipide is an antiulcer drug that found to be effective in treatment of chemotherapy induced oral mucositis. This study investigates possible role of keratinocyte growth factor (KGF) and interleukin 10 (IL-10) in rebamipide healing activity. Mucositis was induced by single IP injection of 5- fluorouracil (5-FU) (150 mg/kg). A subsets of 5-FU treated rats were treated with rebamipide suspension (30 mg/kg/ two times a day). Mucositis was assessed according to WHO grading system. Malondialdhyde (MDA), superoxide dismutase (SOD), expression of IL-10, myeloperoxidase (MPO) and KGF was also assessed. Oral mucositis incidence was decreased in Rebamipide treated rats compared to 5-FU. Rebamipide induced a significant (p≤ 0.001) decrease in oxidative markers induced by 5-FU. Rebamipide significantly inhibited expression of MPO (p≤ 0.001) as well as upregulated IL-10 (p≤ 0.01) and KGF (p≤ 0.001) compared to 5-FU. In conclusion, Rebamipide ameliorated 5-FU induced oral mucositis. The healing effect of rebamipide may be due to IL-10 and KGF upregulation.

Biography:

Ms. Mansi Paradkar has completed her M.Pharm (Pharmaceutics) at the age of 24 years from Sardar Patel University. She is currently associated with Department of Pharmaceutics and Pharmaceutical Technology of Ramanbhai Patel college of Pharmacy, CHARUSAT University as an Assistant Professor since 5 years. Her accomplishments in the current organization include supervising nine pharmaceutics projects of Master of Pharmacy students in the area of cerebral malaria, colon cancer, fungal infection, rheumatoid arthritis, emesis by formulating various drug delivery systems including application of nanotechnology. Her research publications are in the journal of 'Drug development and Industrial pharmacy' and 'Saudi Pharmaceutical journal'. One of her research work has been filed for Indian patent.

Abstract:

Artemether (ARM) microemulsion (ME) for intranasal delivery was developed using Isopropyl Myristate (IPM) as oil, Cremophor EL as surfactant and propylene carbonate as co-surfactant by water titration method. The optimized batch ME1 was evaluated by globule size, zeta potential, viscosity, TEM and solubilization capacity.  %In vitro Drug release using modified Franz diffusion cell and histopathological studies from ME1 was carried out through sheep nasal mucosa. Comparative in vivo anti-malarial performance of the developed ME1 was evaluated against the ARM solution and marketed oral ARM formulation (Larither®) Plasmodium berghei infected mice as per Peter’s four day protocol. The parameters studied were %parasitemia, activity against time and animal survival period. TEM micrographs indicated that ME1 had a nearly monodispersed spherical shape with size ranging about 30nm. The mean viscosity of about 106.7cP suggested increased residence time and -18.43±0.86 Zeta potential indicated stability. Significant improvement in drug solubility overcome dissolution rate-limited absorption of ARM and this was realized with higher permeation coefficient during ex-vivo drug release studies. Histological examination of formulations did not show any remarkable damage to nasal mucosa. The animals treated with ME1 exhibited highest reduction in the percent parasitemia and 4 fold higher antimalarial activity with reduced mortality rate as compared to all other groups (P < 0.05). This demonstrates the utility of the microemulsion approach in improving the delivery and therapeutic efficacy of ARM through intranasal administration for the treatment of malaria.

Biography:

Grandhi Surendra has completer PhD from Andhra University in pharmaceutical chemistry Department. He has acquired 9 years of reserach experience and published more than 15 National and International journals, he has also presented a paper at a conference in Malyasia.

Abstract:

Objectives: The aim of the present study was to estimate flavonoid and phenolic content, and to evaluate invitro antioxidant activity of an aqueous extract of Alpinia nigra and Allium tuberosum.
Methods: The air dried stem of A. nigra and leaves of A. tuberosum was ground to powder and extracted with water and 95% of ethanol. The extract was screened for phytochemicals, total phenolic content (TPC) and total flavonoid content (TFC) with its potential antioxidant activities using hydrogen peroxide-scavenging assay.
Results: Phytochemical test shows that extract contains variety of phytochemicals among which there is a high level of total phenol and flavonoids. The total phenolic content (TPC) of A. nigra and A. tuberosum was 0.450±0.0740 and 1.663±0.296; respectively. The total flavonoid content (TFC) of A. nigra and A. tuberosum was 0.322±0.077 and 0.978±0.119, respectively. The plants possessed potent antioxidant activity when compared with the reference compound ascorbic acid (vitamin C).
Conclusions: A. nigra and A. tuberosum may be useful for the preparation of neutraceuticals as potent antioxidant to treat various human diseases and their complications.

Biography:

Jagruti Prajapati has completed her M.Pharm from Maharaja Sayaji Rao Unmiversity of Baroda, Vadodara and pursuing Ph.D and working as Assistant Professor at the age of 27 years from Ramanbhai Patel College of Pharmacy, CHARUSAT, Changa. She has published 5 papers in reputed journals and writing two book chapters in reputed publication.

Abstract:

“Agomelatine” is melatonin receptor (MT1 & MT2) agonist and 5HT2c antagonist, widely used for major depressive episode, absolute bioavailability is <5%. The aim of present study is to develop Agomelatine microemulsion for intranasal delivery, to improve bioavailability. Preformulation study (Purity& Compatibility) was established by Melting point, λmax by UV–Visible spectrophotometry, FTIR, XRD, DSC. Solubility study of drug was conducted in various oils, non-ionic surfactants and co-surfactants. Ternary phase diagrams were constructed to evaluate the microemulsion regions for 1:1, 1:2, 1:3, 2:1, 3:1 of Smix (Chemix). A single isotropic region was found in pseudo-ternary phase diagrams. Microemulsion was formulated by water titration method. Smix ratio 1:1 was selected based on ternary phase diagram and conductivity measurement. In preliminary study, the concentration of oil and Smix were optimized on the bases of globule size. Reported dose of drug is successfully loaded in 0.1ml of ME prepared using optimized oil and Smix concentration range. Microemulsion of Agomelatine was optimized by mixture design of experiment. Prepared microemulsion was characterized by globule size (15 nm), viscosity (80 cps), zeta potential (-47mv) and TEM, Confocal Microscopy Study. In vitro drug release study of pure drug and Agomelatine Microemulsion was performed, in which Agomelatine microemulsion shows 100% Cumulative Drug Release which follows higuchi model. In vivo study (Pharmacokinetic and Pharmacodynamic) was also performed. Pharmacodynamic study was done by Forced Swim test. Pharmacokinetic study revealed that Bioavailability of Agomelatine Microemulsion was increased. Stability study of the same was also performed for heating-cooling cycle, freeze-thaw cycle and centrifugation.

Biography:

Mohamed Mahmoud Elseweidy is a professor of  clinical Biochemistry and clinical nutrition since 1991 at Zagazig University, Egypt. He is also a member of Permanent Scientific Committee (supreme Council of universities, EGYPT) for professors and assistant professors positions (Biochemistry). His research interests include diabetic complications and hyperlipidemia, natural antioxidants and their applications in hyperlipidemia and diabetic nephropathy gastritis, role of Helicobacter pylori and natural products as therapeutic agents. He is a member of American Association for clinical chemistry, American Society for clinical Pathology (ASCP), Egyptian Society for clinical chemistry, Egyptian Society for Pharmaceutical Sciences, Clinical Laboratory Scientist (CLS/ chemistry).

Abstract:

Insulin-degrading enzyme (IDE, insulysin) is a rate–limiting enzyme in the insulin degradation process. It is an intracellular 110-kDa thiol zinc-metalloendopeptidase located in the cytosol, peroxisomes, endosomes and cell surface. IDE catalyzes degradation of several small proteins including insulin, amylin and β-amyloid protein. In addition, insulin clearance was expressed as a target in the treatment of type 2 diabetes given the role of hyperinsulinemia in the pathogenesis of insulin resistance. In this study, fourtyadult male Wistar albino rats were used, thirty rats received 20% fructose in drinking water (HFW) for six weeks to induce diabetes. Subsequently, these rats developed significantly higher body weights, dyslipidemia, hyperglycemia and insulin resistance compared to their controls. Significant increase in the levels of serum glucagon, IDE in liver tissue along with an inhibition of insulin receptor phosphorylation were also observed. Concurrent oral administration of vitamin D3 along with HFW resulted in significant decrease of serum glucose, total cholesterol, triacylglycerol and LDL-C levels. Vitamin D alleviated also insulin resistance, where both IDE, glucagon levels showed significant decrease along with activation of insulin receptor phosphorylation. Normal rats, received vitamin D3 only demonstrated non significant changes of the studied biomarkers. We concluded that vitamin D3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received HFW through reduction of IDE and activation of insulin receptor phosphorylation.

Biography:

Rubab Zohra is working as an associate professor (department of chemistry) in Forman Christian College (A Chartered University), Lahore, Pakistan.

Abstract:

It was planned to synthesize dual-responsive hydrogels from N-isopropyl acrylamide (NiPAAm), acrylic acid (AA) and methacrylate (MA). Hydrogels were prepared by free radical copolymerization using ethyl alcohol as a solvent, a redox initiator, benzoylperoxide (BPO) and ethylene glycol dimethacrylate (EGDMA) and diethylene glycol dimethacrylate (DEGDMA) as cross-linkers. The network parameters like polymer mesh size (ξ) (23.78 to 820 Å), molecular weight between the cross-links (M_c) (970-356096 gmol^-1) and crosslink density (q), (0.0928 to 0.00025) were calculated at various pH using the Flory-Rehner Theory. Hydrogels exhibited the non-Fickian diffusion mechanism. FTIR spectral analysis and (TGA/DSC) were carried out to characterize the systems and new LCST was found to be increased. Tramadol HCl was used as the model drug to investigate the drug loading and unloading behavior of these gels. It was concluded that these systems exhibited a sharp change in their media sorption capacity and mesh size of the networks with the change in the pH and temperature of the swelling media, proposing their strong candidature for being used as oral drug delivery systems. The results favored the idea to apply these hydrogels to use as targeted drug delivery systems for the proximal part of the gastro-intestinal tract.

Biography:

Abstract:

Co-amoxiclav for pediatric use comes as oral powder, which has to be reconstituted before administration. Concerns have been raised regarding the appropriateness of environmental conditions. A stability study was carried out on the original brand (Augmentin) suspension which were reconstituted and kept under the standard storage conditions of 2-8ºC and at home conditions (25ºC). Both compounds (amoxicillin and clavulanic acid) were considered stable if they retained 90% of their initial concentrations. From the study, it was found that the home conditions had no significant detrimental effect on the stability of amoxicillin but had a significant on stability of clavulanic acid, throughout the duration of therapy (10 days). However, the standard storage temperature should be adhered stringently to guarantee maximum therapeutic benefit. This revealed that amoxicillin remained stable throughout the duration of therapy but clavulanic acid did not. Physical compatibility was assessed by visual observation for discoloration and precipitation throughout the duration of therapy. The chemical stability of the drug was analyzed by HPLC instrumental method. The various parameters analyzed include description, odor, color, taste, assay, water content, specific gravity, and pH. These parameters were evaluated at zero day, 3rd day, 7th day, 10th day intervals. The results of assay indicate that the samples are within the allowable limits (90-120%) for amoxicillin at recommended conditions and home conditions, but the storage of augmentin suspension at home conditions (25ºC) showed that the clavulanic acid rapidly exposed to degradation directly after reconstitution of all batches after 3 days, the assay test were out the limit, however when stored at refrigerator temperature (2-8ºC), the degradation of clavulanic acid is very low after prolong period (about 10 days). The results of amoxicillin concentration in all tested batches that were stored at 2-8ºC were very similar to the results of assay that were stored at room temperature.

Biography:

Abstract:

Biography:

Abdullatif Ali Azab was born (1960) in Ara, a famous historical location in Wadi Ara. He completed all his degrees in the Hebrew University of Jerusalem (PhD in medicinal chemistry). After a long career (35 years) in chemical education (high schools and colleges), along with chemical industry (chemical hazardous waste treatment, 6 years), he moved to research of medicinal plant, actually returning to his family traditions, where many of his ancestors were traditional healers. Galilee Society, he is starting now his own Eastern-Plants-Company, which will produce plants based cosmetic and food producs. It will also include research (young Arab researchers) and educational (mainly for high school) divisions. In the mean time, his research continues in the Triangle Research & Development Center (TRDC) of Al-Zahrawi Society (http://www.trd-center.org). Azab has scientific collaborations with well known scholars in Israel and seeking more with the international scientific community, especially in the middle eastern region and the Mediterranean countries. Azab has significant skills in organic synthesis, spectroscopy (especially NMR and GCMS) and vast knowledge of his homeland plants. In 2013 while performing his post doctoral research in the radiology (MRI) department of Hadassah Medicla center of the Hebrew University, he was awarded the Teva (drug company) neuroscience award for an outstanding synthesis protocol of a psychoactive compound. 

Abstract:

Plants are by humans used for medicinal purposes since the dawn of humanity. Among these, plants with anti-inflammatory activity are well known to most cultures, especially the Palestinian traditional medicine which is known for its vastness. However, this ethnomedicine used many plants of different genera to treat inflammations. The methods of herbal treatment were documented or passed verbally through generations. Among these plants, there are well known to other cultures such as Malva sylvestris, Micromeria fruticosa and Salvia officinalis. Expectedly, modern, published research approves this traditional knowledge (Benso, B. et al, 2016; Abu Gharbieh, E. et al., 2013 and Baricevic, D. et al, 2001, respectively). But these are aromatic plants, with very pleasant odors, that are expected to have medicinal activies. Carob (Ceratonia siliqua) is a very well known tree for Palestinian culture, and its very impotrant nutritional resource. Its anti-inflammatory capacities were known and used for centuries, especially against mouth and throat inflammations. But strangely and interestingly enough, the anti-inflammatory of this proven activity was studied just in the last few years (Lachkar, N., et al., 2016; Rtibi, R., et al., 2016). Our current research focuses of other plants that are known to Palestinian ethnomedicine for having anti-inflammatory and other medicinal activities. Currently, we have studied three plants and the results indicate that at least one of them has proven anti-inflammatory activity. Our list includes other 16 plants that were reported to us by local Palestinian people as having such activity. These plants have three common properties: 1) Their anti-inflammatoty potential was never studied and published before. 2) The chemical compositions of all of them are either partially or completely unkown. 3) All of them are known to Palestinian ethnomedicine as having medicinal potential. We will present some plants that Palastenian ethnomedicine use to treat inflammations, published, being studied and with future research plants.

Biography:

Abstract:

Mitoxantrone is an anti-neoplastic anthracenedione derivative that inhibits DNA replication and induces single and double strand breaks by intercalating in DNA through hydrogen bonding. Mitoxantrone is used in the treatment of certain types of cancer such as acute myeloid leukemia and is one of the few drugs approved for the treatment of progressive multiple sclerosis (MS).As a Topoisomerase II (TOP2) inhibitors ,mitoxantrone cause DNA damage in normal cells through apoptosis, mitochondrial dysfunction, free radical generation and lipid peroxidation. Erythropoietin (EPO) is an essential glycoprotein that facilitates red blood cell maturation from erythroid progenitors and mediates erythropoiesis. The use of recombinant human EPO (rHu-EPO) dramatically changed management of anemic patients with chronic kidney disease and improved their quality of life. Besides, recent research’s showed that (EPO) was a major component of tissue-protective system. EPO prevents apoptosis, reactive oxygen species generation and lipid peroxidation process. But the long-term or frequent administration of rHu-EPO due to its short half-life and high doses associated with adverse side effects such arterial hypertension, cerebral convulsion/hypertensive encephalopathy; thrombo-embolism,iron deficiency and influenza-like syndrome. One of the major reasons for the growing interest in nano-drug delivery systems is the potential to generate targeted delivery, decreased in doses and triggered release of drugs to specific cells and tissues. Therefor in this study we report first, the production and characterization of nanoparticles using the ionotropic gelation method between the biopolymer chitosan (CS) and tripolyphosphate (TPP) ion with simultaneous encapsulation of the glycoprotein rHu-EPO and subsequently explore the effect of CS-TPP-EPO nanoparticles in mitoxantrone-induced genotoxicity. For this purpose cells were incubated with regular rHu-EPO and rHu-EPO loading (CS-TPP) nanoparticle and mitoxantrone in pre and co-treatment condition. Our results showed that both regular rHu-EPO and rHu-EPO loading chitosan tripolyphosphate nanoparticles reduced the effects of mitoxantrone significantly by reduction of the level of DNA damage measured with the comet assay.

Biography:

Prakash Kinthada is a Professor in Chemistry at Sri Vidyanikethan Engineering college, JNTU University in Ananthapur, A. Rangam Peta, Tirupathi, India.

Abstract:

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc. My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry, especially Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron,  Nickel, Zinc, Cadmium etc.

The main emphasis of my talk would be on different class of ligands, their Schiff’s bases and transition metal complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing binding sites and diverse strategies employed by my group for elucidation of anti-cancer and anti-HIV drug leads to circumvent the problem caused by Cis-Platin. We have synthesized and characterized several phytochemicals from traditional medicinal plants and isolated some phytochemicals and made the corresponding oximes, thiosemicarbazones and substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their transition metal complexes especially with Gold, Platinum, Palladium, Ruthenium, Copper etc. and studied their anticancer activity, nuclease activity etc. and tested their potential as anticancer drugs. The main aim of our extensive/preclinical pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavanoids etc., which have very interesting structural features and properties and hence are excellent candidates as anti-cancer and anti-HIV drugs. The main aim of our research is design, development and synthesis of transition metal complexes/organometallic compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance cancer killing with less toxic effects and would certainly lead to initiation of clinical trials.

Biography:

Khan’s interests include translation of epidemiological information to national, regional and global disease control policy. His work has focused on generating scientific evidence through basic research, facilitate surveillance networks and promote the use of vaccine to control infectious disease by conducting vaccination demonstration project. His research and work has been regularly published in scientific journals since 2004.

Abstract:

Typhoid vaccines have been available as a means of disease control and prevention since 1896; however, their use as a routine tool for disease prevention in endemic settings has been hampered because of: 1) insufficient data on disease burden particularly regarding the lack of health care access in the poorest communities affected by typhoid; 2) limitations of the typhoid vaccine, such as shorter duration of protection, moderate efficacy in young children, and no efficacy for infants; 3) inadequate evidence on potential economic benefits when used at scale; 4) neglect in favor of alternative interventions that require massive infrastructure; 5) no financial support or commitment regarding vaccine delivery cost; 6) ambivalence about whether to invest in water and sanitation hygiene versus the vaccine; and 7) clarity on global policy for country adoption. The World Health Organization (WHO) in 2008 recommended the use of currently licensed typhoid vaccines using a high risk or targeted approach. The epidemiology of disease and the vaccine characteristics make school-based vaccination most feasible in reducing typhoid disease burden in many settings. To assess feasibility of school-based typhoid vaccination, two districts in Kathmandu, Nepal and two towns in Karachi, Pakistan were selected for pilot program.. In total 257,015 dosesof Vi polysaccharide vaccine were given to students in grades 1–10 of participating schools. The vaccination coverage ranged from 39 percent (38,389/99,503) in Gulshan town in Karachi, to 81 percent (62,615/77,341) in in Kathmandu valley. No serious adverse event was reported post vaccination. The coverage increased in the second phase in Pakistan and Nepal. There was an initial concern of vaccine safety. However, as the campaign progressed, parents were more comfortable with vaccinating their children in schools. Supported and conducted by departments of health in Pakistan and Nepal, a school-based typhoid vaccination was found to be safe and feasible.