Todd Siler is an internationally recognized visual artist, author, and innovation consultant. Hernreceived a PhD in Interdisciplinary Studies in Psychology and Art from the Massachusetts Institute of Technology in 1986, becoming the first visual artist to receive this degree at M.I.T. Siler began advocating integrating the arts and sciences in the mid-1970s, and founded The ArtScience Program, which pioneered arts-based learning methods and tools for generating innovations. The World Cultural Council awarded him the 2011 Leonardo daVinci World Award of Arts, recognizing Siler’s practice of applying the ArtScience process to envision solutions to global challenges.rn
Pharmacology, which marks its 19th century origins with the work of synthetic organic chemist Friedrich Wohler, promises a rich future in the evolution of drug discovery, development and medical applications that impact human health and wellness. Understanding the physiological activity and therapeutic effects of chemical compounds on human systems remains a concerted collaborative effort of pharmacologists considering the combined empirical studies by neuropsychologists, neuropharmacologists, toxicologists, microbiologists, clinicians, and many other specialists whose work informs drug design and therapy. This article explores some best practices in the Arts that foster creative inquiry, discovery and innovation, which may help advance knowledge of how drugs interact with the body (pharmacodynamics) and vice versa (pharmacokinetics):from drugs known to affect the actions of enzymes and cell-receptors to biochemical changes in cell/neurons that reveal the body’s response to various medicinal packages. Indeed, there’s a fine art to Pharmaceutical Sciences that can catalyze vital innovations leading to new treatments and means of preventing common illnesses and uncommon diseases. What new theories, tools, techniques and approaches can be used to this end? What new or basic questions need to be raised in Pharmacology that challenges the whole field to continually innovate? The author focuses on Neuropharmacology, which provides practical insights into the unsolved mysteries of how drugs influence the human brain and body it governs: from genes to proteins to networks of neural tissue to affective and cognitive processes to intentional actions and behaviors.
Associate Professor of Biochemistry at the department of Life Sciences of Al-Quds University. Director of the Biochemical laboratory. Educated at Birzeit University, West Bank and The Hebrew University of Jerusalem. Jerusalem. A member of the Medical Screening Society .London, UK.
Malaria is a life threatening parasitic disease which is prevalent mainly in developing countries; it is the main cause of global mortality and morbidity. Development and search of novel and effective anti-malarial agents to overcome chloroquine resistance have become a very important issue. Most anti-malarial drugs target the erythrocytic stage of malaria infection, where hemozoin synthesis takes place and is considered a crucial process for the parasite survival. Throughout last decades, natural products have been a significant source of chemotherapeutics especially against malaria. Inula viscosa, is a shrub that grows around the Mediterranean basin and considered as an important Palestinian traditional medicinal herb. In this research it was found that the Palestinian flora Inula viscosa alcoholic extract has a significant and promising anti-malarial effect in both in vitro and in vivo systems. The crude alcoholic extract of Inula viscosa has the capability to impede the formation of β-hematin in-vitro; with an efficiency of about 93% when compared to the standard chloroquine which gave 94% at comparable concentrations. In vitro studies showed also that this crude extract inhibited the growth of Plasmodium parasites in the red blood cells at a rate of about 96.6%, with an EC50 value of 0.55 ng/mL. Several secondary plant metabolites may be responsible for this anti-malarial activity; the effect also may be most probably due to the presence of high concentrations of nerolidol which has often been found at high concentrations in this plant. Nerolidol shows a stronger inhibition of hypoxanthine incorporation than quinine. Its anti-malarial effect is potentiated by other essential oils. Nerolidol is also found in several Artemisia species and in Cymbopogon citratus (lemongrass) and Virola surinamensis, all plants known for their anti-malarial properties.